Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective

Aldalwg, Marwah Abbas Hassan; Brestovac, Brian

doi:10.1007/s12105-017-0780-7

Cited by 11 publications

(6 citation statements)

References 61 publications

(137 reference statements)

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“…Moreover, the HPV-16 type accounts for approximately 90% of HPV-positive oropharyngeal cancers (OPCs) [10,11]. Epidemiological data showed that the incidence of HPV-related head and neck cancer (HNC) is increasing [12][13][14][15]. HPV-associated head and neck cancers have different risk factors, clinical characteristics, and tumor biology when compared to tobacco/alcoholassociated head and neck cancers [16].…”

Section: Introductionmentioning

confidence: 99%

“…HPV-associated head and neck cancers are characterized by a younger age at onset, basaloid/warty histopathology, as well as superior survival outcomes when compared with their HPV-negative counterparts [18]. HPV-associated malignancies of the head and neck arise mainly in oropharyngeal sites, such as tonsils, the base of the tongue, and oropharynx; other oral sites, such as the ventrolateral tongue, gingivae, cheek, palate, and floor of the mouth are mainly attributed to tobacco use and alcohol consumption [15,19].…”

Section: Introductionmentioning

confidence: 99%

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Factors Associated with Attitudes towards Preventing Head and Neck Cancer through HPV Vaccination in Poland: A Nationwide Cross-Sectional Survey in 2021

2022

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Human papillomavirus (HPV) infection is a risk factor for head and neck cancers (HNC). HPV-related head and neck cancers are preventable through vaccination. This study aimed to assess the attitudes towards HPV vaccination among adults in Poland, with particular emphasis on preventing HPV-related HNC, as well as identifying factors associated with a willingness to vaccinate children against HPV. This cross-sectional survey was carried out in November 2021 on a nationwide, representative sample of 1082 adults in Poland. The computer-assisted web interview (CAWI) technique was used. Only 42.5% of respondents were aware that HPV infection is a sexually transmitted disease. Less than one fourth of respondents (23.8%) indicated vaccination as an HPV infection prevention method and 51.9% of respondents correctly indicated HPV vaccine-eligible populations. Only 48.1% of respondents declared positive attitudes towards HPV vaccinations and declared that they would vaccinate their child against HPV. Males (OR: 1.43, 95% CI: 1.11–1.85; p < 0.01), respondents who did not have children (OR: 1.50, 95% CI: 1.04–2.14; p < 0.05), as well as those who had received a higher education (OR: 1.43, 95% CI: 1.11–1.85; p < 0.01), had greater odds of indicating positive attitudes towards HPV vaccinations. This study revealed a low level of public awareness of HPV vaccination as a cancer prevention method in Poland.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors Associated with Attitudes towards Preventing Head and Neck Cancer through HPV Vaccination in Poland: A Nationwide Cross-Sectional Survey in 2021

2022

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“…Squamous Cell Carcinoma is the most commonly occurring cancer in oral cavity, which originates predominantly from buccal mucosa and tongue [1]. In Pakistan the burden of OSCC accounts for 10% of all cancers affecting both genders.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of Nibrin in Epithelial Dysplasia and OSCC: A Cross-Sectional Study

Abidi

Hosein

Butt

et al. 2021

JAMMR

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Inherited defect in DNA repair capability is the fundamental problem causing mutations to be passed on to new generation of cells leading to cancer. The NBS1/Nibrin/p95 belongs to the family of the DNA double-strand break repair complex (hMre11 complex) which is a transcript of the mutated NBS gene, located on human chromosome 8q21 The protein complex containing nibrin binds to the edges of the DNA double-stranded break causing defective repair process. Nibrin also activates various signaling cascades such as; phosphatidylinositide 3-kinases PI3-kinase/Akt triggering the oncogenic process. Aims: The purpose of this research was to aid in the diagnosis of oral cancer and dysplastic lesions in Karachi population. Study Design: This cross-sectional study was conducted at a tertiary care hospital. All samples were recruited for the study after obtaining written informed consent from patients and seeking ethical approval from Ethic Review Committee Ziauddin University (Reference Code: 0330618FAOM), Karachi Pakistan. Place and Duration of Study: Ziauddin hospital north Nazimabad Karachi, November 2018 to September 2019. Methodology: Expression of Nibrin (NBS1) was evaluated by Immunohistochemistry on dysplasia and OSCC biopsies by H-Score method. The tumor was graded by broder system. Immunohistochemical analysis for nibrin was performed on the tumor block. Mean, frequency, percentages were calculated for quantitative variables, chi square was used for qualitative variables. A value <0.05 was considered as significant. Results: 92% OSCC cases were positive for Nibrin while 80% of oral dysplasia revealed Nibrin expression. This accounts for significant statistical association of Nibrin with OSCC (0.012*) and dysplasia (0.001*). Unfortunately, apart from moderaterly histological differentiation (0.012) none of these clinicopathological parameters showed statistical significance. Conclusion: We conclude that a Nibrin protein showed overexpression among 92% of OSCC patients out of total 100 cases and in 80% out of 30 cases of dysplasia so the association of histological grading with expression of Nibrin was significant and expression of Nibrin intensity with histological grading was significant as well. Our study suggests that this expression of Nibrin may be used as a diagnostic marker for potential OSCC patients.

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“…HPV-related oropharyngeal SCC are still diagnosed at lesser rates than HPV-negative OSCC and the prevalence of high-risk HPV positivity in OSCC varies widely between developing countries [1]. In the HPV-negative subsets, chronic exposures to carcinogens and extensive consumption of alcohol have been largely associated with the induction of neoplasms [1,[15][16][17]. Oral leukoplakia and oral lichen planus are among the most frequent oral potentially malignant lesions and patients with those lesions are more susceptible to developing OSCC [18][19][20][21].…”

Section: Introduction Oral Squamous Cell Carcinomamentioning

confidence: 99%

The role of apical-basal polarity in oral cancer

Saintigny¹,

Bouaoud²,

Farrugia³

et al. 2020

J Transl Sci

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Over the last thirty years, improvements in survival rates of oral cancer patients have remained modest, hampered by the late diagnosis of the disease, a lack of understanding of the underlying biology of oral cancer, and a lack of identified actionable targets. While the apical-basal polarity has been widely investigated in normal and pathological contexts, its involvement in oral homeostasis is still not well understood. Here, we discuss the current documented role of PAR-3 complexdependent apical-basal polarity regulation in oral cancer. We explore molecular switches that link polarity dysfunction to oral cancer initiation and highlight relevant models that would promote our understanding of disease development for therapeutic interventions.Saintigny P (2019) The role of apical-basal polarity in oral cancer

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Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective

Cited by 11 publications

References 61 publications

Factors Associated with Attitudes towards Preventing Head and Neck Cancer through HPV Vaccination in Poland: A Nationwide Cross-Sectional Survey in 2021

Factors Associated with Attitudes towards Preventing Head and Neck Cancer through HPV Vaccination in Poland: A Nationwide Cross-Sectional Survey in 2021

Immunohistochemical Expression of Nibrin in Epithelial Dysplasia and OSCC: A Cross-Sectional Study

The role of apical-basal polarity in oral cancer

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