Human Papillomavirus Genotype Distribution in Cervical Intraepithelial Neoplasia Grade 2/3 and Invasive Cervical Cancer in Japanese Women

Azuma, Yoko; Kusumoto-Matsuo, Rika; Takeuchi, Fumihiko; Uenoyama, Asami; Kondo, Kazunari; Tsunoda, Hajime; Nagasaka, Kazunori; Kawana, Kei; Morisada, Tohru; Iwata, Takashi; Aoki, Daisuke; Kukimoto, Iwao

doi:10.1093/jjco/hyu112

Cited by 58 publications

(55 citation statements)

References 23 publications

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“…). Overall, HPV16 was most frequently detected by all three procedures, followed by HPV52, 31, 51, and 18, consistent with a previous report in Japan . Looking at the distribution patterns in more detail, single HPV16 infections were more often detected with F‐MGP (44.9%) than with C‐Chip (25.9%) or C‐MGP (35.4%).…”

Section: Resultssupporting

confidence: 89%

“…Two HPV vaccines, a quadrivalent vaccine targeting HPV6/11/16/18 and a bivalent vaccine targeting HPV16/18, are currently administered worldwide, and a nonavalent vaccine targeting five additional high‐risk genotypes, HPV31, 33, 45, 52, and 58, together with HPV6/11/16/18, has been introduced in the USA, Canada, and Europe . Because a higher prevalence of non‐HPV16/18 genotypes is observed in precancerous cervical lesions and cervical cancers in East Asian countries, including Japan, the nonavalent HPV vaccine will be valuable if it is proven sufficiently effective …”

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confidence: 99%

“…(4,5) Because a higher prevalence of non-HPV16/18 genotypes is observed in precancerous cervical lesions and cervical cancers in East Asian countries, including Japan, the nonavalent HPV vaccine will be valuable if it is proven sufficiently effective. (6,7) The most appropriate method for determining the causal attribution of individual HPV genotypes in cervical lesions when HPV prevalence is monitored in clinical and epidemiological settings is controversial. Some researchers use formalin-fixed paraffin-embedded (FFPE) tissues, (1,6,8) whereas others use exfoliated cervical cells.…”

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Comparison of methods using paraffin‐embedded tissues and exfoliated cervical cells to evaluate human papillomavirus genotype attribution

Torii

Fujii²,

Kukimoto

et al. 2016

Cancer Science

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Monitoring the attribution of human papillomavirus (HPV) genotypes to cervical precancerous lesions is essential in assessing the efficacy of HPV vaccines. To resolve the lack of studies comparing the HPV genotyping procedures used to estimate HPV genotype attribution, we undertook a retrospective cross‐sectional study to determine the appropriate genotyping procedures for evaluating the potential efficacy of HPV vaccines. Three procedures, including two different genotyping methods, Clinichip HPV test (C‐Chip) and modified GP5+/6+ PCR coupled to fluorescent bead sorter detection (MGP), using exfoliated cervical cells (C‐Chip and C‐MGP, respectively) or formalin‐fixed paraffin‐embedded tissues (F‐MGP), were compared. The overall agreement in detecting high‐risk HPV was 88.5–92.1% among the three procedures, and genotype‐specific agreement was 83.9–100% for all pairwise comparisons. In cervical intraepithelial neoplasia grade 2/3 specimens, HPV16/18 attribution estimated with the hierarchical attribution method was consistent among the procedures: 52.3% (45/86) for C‐Chip, 54.7% (47/86) for C‐MGP, and 52.3% (45/86) for F‐MGP (P = 0.81). HPV16/18/31/33/45/52/58 hierarchical attribution was 88.4% (76/86) with C‐Chip, 86.0% (74/86) with C‐MGP, and 83.7% (72/86) with F‐MGP (P = 0.49). In cervical intraepithelial neoplasia grade 3 specimens, the corresponding hierarchical attribution was 96.4% (53/55) with C‐Chip, 89.1% (49/55) with C‐MGP, and 94.5% (52/55) with F‐MGP (P = 0.27). Although F‐MGP is theoretically a reliable method for determining HPV genotype attribution, it is acceptable to use C‐Chip or C‐MGP, coupled to the hierarchical attribution formula to correct the bias of multiple infections. These approaches using exfoliated cervical cells are practical for monitoring the efficacy of HPV vaccines.

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Section: Resultssupporting

confidence: 89%

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confidence: 99%

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confidence: 99%

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Comparison of methods using paraffin‐embedded tissues and exfoliated cervical cells to evaluate human papillomavirus genotype attribution

Torii

Fujii²,

Kukimoto

et al. 2016

Cancer Science

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“…However, 40% of CIN2 lesions persist, whereas only ∼33% of CIN3 lesions regress, and 12% to 20% of them progress to cervical cancer. 38,39 In contrast, a CIN1 diagnosis is not a significant risk factor for CIN3 beyond the risk attributed to molecular cause and genotype-specific HPV infection. 40 In addition, other factors 11,15 may be associated with the progression of CIN1 to CC, including the hr-HPV DNA load; age at first intercourse; high parity; smoking; endogenous and exogenous hormonal factors, such as parity, oral contraceptive use, and obesity; and infection with other sexually transmitted infectious agents, such as herpes simplex virus 2; however, these were not included or discussed in our study because HPV infection is the key risk factor in the development of cervical lesions and because no study has analyzed the hr-HPV distribution in the Han population of Beijing, China, based on histopathology results.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Human Papillomavirus Genotypes Among Women With High-Grade Cervical Lesions in Beijing, China

