Human Papillomavirus (HPV) Transcripts in Malignant Inverted Papilloma are from Integrated HPV DNA

McKay, Shawn P.; Grégoire, Lucie; Lonardo, Fulvio; Reidy, Patrick M.; Mathog, Robert H.; Lancaster, Wayne D.

doi:10.1097/01.mlg.0000168091.50584.b4

Cited by 67 publications

(55 citation statements)

References 13 publications

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“…Nineteen of 20 HPV-positive IPs in our study showed HPV-11, and one showed HPV-6. These data were compared with the results of 22 published studies in which PCR was used for HPV detection [15,22,23,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. As summarized in Table 2, a total of 720 IPs have been analyzed in previous studies, and HPV DNA was detected in 203 (28.1%).…”

Section: Discussionmentioning

confidence: 95%

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In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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Inverted papillomas (IPs) are the most frequent type of sinonasal papillomas. These benign but destructive lesions are known for their high recurrence rate, probably due to incomplete excision. Our aim was to investigate the frequency of human papillomavirus (HPV) infection in patients with IPs and in IPs associated with squamous cell carcinoma (IPsSCC) and to compare it with the frequency of HPV infections in the control group. The influence of HPV infection on the malignant alteration and recurrence rate of IPs was also evaluated. Paraffin-embedded tissue samples from 68 patients with sinonasal IPs and 5 patients with IPsSCC were analyzed in this retrospective study. The control group consisted of 47 patients who had undergone septoplasty or mucotomy of the inferior turbinate. PCR amplification with consensus primer sets was performed to detect alpha-HPVs, and direct sequencing of the PCR products with the same primers was used to determine the HPV genotypes in the samples. We detected HPV DNA in 20 (30.3%) patients with IPs, in 3 (60%) patients with IPsSCC, and in 6 (13%) patients from the control group. The frequency of HPV infection in the study group was statistically significantly higher (p = 0.032) than in the control group. The presence of HPV DNA was not a statistically significant predictor of the recurrence of IPs (p = 0.745) nor was it a statistically significant risk factor for associated SCC (p = 0.32). Since HPV type 11 was the predominant genotype in the IPs, IPsSCC, and in the control cases, we presume that HPV infection may represent incidental colonization rather than being an important etiological factor of IPs.

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Section: Discussionmentioning

confidence: 95%

“…The malignant alteration of IPs has been widely recognized [1,4,8,22,23,[42][43][44][59][60][61][62][63][64][65]. Of all carcinomas associated with IPs, 61% are synchronous and 39%, metachronous [66].…”

Section: Discussionmentioning

confidence: 99%

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

et al. 2011

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“…Recent studies using in situ hybridization detected HPV 6 and 11 in 42% of cases. In particular, IP associated with severe dysplasia or carcinoma and HPV 6 or 11 was present in 57 and 67% of tumors (42 (45). In particular, it was detected in two of three patients in which IP was associated with sinonasal SCC.…”

Section: Histopathologymentioning

confidence: 92%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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“…SCC arising ex-inverted papillomas also reveal HPV RNA transcription, and evidence of viral integration [66]. [97].…”

Section: Hpv In Other Laryngeal Lesionsmentioning

confidence: 99%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

223

218

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Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on ''treatment deintensification'' for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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Human Papillomavirus (HPV) Transcripts in Malignant Inverted Papilloma are from Integrated HPV DNA

Cited by 67 publications

References 13 publications

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

In Inverted Papillomas HPV more likely represents incidental colonization than an etiological factor

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

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