Human papillomavirus-associated digital squamous cell carcinoma: Literature review and report of 21 new cases

Alam, Murad; Caldwell, J. B.; Eliezri, Yehuda D.

doi:10.1067/mjd.2003.184

Cited by 135 publications

(175 citation statements)

References 59 publications

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“…A reasonable proportion of periungual SCC cases in the literature is associated with genital HPV infection, a few of those associated with cervical cancer, but mostly with genital warts or cervical dysplasia. 8 It is likely that our patient's anal cancer was attributable to HPV, developing before initiation of HAART. Compared with the general population, patients with one cancer attributable to HPV are at higher risk of developing a second HPV-related cancer.…”

Section: Discussionmentioning

confidence: 99%

“…7,8,18 Many of these modalities have been applied in our patient (as described above). As warts remained refractory to therapy and signs of invasive malignant transformation were observed, we finally decided to amputate the affected phalanges.…”

Section: Discussionmentioning

confidence: 99%

“…Remarkably, almost all reported digital SCCs that have been attributed to HPV were caused by HPV 16 or other species 9 or 11 alpha-papillomavirus. 8,10 To our knowledge there are two other reports of HPV 26 papillomavirus-associated digital SCC, which also occurred in HIV-positive patients. 18,19 In contrast to the case presented herein, in both previous patients only one finger was affected by an SCC.…”

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confidence: 99%

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Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy

Handisurya

Rieger

Bankier³

et al. 2007

Br J Dermatol

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SummarySquamous cell carcinoma (SCC) of the nail unit is a rare disorder. An association with high-risk genital human papillomavirus (HPV) infection has been reported. We report a 28-year-old human immunodeficiency virus (HIV)-infected bisexual man who had multiple invasive SCC of the fingers, infected with the rare type HPV 26. Classification of HPV 26 as high-or intermediate-risk type has been uncertain, due to its rare presence in cervical cancer. Despite successful treatment with highly active antiretroviral therapy (HAART), the patient developed extensive hyperkeratotic nailbed proliferations of all fingers. Tumours were refractory to treatment and invaded into adjacent tissues. X-rays of the hands demonstrated bone invasion, necessitating amputation of distal phalanges of several fingers. Histologically, highly differentiated preinvasive and invasive verrucous SCCs were identified. Molecular DNA typing identified HPV 26 in the SCCs and in some premalignant lesions. By in situ hybridization HPV 26 DNA was detected in numerous tumour cells, indicating productive infection with high-level amplification of the viral genome. In the remaining proliferations, high-risk HPV type 58, cutaneous HPVs and a putative new HPV type were identified. HPV 26 infection appears to be causally involved in the development of SCC of the nail unit in this immunosuppressed patient. Timely evaluation of chronic verrucous nailbed tumours is recommended, especially in immunocompromised patients. Identification of HPV 26, besides known high-risk HPV types, may identify patients at risk for developing SCC of the nailbed and possibly at other locations. especially on sun-exposed areas, whereas a possible role of HPV in keratinocyte (nonmelanoma) skin cancer of immunocompetent and immunosuppressed individuals is less clear. [4][5][6] SCC originating from the nail unit is rare, and misdiagnosis as onychomycosis or verruca vulgaris is quite common. SCC of the finger usually affects older age groups, and men more often than women. 7,8 An association with preceding radiation, chronic trauma or infection, immunosuppression, and exposure to hydrocarbons or arsenic has been reported. 8,9 Infection with high-risk HPV has been causally implicated in the pathogenesis of digital SCC, and the predominant type identified was HPV 16, suggesting that its high oncogenicity largely accounts for it being the main HPV type identified in most cases (similar to cervical cancer). KeywordsTo a lesser extent HPV 31, 33 (our unpublished observation), 34 and 35 have been identified, all closely related phylogenetically to HPV 16, as all are species 9 alphapapillomavirus 1,7 or species 11 alpha-papillomavirus. 10 Digital SCCs have been reported in patients with concomitant or antecedent genital HPV infection, and a proportion associated with cervical cancer, but most with genital warts or cervical dysplasia. The presence of the same HPV type in the digital and genital lesions has been identified. 8 Case reportA 28-year-old human immunodeficiency virus (HIV)-infect...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy

Handisurya

Rieger

Bankier³

et al. 2007

Br J Dermatol

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“…37,39 Detection of mucosal HPVs in lesions of SCC is frequent, and the most commonly identified is HPV 16. 40 The possible association of genital carcinomas and ungual SCC was documented in several studies, suggesting autoinoculation from genital lesions. 38 More rarely, other types of HPV are also found in lesions of ungual SCC, such as HPV 2, 31, 34, 35, 58, 61 and 73.…”

Section: Iii2basal and Squamous Cell Carcinomasmentioning

confidence: 99%

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

Leto¹,

Júnior²,

Porro

et al. 2011

An. Bras. Dermatol.