Xiao

et al. 2016

Medicine

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The aim of the study is to investigate the prevalence of high-risk human papillomavirus (hr-HPV) genotypes among Han women with high-grade cervical lesions in Beijing, China.Cervical cell specimens from patients with histopathologically confirmed cervical lesions at 7 hospitals in Beijing were examined with a validated HPV kit for 13 hr-HPV genotypes during the study period. The patients were divided into a low-grade cervical lesions group (cervical intraepithelial neoplasia grade 1, CIN1) and a high-grade cervical lesions group (CIN2+, including cervical intraepithelial neoplasia grade 2, CIN2; cervical intraepithelial neoplasia grade 3, CIN3; squamous cervical cancer, SCC; and adenocarcinoma of the cervix, ACC) based on the histopathology results.A total of 2817 eligible patients were enrolled, including 610 cases identified as CIN1 and 2207 as CIN2+. The hr-HPV positive rates in the CIN1 and CIN2+ groups were 78.2% (477/610) and 93.3% (2060/2207), respectively. The most frequently detected genotypes were HPV16, 58, 52 and18 in the CIN1 group and HPV16, 58, 33, and 52 in the CIN2+ group, in descending order of prevalence. In addition, the prevalence of HPV18 among the patients with ACC was 28.6% (14/49), significantly >7.2% (54/752) prevalence among the SCC patients (P < 0.001). Additionally, significantly more women in the CIN2+ group had multiple infections compared with those in the CIN1 group (38.1% and 24.9%, respectively; P < 0.001). However, as the cervical lesion grade increased, the prevalence of multiple hr-HPV infections gradually deceased to 44.2% in the CIN2 patients, 36.7% in the CIN3 patients, and 35.3% in the cervical cancer (CC) patients, which included SCC and ACC patients. In cases of multiple hr-HPV infections in the CIN2+ group, double infections accounted for ∼76.6%, and HPV16+58, HPV16+52, and HPV16+18 were the most common combinations, in descending order. The most frequent combination for triple infections was HPV16+58+31, with a rate of 4.2%. The highest positive rate occurred in the ≤24 year-old group for all types of cervical lesions.The prevalence of HPV genotypes in the targeted population with high-grade cervical lesions differs from that of other countries. This information could be helpful for the prevention of CC in Beijing, China.

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“…In this assay, 31 HPV types (HPV6, 11, 16, 18, 26, 31, 33, 34, 35, 39, 40, 42, 44, 45, 51, 52, 53, 54, 55, 56, 57, 58, 59, 66, 68, 69, 70, 73, 82, 83 and 84) were detected. Our genotyping quality was equivalent to that of genotyping system used in the National Institute of Infectious Diseases in Japan, which had been evaluated as proficient in the HPV DNA proficiency panel study conducted by WHO HPV Laboratory Network …”

Section: Methodsmentioning

confidence: 99%

Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology

Ueda

Kawana

Yanaihara

et al. 2019

J of Obstet and Gynaecol

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Aim In Cambodia, the Japan Society of Obstetrics and Gynecology and the Cambodian Society of Gynecology and Obstetrics have an on‐going project, started in 2015, for cervical cancer prevention and treatment. The project, currently aimed at factory workers, includes a women’s health education program that leads into cervical cancer prevention by establishment of a system for early detection and treatment. It begins by health education, screening for human papillomavirus (HPV), followed by colposcopy and quicker treatment of earlier precursor lesions. Methods Rates for participant screening, HPV test positivity, cervical intraepithelial neoplasia (CIN) detection and distribution of HPV types were compared between two screening programs, factory‐based and hospital‐based. Some HPV test samples were divided into two, one of which was sent to Japan for a quality‐control check of the Cambodian testing. Results The factory‐based participant screening rate was 19% (128/681). HPV was detected more frequently in the factory‐based program participants (12%) than in the hospital‐based program participants (5%). Unfortunately, however, the rate of receiving proper secondary colposcopy screening among the HPV‐positive females was significantly higher in the hospital‐based program (94%) than the factory‐based program (40%) ( P < 0.001). The Cambodian laboratory HPV testing accuracy was 92.6%. HPV types demonstrated no significant difference between the two prevention programs. Conclusion We could successfully introduce HPV‐based screening, starting from health education. However, low rate of screening, especially secondary screening for HPV positive factory workers was identified. Also, HPV testing could be further improved for accuracy through close monitoring.

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Human Papillomavirus Genotype Distribution in Cervical Intraepithelial Neoplasia Grade 2/3 and Invasive Cervical Cancer in Japanese Women

Abstract: The results of this study provide pre-vaccination era baseline data on human papillomavirus type distribution in Japanese women and serve as a reliable basis for monitoring the future impact of human papillomavirus vaccination in Japan.

Cited by 58 publications

References 23 publications

Comparison of methods using paraffin‐embedded tissues and exfoliated cervical cells to evaluate human papillomavirus genotype attribution

Comparison of methods using paraffin‐embedded tissues and exfoliated cervical cells to evaluate human papillomavirus genotype attribution

Prevalence of Human Papillomavirus Genotypes Among Women With High-Grade Cervical Lesions in Beijing, China

Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology

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