Human papillomavirus DNA strongly correlates with a poorer prognosis in oral cavity carcinoma

Duray, Anaelle; Descamps, Géraldine; Decaestecker, Christine; Remmelink, Myriam; Sirtaine, Nicolas; Lechien, Jérôme R.; Ernoux-Neufcoeur, Perle; Blétard, Noëlla; Somja, Joan; Depuydt, Christophe; Delvenne, Philippe; Saussez, Sven

doi:10.1002/lary.23298

Cited by 97 publications

(92 citation statements)

References 47 publications

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“…In contrast to the clear picture in OPC [7,51,62], where the prognostic relevance of biologically active HPV infection is established, no such clear association has been found in OCSCC. Published literature is divided between the improved likelihood for HPV-positive OCSCC on one hand [63,64] and worst outcome on the other [65][66][67] with no clout on patient survival [10,37,68].…”

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

Singh

Kushwaha

Anand

et al. 2016

Indian J Surg Oncol

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Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment. A total of 43 primary OCSCC biopsy specimens were collected. These samples were analyzed for HPV DNA genotyping which was done by using 13 high-risk HPV real-time PCR kits. Quality of life was assessed using University of Washington questionnaire for HNC patients, which was administered pretreatment and 3-months posttreatment. HPV presence was confirmed in only three patients (7.0 %). HPV positivity did not find any statistical correlation with age, gender, residence, addiction habit, stage, tumor size, nodal status, tumor grade, and number of sexual contacts. There was no significant (p > 0.05) difference in the average percent change in QOL parameters from pretreatment to posttreatment when correlated with HPV status.

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Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

Singh

Kushwaha

Anand

et al. 2016

Indian J Surg Oncol

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“…30 Three published studies report that HPV þ oral cavity squamous cell carcinoma are associated with poorer prognosis; two studies are from the same group in Taiwan and include an expanded cohort. [46][47][48] The strengths of the combined Taiwanese study are the large patient numbers and multivariate analysis; study weaknesses include the lack of p16 INK4a analysis and absence of validation for the HPV genotype data. The Taiwan study demonstrated an overall HPV prevalence of 21.2% among 410 patients; HPV16 was the most common subtype followed by HPV18.…”

Section: Discussionmentioning

confidence: 99%

“…As mentioned, HPV was genotyped using only a blot hybridization assay, and not validated. 47 Duray et al 48 reported on 147 patients with oral cavity squamous cell carcinoma; HPV was detected by PCR with consensus and type-specific primers. HR-HPV was associated with decreased disease-free survival on KaplanMeier analysis; no multivariate analysis was performed.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of p16INK4a in oral cavity carcinomas: p16Ink4A dampens tumor invasion—integrated analysis of expression and kinomics pathways

Isayeva

Ragin

et al. 2015

Modern Pathology

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A large body of evidence shows that p16 INK4a overexpression predicts improved survival and increased radiosensitivity in HPV-mediated oropharyngeal squamous cell carcinomas.(OPSCC). Here we demonstrate that the presence of transcriptionally active HPV16 in oral cavity squamous cell carcinomas does not correlate with p16 INK4a overexpression, enhanced local tumor immunity, or improved outcome. It is interesting that HPVmediated oropharyngeal squamous cell carcinomas can be categorized as having a 'nonaggressive' invasion phenotype, whereas aggressive invasion phenotypes are more common in HPV-negative squamous cell carcinomas. We have developed primary cancer cell lines from resections with known pattern of invasion as determined by our validated risk model. Given that cell lines derived from HPV-mediated oropharyngeal squamous cell carcinomas are less invasive than their HPV-negative counterparts, we tested the hypothesis that viral oncoproteins E6, E7, and p16 INK4a can affect tumor invasion. Here we demonstrate that p16 INK4a overexpression in two cancer cell lines (UAB-3 and UAB-4), derived from oral cavity squamous cell carcinomas with the most aggressive invasive phenotype (worst pattern of invasion type 5 (WPOI-5)), dramatically decreases tumor invasiveness by altering expression of extracellular matrix remodeling genes. Pathway analysis integrating changes in RNA expression and kinase activities reveals different potential p16 INK4a -sensitive pathways. Overexpressing p16 INK4a in UAB-3 increases EGFR activity and increases MMP1 and MMP3 expression, possibly through STAT3 activation. Overexpressing p16 INK4a in UAB-4 decreases PDGFR gene expression and reduces MMP1 and MMP3, possibly through STAT3 inactivation. Alternatively, ZAP70/Syk might increase MUC1 phosphorylation, leading to the observed decreased MMP1 expression.

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“…Cependant, les patients fumeurs HPV+ ont un moins bon pronostic que les patients HPV+ non fumeurs [22,23]. Quelques travaux, plus rares, ont trouvé une corrélation inverse entre une infection par HPV et la survenue d'une récidive ou la survie [24,25]. La surexpression de p16 par les cellules tumorales est aussi associée à un meilleur pronostic, même dans les tumeurs où une infection par HPV n'est pas retrouvée [26].…”

Section: Hpv Et Cancers Des Vads : Données Cliniquesunclassified

Les cancers des voies aérodigestives supérieures associés aux papillomavirus

et al. 2013

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Human papillomavirus DNA strongly correlates with a poorer prognosis in oral cavity carcinoma

Abstract: A high prevalence of hr and lr HPV infections was detected in the OSCC patients included in the study. Moreover, hr HPV positivity was correlated with a decreased 5-year disease-free survival rate compared with HPV- and lr HPV+.

Cited by 97 publications

References 47 publications

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

The protective effect of p16INK4a in oral cavity carcinomas: p16Ink4A dampens tumor invasion—integrated analysis of expression and kinomics pathways

Les cancers des voies aérodigestives supérieures associés aux papillomavirus

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