Human papillomavirus found in sperm head of young adult males affects the progressive motility

Foresta, Carlo; Garolla, Andrea; Zuccarello, Daniela; Pizzol, Damiano; Moretti, Afra; Barzon, Luisa; Palù, Giorgio

doi:10.1016/j.fertnstert.2008.10.050

Cited by 126 publications

(157 citation statements)

References 19 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…However, this study is more comprehensive than the previous one because it was possible to investigate bull semen from a large number of farms, 20 in a total, and this study was developed in an extensive area of 300 km radius. In the case of humans, several studies have found the presence of HPV in semen [2,8,9,19,26].We demonstrated the presence of E2 and E5-BPV2 transcripts in sperm cells of bulls. Previous studies showed the expression of E5 oncogene in other non-epithelial tissue, such as blood cells [4,28] and semen [34].…”

supporting

confidence: 54%

See 1 more Smart Citation

Bovine papillomavirus E2 and E5 gene expression in sperm cells of healthy bulls

Silva

Gurgel

et al. 2013

VirusDis.

View full text Add to dashboard Cite

Papillomaviruses are found in epithelial lesions and are linked to different carcinogenic processes in humans and other animals. Although BPV has been characterized as epitheliotropic, the presence of viral DNA has been detected in other tissues and fluids, such as fresh semen. The aim of this study was to evaluate the presence and expression of BPV in sperm cells of bulls (Bos taurus) asymptomatic for papillomatosis. A PCR assay was carried out with specific primers to test BPV2 in 26 semen samples. The presence of BPV transcripts was assessed by RT-PCR to E2 and E5 genes. BPV2 DNA was detected in nine out of 26 samples and the expression of E2 and E5 were detected in five out of nine BPV positive samples. This is the first record of BPV2 expression in bull sperm cells.Keywords Bovine papillomavirus Á Semen Á Viral gene expression Papillomaviruses (PVs) are double-stranded DNA tumour viruses identified in a broad range of animal species that belongs to the amniotes, including human being [1]. So far, 13 genotypes of Bovine papillomavirus (BPV1-13) have been characterized [21] and classified in three different genera: Deltapapillomaviruses (BPV1 and 2), Epsilonpapillomaviruses (BPV5 and 8) and Xipapillomaviruses (BPV3, 4, 6, 9, 10 and 11). BPV7 is classified as an unassigned PV genus [12,14]. BPVs from Delta-PVs and BPV5 can infect epithelial and subepithelial fibroblasts inducing fibro-epithelial tumours in cattle, known as fibropapillomas while BPVs from another genus can induce true papillomas [22]. Normally, papillomas regress as a result of cellmediate immune response [17]. However, occasionally papillomas may develop in squamous cell carcinoma as a result of involvement of environmental and genetic cofactors [3,5]. Recently, the co-infection among BPVs in skin lesions (warts) has been described, but the real significance of this finding need to be clarified [7,25,31].PVs are described as epitheliotropic viruses, although their presence has been detected in different tissues and cells [11,20,36]. Few studies have contributed to improved understanding of PV transmission, however, its spread through non-epithelial, however, its spreading of through non-epithelial tissues and fluids has been suggested [6,11].In humans, infected sperm are able to penetrate the oocyte, to deliver HPV genome in the oocyte and HPV genes can be actively transcribed by the fertilized oocyte [10]. There are few reports focusing on the study of BPV in reproductive tract and its cells [13,35] although the BPV-1 were described in the prepuce and penis [16] and BPV-2 were found infecting placenta and actively expressed in equine semen [30,34]. In an early study, we demonstrate the high incidence of BPV2 in commercial doses of bull semen from national and multinational companies [33]. However, studies are needed to understand the biological significance of BPV presence in semen. The present study aimed to evaluate the presence of BPV in sperm cells of healthy bull, as well as the viral gene expression. The semen was collected fro...

show abstract

supporting

confidence: 54%

mentioning

confidence: 99%

Bovine papillomavirus E2 and E5 gene expression in sperm cells of healthy bulls

Silva

Gurgel

et al. 2013

VirusDis.

View full text Add to dashboard Cite

show abstract

“…They have been categorized as either low-risk types (lrHPV) or highrisk types (hrHPV) depending on their oncogenic potential [2]. Following HPV types are considered as high risk: 16,18,31,33,35,39,45,51,52,56,58,59 68, 73, and 82. Types 26,53, and 66 are considered as probable high risk (phr).…”

Section: Human Papillomavirus (Hpv) Is the Most Common Sexually Transmentioning

confidence: 99%

Human Papillomavirus in Donor Semen in Belgium

D’Hauwers¹,

Tjalma²,

Punjabi³

et al. 2012

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

View full text Add to dashboard Cite

“…A transmissão peri-conceptual pode teoricamente ocorrer através do oócito infectado (CAMPOS et al, 2016) ou espermatozoide (SYRJÃNEN, 2010), o DNA do HPV já foi detectado no sémen (FORESTA et al, 2010), endométrio e ovários (LAI et al, 1992), sugerindo que essa transmissão pode ocorrer durante a fertilização ou imediatamente após (FREITAS et al, 2015).…”

Section: Transmissão Do Hpvunclassified

“…Já foi possível realizar a detecção do vírus no sangue periférico (BODAGHI et al, 2005;TSENG et al, 1999;), placenta (FREITAS et al, 2013), sêmen (FORESTA et al, 2010), oócito (CAMPOS et al, 2016). Além do DNA do HPV, transcritos do vírus já foram detectados em outros sítios, incluindo o sangue periférico (DONG et al, 2002;PAO et al, 1997).…”

Section: Transcritos Virais Nos Sítios De Infecçãounclassified

Atividade mucosotrópica do Papilomavírus Humano (HPV) no processo carcinogênico em diferentes sítios de infecção.

Sant’Ana¹

View full text Add to dashboard Cite

Human papillomavirus found in sperm head of young adult males affects the progressive motility

Cited by 126 publications

References 19 publications

Bovine papillomavirus E2 and E5 gene expression in sperm cells of healthy bulls

Bovine papillomavirus E2 and E5 gene expression in sperm cells of healthy bulls

Human Papillomavirus in Donor Semen in Belgium

Atividade mucosotrópica do Papilomavírus Humano (HPV) no processo carcinogênico em diferentes sítios de infecção.

Contact Info

Product

Resources

About