Human Papillomavirus HPV-16 Dna as an Epitheliotropic Virus That Induces Hyperproliferation in Squamous Penile Tissue

Salazar, E. L.; Mercado, Efraı́n; Calzada, L

doi:10.1080/014850190923396

Cited by 13 publications

(9 citation statements)

References 14 publications

(13 reference statements)

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“…2,3,8,9,15,21,22,33,34,[38][39][40][41]47,50,52 Most reports validated the association of HPV with basaloid and warty carcinomas. 2,17,37 In some studies, about one-third of the usual and verrucous carcinomas were also reported to be positive for HPV.…”

Section: Discussionmentioning

confidence: 92%

“…1,37,44 There are many reports emphasizing the association of special subtypes of penile cancer and HPV but the prevalence figures are variable. 2,3,8,9,15,21,22,33,34,[38][39][40][41]47,50,52 The causes of these variations are not clear. They may be owing to real geographic differences in the overall incidence of HPV infection or HPV genotypes, to the use of different laboratorial techniques to detect HPV, to the original status of the paraffin blocks, to variable morphologic criteria used in the classification of penile tumors, or to other hidden reasons.…”

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confidence: 94%

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The Basaloid Cell is the Best Tissue Marker for Human Papillomavirus in Invasive Penile Squamous Cell Carcinoma: A Study of 202 Cases From Paraguay

Cubilla¹,

Lloveras²,

Alejo

et al. 2010

American Journal of Surgical Pathology

105

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Human papillomavirus (HPV) has been reported in 12-82% of penile squamous cell carcinomas (SCC). There is an association of the virus with basaloid and warty carcinomas but the reported prevalence is variable. The causes of these variations are not clear. They may be owing to geographic differences, the use of different techniques to detect HPV, the status of the original paraffin blocks, or to variable criteria in tumor classification. The aims of the study were to determine the prevalence of HPV in penile SCC and subtypes using a sensitive technique, to investigate genotypes involved, and to search for other morphologic features associated with the virus from a series of cases from Paraguay. HPV detection was done by SPF-10 polymerase chain reaction followed by DNA enzyme-immunoassay and genotyping by LIPA 25 (version 1). Samples were tested at Catalan Institute of Oncology, Barcelona, and cross testing was carried out at the Delft Diagnostic Laboratories in The Netherlands. HPV was detected in 64 of 202 cases (32%). Thirteen tumors had multiple HPV genotypes. Most prevalent genotypes were HPV-16 (46 cases), HPV-6 (6 cases), and HPV-18 (4 cases), either in single or in multiple infections. HPV was preferentially associated with warty-basaloid (82%), basaloid (76%), and warty (39%) carcinomas and not detected in verrucous, mixed verrucous-papillary, pseudohyperplastic, and pseudoglandular SCCs. There was a strong association between HPV and higher histologic grade. Basaloid cells were more frequently found in HPV positive tumors (72%) and this association was statistically significant in univariate and multivariate analyses. Cells with koilocytotic features and keratinizing squamous cells were also present but to a much lesser degree (47% and 19%, respectively). In summary, HPV was found in a third of the cases and the most common genotype was HPV-16. Low-risk genotypes were rarely found in single infections, representing 4 cases among all analyzed (2%). There was an association between HPV presence and higher histologic grade and with basaloid, warty-basaloid, and warty carcinomas. Our results also suggest that, in penile SCC, the basaloid cell is the best tissue marker for oncogenic HPV infection.

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Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 94%

The Basaloid Cell is the Best Tissue Marker for Human Papillomavirus in Invasive Penile Squamous Cell Carcinoma: A Study of 202 Cases From Paraguay

Cubilla¹,

Lloveras²,

Alejo

et al. 2010

American Journal of Surgical Pathology

105

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“…Publications containing less than five cases were also excluded from the analysis. A final total of 31 articles were included in this review12 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 45 (see table 1). …”

Section: Methodsmentioning

confidence: 99%

Human papillomavirus prevalence and type distribution in penile carcinoma

Miralles-Guri

Bruni

Cubilla³

et al. 2009

J Clin Pathol

294

182

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“…HPV DNA has been detected in 14%–100% of invasive penile carcinomas (Bezerra et al, 2001a; Chan et al, 1994; Cupp et al, 1995; Ferreux et al, 2003; Gregoire et al, 1995; Heideman et al, 2007; Humbey et al, 2003; Iwasawa et al, 1993; Krustrup et al, 2009; Levi et al, 1998; Lont et al, 2006; Maden et al, 1993; McCance et al, 1986; Nasca et al, 1999; Pascual et al, 2007; Picconi et al, 2000; Rubin et al, 2001; Salazar et al, 2005; Sarkar et al, 1992), with higher prevalence estimates among case series with small sample sizes. Differences in methods used for DNA detection and tumor tissue storage (fresh vs. paraffin embedded) and the inclusion of tumors with different histologic subtypes may contribute to the variation in HPV prevalence across studies.…”

Section: Hpv Prevalence In Penile Cancermentioning

confidence: 99%

Genital HPV infection and related lesions in men

Anic

Giuliano

2011

Preventive Medicine

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Human papillomavirus (HPV) is highly prevalent in men and there is an interest in further understanding the relationship between HPV infection and disease in men, including the development of genital warts, penile intraepithelial neoplasia and invasive penile carcinomas. Genital warts are caused by HPV 6/11 and are the most common clinical manifestation of HPV in men. Though they are benign and not associated with mortality, they are a source of psychosocial distress and physical discomfort. HPV infection can also develop into invasive penile carcinoma which is associated with morbidity and mortality. Approximately 40% of invasive penile carcinomas are attributable to HPV with HPV 16, 18, and 6/11 being the genotypes most commonly detected in penile tumors. Penile carcinomas of the basaloid and warty histologic subtypes are most likely to test positive for HPV. In addition to HPV infection, the risk factors most strongly associated with penile cancer are lack of neonatal circumcision, phimosis (the inability of uncircumcised men to fully retract the foreskin), and anogenital warts. Male vaccination with the quadrivalent HPV vaccine that protects against HPV 6/11/16/18 has been shown to significantly reduce HPV-associated anogenital infection and disease in men. If the quadrivalent vaccine is successfully disseminated to large segments of the young male population, there is the potential for substantial reduction in genital HPV infection and related lesions in men.

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Human Papillomavirus HPV-16 Dna as an Epitheliotropic Virus That Induces Hyperproliferation in Squamous Penile Tissue

Cited by 13 publications

References 14 publications

The Basaloid Cell is the Best Tissue Marker for Human Papillomavirus in Invasive Penile Squamous Cell Carcinoma: A Study of 202 Cases From Paraguay

The Basaloid Cell is the Best Tissue Marker for Human Papillomavirus in Invasive Penile Squamous Cell Carcinoma: A Study of 202 Cases From Paraguay

Human papillomavirus prevalence and type distribution in penile carcinoma

Genital HPV infection and related lesions in men

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