Human papillomavirus correlates of high grade cervical dysplasia among HIV-Infected women at a major treatment centre in Nigeria: a cross-sectional study

Yakub, Martin Maimako; Fowotade, Adeola; Anaedobe, Chinenye Gloria; Manga, Mohammed Mohammed; Bakare, Rasheed; Abimiku, Bawa Ahmed

doi:10.11604/pamj.2019.33.125.17589

Cited by 10 publications

(16 citation statements)

References 29 publications

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“…This demonstrates the increasing prevalence of HPV with an increase in cervical intraepithelial lesions [33,35]. A prevalence of 20.7% was noted for precancerous lesions in HIV-infected women in this study which is comparable to 25% reported in Nigeria [23].…”

Section: Discussionsupporting

confidence: 79%

“…This type is associated with precancerous and cancerous lesions [39]. High HPV 35 prevalence was also recorded in Nigeria [23]. The high HPV prevalence of HPV 31 was recorded in HSIL and ASCUS in HIV-infected women in this study.…”

Section: Discussionsupporting

confidence: 59%

“…Results elsewhere also indicate HPV 35 is associated with malignancies even in younger HIV-uninfected women [32]. In a study in Nigeria, HPV 35 was the most prevalent in HIV-infected women [23]. HPV 52 had a high prevalence in a study done in Western Kenya in HIV-infected women [41].…”

Section: Discussionmentioning

confidence: 99%

“…Determine™ HIV rapid test was used as the first rapid test for all participants; all cases reactive to Determine™ were screened again using the second rapid test UniGold™. In case of indeterminate results, 3 ml of blood was collected for an ELISA test to confirm the HIV status at the Kenya Medical Research Institute [23].…”

Section: Biological Specimenmentioning

confidence: 99%

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Cervical Dysplasia, Infection, and Phylogeny of Human Papillomavirus in HIV-Infected and HIV-Uninfected Women at a Reproductive Health Clinic in Nairobi, Kenya

Omire

Budambula

Kirumbi

et al. 2020

BioMed Research International

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High risk human Papillomavirus (HPV) infections ultimately cause cervical cancer. Human Immunodeficiency Virus (HIV) infected women often present with multiple high-risk HPV infections and are thus at a higher risk of developing cervical cancer. However, information on the circulating high-risk HPV genotypes in Kenya in both HIV-infected and HIV-uninfected women is still scanty. This study is aimed at determining the phylogeny and the HPV genotypes in women with respect to their HIV status and at correlating this with cytology results. This study was carried out among women attending the Reproductive Health Clinic at Kenyatta National Hospital, a referral hospital in Nairobi, Kenya. A cross-sectional study recruited a total of 217 women aged 18 to 50 years. Paired blood and cervical samples were obtained from consenting participants. Blood was used for serological HIV screening while cervical smears were used for cytology followed by HPV DNA extraction, HPV DNA PCR amplification, and phylogenetic analysis. Out of 217 participants, 29 (13.4%) were HIV seropositive, while 68 (31.3%) were positive for HPV DNA. Eight (3.7%) of the participants had abnormal cervical cytology. High-risk HPV 16 was the most prevalent followed by HPV 81, 73, 35, and 52. One participant had cervical cancer, was HIV infected, and had multiple high-risk infections with HPV 26, 35, and 58. HPV 16, 6, and 81 had two variants each. HPV 16 in this study clustered with HPV from Iran and Africa. This study shows the circulation of other HPV 35, 52, 73, 81, 31, 51, 45, 58, and 26 in the Kenyan population that play important roles in cancer etiology but are not included in the HPV vaccine. Data from this study could inform vaccination strategies. Additionally, this data will be useful in future epidemiological studies of HPV in Nairobi as the introduction or development of new variants can be detected.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Biological Specimenmentioning

confidence: 99%

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Cervical Dysplasia, Infection, and Phylogeny of Human Papillomavirus in HIV-Infected and HIV-Uninfected Women at a Reproductive Health Clinic in Nairobi, Kenya

Omire

Budambula

Kirumbi

et al. 2020

BioMed Research International

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“…Knowing that a great majority of invasive CC are preventable thanks to refined access to high-functioning HPV testing, a routine targeted screening would significantly decrease the burden of CC among HIV(+) women. [46] HPV presence and HIV acquisition While it has been clearly showed that HIV presence is a risk factor for HPV acquisition, some researchers started to consider the opposite correlation, in which the HPV infection might have been the risk factor for HIV acquisition. It has been estimated that HIV acquisition rate is almost two times higher among HPV(+) individuals in comparison to HPV(-) counterparts.…”

Section: Screening Of Cervical Cancer Among Hiv-positive Womenmentioning

confidence: 99%

Relationship between HPV and HIV. Prevalence, molecular mechanisms and screening of HPV among HIV infected women

