Human papillomavirus detected in female breast carcinomas in Japan

Khan, Noureen; Castillo, Andrés; Koriyama, Chihaya; Kijima, Y; Umekita, Yoshihisa; Ohi, Yoshitada; Higashi, Michiyo; Sagara, Yoshiatsu; Yoshinaka, Heiji; Tsuji, Takahiro; Natsugoe, Shouji; Douchi, Tsutomu; Eizuru, Yoshito; Akiba, Suminori

doi:10.1038/sj.bjc.6604502

Cited by 108 publications

(149 citation statements)

References 41 publications

(53 reference statements)

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…However, there are studies evaluating the controversial presence of Human papillomavirus in breast lesions and the reported prevalence of HPV infection in breast cancer shows a great variation worldwide. Demographic features, genetic backgrounds, numbers of samples tested, methodological differences, low viral loads and the sensitivity of methods used, may be attributed to the difference of HPV prevalence in breast carcinomas in different reports (Khan et al, 2008). Still, there is insufficient data about the role of HPV in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

No Detection of 'High-risk' Human Papillomaviruses in a Group of Iranian Women with Breast Cancer

Ahangar-Oskouee¹,

Shahmahmoodi²,

Jalilvand³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Asian Pac J Cancer Prev, 15 (9), [4061][4062][4063][4064][4065] IntroductionBreast cancer is the second most common cancer in the world, accounts for 25% of all cancers (excluding nonmelanoma skin cancers) in women (GLOBOCAN, 2012). According to recently published data, the overall cancer incidence in Iran has been 110 per 100,000 in men and 98 per 100,000 in women in 2006. Among Iranian women, breast cancer is the leading cause of cancer morbidity and mortality, even though its incidence is among the lowest in the world, i.e., 25 per 100,000 (Mousavi et al., 2008).Breast cancer affects Iranian women at least one decade younger than their counterparts in developed countries (Harirchi et al., 2004). There are many published studies about breast cancer in Iran, but the epidemiological aspects of Iranian breast cancer are uncertain.Well known risk factors of breast cancer are genetic and epigenetic factors including: mutations in breast cancer susceptibility genes BRCA1 and BRCA2, TP53, sex-steroid hormones and lifestyle factors (Hulka and Moorman, 2008;Derks-Smeets et al., 2014).

show abstract

Section: Discussionmentioning

confidence: 99%

No Detection of 'High-risk' Human Papillomaviruses in a Group of Iranian Women with Breast Cancer

Ahangar-Oskouee¹,

Shahmahmoodi²,

Jalilvand³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…The controversy surrounding the role of HPV in breast cancer may be because of the difficulty that has been encountered in detecting the virus in breast specimens, in contrast to the relative ease of detection in cervical cancers (Lindel et al, 2007;Khan et al, 2008). Indeed, in a previous study from our group, we demonstrated that it was necessary to use SYBR Green I (Molecular Probes, Carlsbad, CA, USA) for polymerase chain reaction (PCR) detection of virus in breast cancer in DNA extracted from breast tissue (Kan et al, 2005).…”

mentioning

confidence: 99%

“…Previous studies have demonstrated the presence of HPV high-risk types 16, 18 and 33 in breast cancer specimens from diverse populations around the world: Italy, Norway, China, Japan, USA, Austria, Brazil, Australia, Taiwan, Turkey, Greece, Korea, Mexico, Hungary and Syria (Lonardo et al, 1992;Hennig et al, 1999;Yu et al, 1999;Liu et al, 2001;Damin et al, 2004;Widschwendter et al, 2004;de Villiers et al, 2005;Kan et al, 2005;Tsai et al, 2005;Gumus et al, 2006;Kroupis et al, 2006;Lawson et al, 2006;Choi et al, 2007;Akil et al, 2008;Khan et al, 2008;Kulka et al, 2008;MendizabalRuiz et al, 2009). The prevalence of HPV positive breast cancer in these studies was reported to vary from 4% in Mexican to 86% in American women.…”

