Human papillomavirus (HPV)-associated trilateral squamous neoplasia in immunocompetent individual

Iovieno, Alfonso; Piana, Simonetta; Chiesi, Laura; Fodero, Cristina; Fontana, Luigi

doi:10.1007/s10792-017-0573-8

Cited by 2 publications

(6 citation statements)

References 16 publications

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“…Synchronous presentation of bOSSN has been more commonly reported in literature than metachronous lesions (Table 1). 11–24 However, a near-equal distribution was seen in the present series with 56% showing synchronous presentation and 44% showing metachronous presentation. Of these, in 25% ( n = 7) of eyes with synchronous presentation and 41% ( n = 9) of eyes with metachronous presentation, there were no presenting symptoms.…”

Section: Discussionmentioning

confidence: 48%

“…In addition to XP and HIV, 7–9 various other risk factors have been identified for bOSSN. 10–24 Conjunctival xerosis, a manifestation of altered Vitamin A and retinoic acid metabolism affecting both eyes, has been implicated in etiopathogenesis of OSSN. 28 Ramasubramanian et al 29 attributed occurrence of corneal OSSN after keratoplasty to local immunosuppression due to chronic use of topical steroids.…”

Section: Discussionmentioning

confidence: 99%

“…4–9 Isolated case reports on bOSSN demonstrate association with HIV, XP, HPV infection, hereditary factors, atopic conjunctivitis, chronic wood dust exposure, ocular cicatricial pemphigoid, neurodermatitis and epidermo-dysplasia verruciformis, and other systemic cancers (Table 1). 10–24 However, literature pertaining to clinical presentation and outcomes of bOSSN is sparse. 10–24 This retrospective series of 25 patients aims to determine the incidence and prevalence, describe the risk factors, clinical presentation, management, and outcomes of bOSSN.…”

Section: Introductionmentioning

confidence: 99%

“…10–24 However, literature pertaining to clinical presentation and outcomes of bOSSN is sparse. 10–24 This retrospective series of 25 patients aims to determine the incidence and prevalence, describe the risk factors, clinical presentation, management, and outcomes of bOSSN.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

Vempuluru

Pattnaik

Ghose

et al. 2021

European Journal of Ophthalmology

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Purpose: To describe the risk factors, clinical presentation, management, and outcomes of patients with bilateral ocular surface squamous neoplasia (OSSN). Methods: Retrospective case series. Results: Of the 25 patients with bilateral OSSN, the mean age at diagnosis of OSSN was 31 years (median, 24 years; range, 2–60 years). Risk factors for bilateral OSSN included xeroderma pigmentosum ( n = 15, 60%), human immunodeficiency virus infection ( n = 3, 12%), conjunctival xerosis ( n = 1, 4%), and topical steroid use ( n = 1, 4%). There were no identifiable ocular or systemic risk factors in 7 (28%) patients. Presentation was synchronous in 14 (56%) and metachronous in 11 (44%) patients. Tumor morphology was bilaterally similar in 12 (48%) patients. Histopathological examination ( n = 36) revealed conjunctival intraepithelial neoplasia (CIN) grade 1 in 4 (8%); grade 2 in 7 (14%); carcinoma in situ in 5 (10%), and invasive carcinoma in 20 (40%). Primary management of OSSN ( n = 49) included excisional biopsy ( n = 31, 62%), topical immunotherapy (IFN α2B) ( n = 11; 22%), topical Mitomycin C (MMC) ( n = 3, 6%), enucleation ( n = 1, 2%), orbital exenteration ( n = 2, 4%), and plaque brachytherapy (PBT) ( n = 1, 2%). One patient was lost to follow-up after detection of tumor in the second eye. Recurrent tumors were noted in 16 (32%) eyes and binocular globe salvage was achieved in 16 (64%) patients at a mean follow up of 41 months (median 30 months; range, 1–164 months). Conclusion: OSSN occurrence can be synchronous or metachronous. Meticulous examination of the fellow eye is important for an early diagnosis of OSSN.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

Vempuluru

Pattnaik

Ghose

et al. 2021

European Journal of Ophthalmology

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“…Auto-inoculation is another proposed transmission mode, e.g., by hand carriage of genital HPV DNA [ 57 ]. Reports of co-existent genital- and conjunctival HPV-related neoplasia support autoinoculation as a transmission route to the conjunctiva [ 55 , 58 ].…”

Section: The Conjunctivamentioning

confidence: 99%

Human Papillomavirus Related Neoplasia of the Ocular Adnexa

Ramberg

Heegaard

2021

Viruses

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Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Due to the rarity of all these tumors, large studies are not available in the scientific literature, thereby hampering the precision of the HPV prevalence estimates and the ability to conclude. Nevertheless, increasing evidence supports that defined subsets of conjunctival papillomas, intraepithelial neoplasia, and carcinomas develop in an HPV-dependent pathway. The role of HPV in squamous cell tumors arising in the lacrimal drainage system and the eyelid is still uncertain. Further, the potential of HPV status as a diagnostic, prognostic, or predictive biomarker in these diseases is a topic for future research.

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Human papillomavirus (HPV)-associated trilateral squamous neoplasia in immunocompetent individual

Abstract: Simultaneous uterine and conjunctival HPV-related squamous neoplasia can occur in immunocompetent individuals. Auto-inoculation and repeated exposure to HPV could explain coexistence of different genotypes.

Cited by 2 publications

References 16 publications

Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

Human Papillomavirus Related Neoplasia of the Ocular Adnexa

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