Human papillomavirus (HPV) and rising oropharyngeal cancer incidence and survival in the United States.

Chaturvedi, Aditi; Engels, Eric A.; Pfeiffer, RM; Hernandez, Brenda Y.; Xiao, Weikai; Kim, E.; Jiang, Baoen; Goodman, MT; Sibug-Saber, Maria; Cozen, Wendy; Liu, L.; Lynch, Charles F.; Wentzensen, Nicolas; Jordan, Rick; Altekruse, Sean F.; Anderson, W.F.; Rosenberg, Per; Gillison, M. L.

doi:10.1200/jco.2011.29.15_suppl.5529

Cited by 23 publications

(24 citation statements)

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“…In our research we identify 15 articles focused on HPV associated oropharyngeal cancer and sexual behavior as a risk factor 1,3,9,[11][12][13][14][15][16][17][18][19][20][21][22] . One article studied the knowledge of HPV and its association with oropharyngeal cancer in a high-risk population 16 .…”

Section: Resultsmentioning

confidence: 99%

“…Chaturverdi et al 1 shown a HPV prevalence increasing from 16.3% during 1984 to 1989 to 71.7% during 2000 to 2004 and estimated that, if the incidence trend continue, the annual number of HPVpositive oropharyngeal cancers is expected to surpass the annual number of cervical cancers by the year 2020. In Latin America, Brazil, included, has a high incidence of oropharyngeal squamous cell carcinomas among both sex 23 and specifically in Brazil, more than two thirds of the oropharyngeal squamous cell carcinomas are diagnosed at late stage of the disease 24 and the survival rate for oral and oropharyngeal cancer in 5-years is less than 50% 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, HPV infection have been linked with a higher risk to develop oropharyngeal squamous cell carcinomas. Studies suggests that HPV is the main responsible for the increasing incidence of oropharyngeal squamous cell carcinomas even with decreasing tobacco consumption 1 .…”

Section: B) Hpv and Neoplasmsmentioning

confidence: 99%

“…Although smoking rates had been decreasing, there is an increase in the incidence of this kind of squamous cell carcinoma in this last years 1 . Recent studies suggest some of those Oropharyngeal squamous cell carcinomas are associated with human papillomavirus (HPV) infection, mainly the HPV16 type, a high-risk HPV.…”

Section: Introductionmentioning

confidence: 99%

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HPV positive oropharyngeal cancer: risky sexual behavior

Oliveira

Santos

Hojaij

2018

Rev. Med. (São Paulo)

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Rev Med (São Paulo ABSTRACT: Oropharyngeal squamous cell carcinomas have traditionally been associated with tobacco and alcohol use. Although smoking rates had been decreasing, there is an increase in the incidence of Oropharyngeal squamous cell carcinomas in the last years. This increase of Oropharyngeal squamous cell carcinomas is noticed in one specific type, Oropharyngeal squamous cell carcinomas associated with human papillomavirus (HPV) infection, mainly the HPV16 type, a high-risk HPV. Transmission of HPV is known as occur through sexual contact but many researches differ on which kind of sexual contact is the responsible for the HPV infection. Objective: The objective of this review is to verify in the literature if there is a pattern of sexual behavior that is more related with oropharyngeal squamous cell carcinoma HPV positive. The habits most associated with Oropharyngeal squamous cell carcinomas are oral sex and multiples sexual partners. The occurrence of this habits in the population varies from local culture, social status and ethnic group. In this context, health care professionals have a major responsibility in orientating about aspects of the disease, risk factors, vaccination and prognosis. Further researches are necessary to clarify the role of vaccination for HPV in future changes in the Oropharyngeal squamous cell carcinomas prevalence.Keywords: Oropharyngeal cancer; Papillomaviridae; Sexual behavior; Carcionma, squamous cell. RESUMO:O carcinoma de células escamosas de orofaringe é tradicionamente associado com uso de tabaco e álcool. Apesar da prevalência de tabagistas ter diminuído, a prevalência de carcinoma de células escamosas de orofaringe vem aumentando. Esse aumento do carcinoma de células escamosas de orofaringe pode ser notado em um tipo específico, o associado com infecção pelo papilomavirus humano (HPV), principalmente o HPV 16, um subtipo de HPV de alto risco. A transmissão do HPV é conhecidamente por contato sexual, mas muitas pesquisas diferem quanto ao tipo de contato responsável pela infecção pelo HPV. Objetivo: O objetivo dessa revisão é verificar se existe na literatura um padrão de comportamento sexual que está mais relacionado com o câncer de orofaringe HPV positivo. Os hábitos mais associados com carcinoma de células escamosas de orofaringe são realização de sexo oral e múltiplos parceiros sexuais. A ocorrência desses hábitos na população variam conforme a cultura local, nível social e grupos étnicos. Nesse contexto, profissionais de saúde têm grande responsabilidade na orientação sobre aspectos da doença, fatores de risco, vacinação e prognósticos. Outras pesquisas ainda são necessárias para determinar qual é o papel da vacinação contra HPV em futuras mudanças na prevalência do carcinoma de células escamosas de orofaringe.Descritores: Neoplasias orofaríngeas; Papillomaviridae; Comportamento sexual; Carcinoma de células escamosas. 99Oliveira DC, et al. HPV positive oropharyngeal cancer: risky sexual behavior.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: B) Hpv and Neoplasmsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HPV positive oropharyngeal cancer: risky sexual behavior