110

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Human papillomavirus (HPV) is a DNA virus that presents tropism for epithelial cells, causing infections of the skin and mucous membranes. Replication of HPV occurs in the nuclei of squamous cells and its life cycle is directly related to the differentiation program of the host cell. To date, nearly 100 different types of HPV have been characterized and there is a large number of other types that have not been sequenced yet. Besides being responsible for benign lesions of the skin and mucous membranes, HPV is also involved in the development of various mucocutaneous tumors: Bowen's disease, non-melanoma skin cancers and genital carcinomas. This review discusses the characteristics of HPV, malignant and benign mucous and skin manifestations caused by HPV, besides the main methods of detection and typing of the virus. Keywords: DNA Viruses; Papillomavirus Infections; Warts Resumo: O papilomavírus humano (HPV) é um vírus DNA que apresenta tropismo por células epiteliais, causando infecções na pele e nas mucosas. A replicação do HPV ocorre no núcleo das células escamosas e o seu ciclo de vida é diretamente relacionado ao programa de diferenciação da célula hospedeira. Até o momento, foram completamente caracterizados cerca de 100 tipos diferentes de HPVs e há um grande número adicional de tipos ainda não sequenciados. Além de ser o responsável por lesões benignas de pele e mucosas, o HPV também está envolvido no desenvolvimento de diversos tumores cutaneomucosos: doença de Bowen, cânceres de pele não melanoma e carcinomas genitais. Esta revisão aborda as características do HPV, quadros cutâneos e mucosos benignos e malignos causados por ele e os principais métodos empregados em sua detecção e tipagem.

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“…4,[13][14][15] É doença multifatorial e está relacionada principalmente com exposição à radiação ultravioleta B (UVB), queimaduras na infância, radiação ionizante, pele clara, genodermatoses, infecção por cepas oncogênicas do papiloma vírus humano (HPV), imunossupressão, agentes químicos e lesões cutâneas crôni-cas. 11,[14][15][16][17] As características clínicas e histológicas que estão associadas a maior risco de metástases e recidivas são indiferenciação histológica, invasão perineural, limites imprecisos do tumor, ulceração, recidiva e tamanho. 1,6,11,14,16,18 Há poucos artigos na literatura sobre CMM especificamente para o tratamento do CEC, e nenhum correlacionando fatores preditivos com maior número de está-dios cirúrgicos.…”

Section: Introductionunclassified

Fatores preditivos do maior número de estádios na cirurgia micrográfica de Mohs para o tratamento do carcinoma espinocelular da cabeça

Terzian

Neto

Pimentel

2008

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS -Os carcinomas espinocelulares da pele da cabeça têm como opção terapêutica mais segura a cirurgia micrográfica de Mohs, que apresenta os menores índices de recidiva e a máxima preservação tecidual. Características dos carcinomas espinocelulares podem estar relacionadas a maior número de estádios cirúrgicos. OBJETIVO -Definir características dos carcinomas espinocelulares que sejam preditoras de maior número de estádios na cirurgia de Mohs. MÉTODOS -Análise retrospectiva de 51 carcinomas espinocelulares da cabeça tratados pela cirurgia de Mohs para determinar fatores de risco de maior número de estádios. Foram analisados limites clínicos, morfologia, recidiva, histologia e tamanho, relacionando-os ao número de estádios cirúrgicos. A análise estatística foi realizada pelo teste exato de Fisher e regressão logística multivariada. RESULTADOS -Os carcinomas recidivados tiveram tendência a maior número de estádios (p=0,081). Os tumores com limites imprecisos apresentaram três vezes mais possibilidades de maior número de fases na análise da razão de chances. Esse achado foi compatível com dados da literatura, apesar de não ter sido estatisticamente significante. CONCLUSÃO -Características pré-operatórias dos carcinomas espinocelulares, como recidiva e limites imprecisos, apesar de não preditivas, indicaram tendência a maior número de estádios na cirurgia micrográfica de Mohs. Palavras-chave: Carcinoma de células escamosas; Cirurgia de Mohs; Diretrizes para a prática clínica; Neoplasias cutâneas; Neoplasias cutâneas/tratamento; Neoplasias de cabeça e pescoço Abstract: BACKGROUND -Squamous cell carcinomas of the skin of the head are better treated with

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Human papillomavirus-associated digital squamous cell carcinoma: Literature review and report of 21 new cases

Cited by 135 publications

References 59 publications

Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy

Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

Fatores preditivos do maior número de estádios na cirurgia micrográfica de Mohs para o tratamento do carcinoma espinocelular da cabeça

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