Kosz¹,

Zielińska²,

Kuchnicka³

et al. 2020

J Educ Health Sport

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Introduction: Human papillomavirus (HPV) and human immunodeficiency virus (HIV) are the most common sexually transmitted infections (STI) globally. According to the World Health Organisation (WHO) there are around 17.4 million women living with HIV and over 290 million HPV infected women worldwide. Purpose: This review is to summarize available data concerning the relationship between HIV and HPV infection among women. The analysis comprises molecular mechanisms of HPV infection among HIV(+) women as well as HIV infection among HPV(+) women, prevalence of HPV and cervical lesions among women living with HIV and screening of HPV and cervical cancer (CC) among HIV infected women. Material and methods: The review includes publications from 2011 to 2020. The dat a has been collected by the use of the PubMed, Ovid, Up-To-Date and WHO website. Key words used to search for references include: HPV, HIV, prevalence, molecular mechanism, screening. Results: HIV infection is a risk factor for HPV acquisition. On the one hand, prevalence of HPV, multiple HPV, high risk HPV (hrHPV) infections and cervical intraepithelial neoplasia (CIN) is higher among HIV(+) women. On the other hand, HPV infection can also predispose to HIV acquisition. Evidence on how these viruses influence each other can be a breakthrough in the range of prevention, detection and treatment of both HIV and HPV infection. Conclusions: Relationship between HPV and HIV is an interest of nowadays medicine. Possibly, these viruses may cooperate and enable infection of each other. It has been showed that the prevalence of HPV, multiple HPV, hrHPV infections and cervical lesions is higher among HIV(+) in comparison to HIV(-) women. Further studies should be performed providing an insight into a molecular mechanism responsible for this cooperation.

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Synchronicity of P53 Mutation and Multiple High-Risk HPV Genotypes, and the Risk of Cervical Cancer among Women in Osogbo, Nigeria

Oyenike

Akinbo

Adedokun

et al. 2022

Preprint

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Background: In low-and middle-income countries, high burden of cervical cancer is associated with human papillomavirus (HPV) due to poor screening and diagnostic methods at early stage. Reports showed that there are discrepancies in data correlating HPV-infection with development of cervical cancer while the functional roles of P53 oncogenic mutation are controversial. Furthermore, the molecular pathogenesis of multiple HPV-genotypes remains an open question. Thus, advancing investigations on HPV-associated cervical abnormalities would add to early diagnostic precision. Methods: Two hundred (n=200) cervical samples were collected from apparently healthy, active adult women following an ethical approval. Laboratory analyses were conducted through cytological assessment and histochemistry screening using the Papanicolaou smear. PCR methods were used to characterize HPV-DNA genotypes and P53 gene mutations. Positive cervical dysplasia cases were matched with HPV-DNA, and the HPV-genotypes were used to evaluate the prevalence of various HPV-subtypes and the risk of cervical cancer. Results: Twenty-four (n=24) cervical dysplasia and fifty-one (n=51) HPV+ were identified comprising single and multiple genotypes. While nine cases (n=9) showed p53 gene mutation with concurrent multiple high-risk HPV (hrHPV) genotypes, none of the single hrHPV genotypes had p53 mutation. More so, individuals with coexisting p53 mutation and multiple hrHPV-genotypes already manifesting cervical dysplasia were 22.2% of the group, while 77.8% had normal cervical architecture, the fate of whom was unknown during investigation. There was a higher cervical dysplasia among those with HPV oncogenes; there were connections between the HPV positivity with some genotypes (hrHPV16,18,31 and 33, respectively) and p53 mutation. Conclusion: P53 gene mutation was independent of HPV-associated cervical abnormalities in single hrHPV-genotype, though other mechanistic drivers attributed to p53 dysfunction by E6 and E7 remain plausible. On the other hand, infection with multiple hrHPVs showed a concomitant predominance with the P53 mutation, implying a potential interplay and an increased risk of cervical cancer.

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Human papillomavirus correlates of high grade cervical dysplasia among HIV-Infected women at a major treatment centre in Nigeria: a cross-sectional study

Cited by 10 publications

References 29 publications

Cervical Dysplasia, Infection, and Phylogeny of Human Papillomavirus in HIV-Infected and HIV-Uninfected Women at a Reproductive Health Clinic in Nairobi, Kenya

Cervical Dysplasia, Infection, and Phylogeny of Human Papillomavirus in HIV-Infected and HIV-Uninfected Women at a Reproductive Health Clinic in Nairobi, Kenya

Relationship between HPV and HIV. Prevalence, molecular mechanisms and screening of HPV among HIV infected women

Synchronicity of P53 Mutation and Multiple High-Risk HPV Genotypes, and the Risk of Cervical Cancer among Women in Osogbo, Nigeria

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