Oliveira

Santos

Hojaij

2018

Rev. Med. (São Paulo)

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“…Chaturvedi et al [3] Weiterhin konnte gezeigt werden, dass bezüglich des therapeutischen Einsatzes einer Radiotherapie HPV-positive Patienten mit Oropharynxkarzinomen im Gegensatz zu HPV-negativen Patienten einen besseren Verlauf aufwiesen (p = 0,002). Während die Inzidenz von HPV-positiven Oropharynxkarzinomen zwischen 1988 und 2004 um 225% stieg, konnte ein Rückgang der HPV-negativen Tumoren um 50% verzeichnet werden.…”

Section: » Eine Hpv-infektion Erhöht Das Relative Risiko Für Die Entsunclassified

Neue Aspekte HPV-positiver Kopf-Hals-Karzinome

Kofler

Uecker

Muenscher

et al. 2012

HNO

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HPV-positive head and neck carcinoma is significantly different than tobacco- and alcohol-induced cancer. Between 30% and 50% of oropharyngeal cancers are associated with human papillomavirus (HPV). Studies still show an increasing incidence. HPV-positive head and neck cancer patients have a better prognosis due to a better response to therapy. Especially patients with gene overexpression of immunological proteins in the antigen presentation are suggested to benefit from radiotherapy. A current retrospective study shows better outcomes for patients treated with radiotherapy in combination with biological targets compared to radiochemotherapy.

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Outcomes after primary intensity‐modulated radiation therapy for oropharyngeal squamous cell carcinoma at a New Zealand regional cancer centre: Impact of p16 status

et al. 2018

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Introduction:The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) in New Zealand is due to an increase in the numbers of human papilloma virus (HPV)-associated OPSCC. We evaluated the impact of positive p16 immunohistochemistry, as a surrogate for HPV positivity, on OPSCC outcomes after primary intensity-modulated radiotherapy (IMRT) with or without concurrent chemotherapy.Methods: Retrospective review was undertaken of electronic medical records of 90 patients with OPSCC who received primary IMRT with or without chemotherapy between 2008 and mid-2015 at the Regional Cancer Centre, Waikato Hospital, Hamilton, New Zealand.Results: Median age was 57.5 years. Immunohistochemistry for p16 was positive in 53 (59%) OPSCC while 37 (41%) had negative or unknown p16 status. Median radiotherapy dose was 70 Gy. Chemotherapy was administered to 78 (87%) patients, most receiving high-dose cisplatin.Nine patients had residual disease following treatment completion. Seven patients relapsed, and 26 died during the study period. Five patients with p16-positive OPSCC had persistent or recurrent disease. Actuarial 3-year locoregional control, disease-free survival, and overall survival for all patients were 80.7%, 74.7%, and 77.1%, respectively. Among p16-positive OPSCC patients, 3-year locoregional control, disease-free survival, and overall survival were 89.5%, 80.8%, and 90.9%, respectively.Conclusion: Outcomes after IMRT for OPSCC at Waikato Hospital are in line with the reported literature. Human papilloma virus-related OPSCC has better outcomes compared with patients with unknown or HPV-unrelated OPSCC. Trials are underway evaluating reduced intensity of treatment for HPV-related OPSCC.

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Human papillomavirus (HPV) and rising oropharyngeal cancer incidence and survival in the United States.

Cited by 23 publications

References 0 publications

HPV positive oropharyngeal cancer: risky sexual behavior

HPV positive oropharyngeal cancer: risky sexual behavior

Neue Aspekte HPV-positiver Kopf-Hals-Karzinome

Outcomes after primary intensity‐modulated radiation therapy for oropharyngeal squamous cell carcinoma at a New Zealand regional cancer centre: Impact of p16 status

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