mentioning

confidence: 99%

Human papilloma virus is associated with breast cancer

et al. 2009

View full text Add to dashboard Cite

BACKGROUND: There is increasing evidence that high-risk human papilloma virus (HPV) is involved in cancers in addition to cervical cancer. For example, it is generally accepted that HPV has a role in a significant proportion of head and neck tumours, and it has long been hypothesised that hormone dependent oncogenic viruses, such as HPV may have causal roles in some human breast cancers. A number of reports have identified HPV DNA in breast tissue and breast cancer specimens, but these rely on standard polymerase chain reaction (PCR), which is criticised for its propensity for contamination. METHODS: We have used two different technologies, in situ and standard PCR (with sequencing), and histology based on light microscopy. RESULTS: We unambiguously demonstrate the presence of high-risk HPV in the cells of breast cancer specimens and breast cancer cell lines. In addition, we also show that the oncogenic characteristics of HPV associated breast cancer are very similar to HPV-associated cervical cancer. Specifically, that putative koilocytes are present in some HPV associated breast cancers. INTERPRETATION: The above observations indicate a likely causal role for high-risk HPV in human breast cancer and offer the possibility of primary prevention of some breast cancers by vaccination against HPV.

show abstract

“…En la paciente con patología benigna infectada por el VPH se identificó el genotipo 33, de alto riesgo oncogénico. Estos genotipos identificados coinciden con los reportados en el resto del mundo, donde el genotipo de alto riesgo oncogénico más frecuentemente detectado es el 16, en un 20 a un 90% de los casos 21,35 . Agrupando los genotipos virales según su riesgo oncogé-nico, obtuvimos que el 28.57% de las pacientes con cáncer de mama presentó infección única por genotipos de alto y bajo riesgo, respectivamente, y el 42.90% de las pacientes positivas para VPH presentó coinfección por ambos grupos de genotipos.…”

Section: Discussionunclassified

Presencia del virus del papiloma humano y del virus de Epstein-Barr en biopsias de cáncer de mama como posibles factores de riesgo

Ladera

Fernándes

López

et al. 2022

GAMO

View full text Add to dashboard Cite

Recibido el 8 de octubre de 2016; aceptado el 25 de febrero de 2017 Disponible en Internet el 4 de agosto de 2017Resumen Introducción: El cáncer de mama en Venezuela representa la primera causa de muerte oncológica en la población femenina. Se han reportado muchos factores de riesgo que favorecen su aparición; sin embargo, en las últimas décadas el virus del papiloma humano (VPH) y el virus de Epstein-Barr (VEB) se han asociado como posibles factores de riesgo en el desarrollo de esta malignidad. Objetivo: Detectar la presencia de VPH y VEB en biopsias de cáncer de mama, para establecer una posible relación entre la infección por estos agentes virales y el desarrollo de esta patología. Métodos: Se recolectaron biopsias frescas de pacientes con cáncer de mama y de pacientes con patología benigna de la mama, que asistieron a cirugía en el Hospital Universitario de Caracas. Se realizaron la detección y la tipificación de VPH mediante el estuche comercial INNOLIPA ® HPV Genotyping Extra (Innogenetics), y se detectó el genoma del VEB mediante el estuche comercial Epstein-Barr virus BMLF1 (Maxim Biotech, Inc.). Resultados: El 63,6 y el 13,6% de los casos de cáncer de mama fueron positivos para ADN de VPH y VEB, respectivamente, mientras que las muestras de patología benigna presentaron un 4,5% de positividad para cada uno de los virus. El 42,9% de las muestras de cáncer de mama presentó infección mixta con genotipos de alto y bajo riesgo oncogénico de VPH. Conclusión: Podemos sugerir que el VPH y el VEB representan importantes factores de riesgo para el cáncer de mama, pero son necesarios estudios que permitan dilucidar mejor el papel de estos virus en el desarrollo de la enfermedad. (creativecommons.org/licenses/by-nc-nd/4.0/).

show abstract

Human papillomavirus detected in female breast carcinomas in Japan

Cited by 108 publications

References 41 publications

No Detection of 'High-risk' Human Papillomaviruses in a Group of Iranian Women with Breast Cancer

No Detection of 'High-risk' Human Papillomaviruses in a Group of Iranian Women with Breast Cancer

Human papilloma virus is associated with breast cancer

Presencia del virus del papiloma humano y del virus de Epstein-Barr en biopsias de cáncer de mama como posibles factores de riesgo

Contact Info

Product

Resources

About