Human papillomavirus as an independent risk factor of invasive cervical and endometrial carcinomas in Jordan

Abu-Lubad, Mohammad; Jarajreh, Dua’a; Helaly, Ghada F.; Alzoubi, Hamed; Haddadin, Weliam J.; Dabobash, Mahmoud D.; Albataineh, Eman; Aqel, Amin A.; Alnawaiseh, Nedal

doi:10.1016/j.jiph.2019.08.017

Cited by 14 publications

(13 citation statements)

References 40 publications

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“…The involvement of HPV infection in the pathogenesis of endometrial carcinoma is controversial. A meta-analysis examining the prevalence of HPV DNA in tumor tissue from endometrial cancer revealed that the pooled prevalence of HPV DNA in endometrial cancer was 10.0% [230][231][232][233]. However, the HPV prevalence varied considerably from 0% to 54.5% [230].…”

Section: Uterine (Endometrial) Cancermentioning

confidence: 99%

Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins

Haręża

Wilczyński

Paradowska

2022

IJMS

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Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that only encodes a few proteins, and it is also responsible for 5% of all human cancers, including cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers. HPV types may be classified as high- and low-risk genotypes (HR-HPVs and LR-HPVs, respectively) according to their oncogenic potential. HR-HPV 16 and 18 are the most common types worldwide and are the primary types that are responsible for most HPV-related cancers. The activity of the viral E6 and E7 oncoproteins, which interfere with critical cell cycle points such as suppressive tumor protein p53 (p53) and retinoblastoma protein (pRB), is the major contributor to HPV-induced neoplastic initiation and progression of carcinogenesis. In addition, the E5 protein might also play a significant role in tumorigenesis. The role of HPV in the pathogenesis of gynecological cancers is still not fully understood, which indicates a wide spectrum of potential research areas. This review focuses on HPV biology, the distribution of HPVs in gynecological cancers, the properties of viral oncoproteins, and the molecular mechanisms of carcinogenesis.

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Section: Uterine (Endometrial) Cancermentioning

confidence: 99%

Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins

Haręża

Wilczyński

Paradowska

2022

IJMS

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“…Two Jordanian studies reported the presence of HPV infection in cervical cancer; they show an increase in the prevalence of HPV infection in Jordanian women with cervical cancer [101,102]. The first study reported an overall high-risk HPV prevalence in cervical cancer (87%), low-grade squamous intraepithelial lesions (72%), and high-grade squamous intraepithelial lesions (79%); genotyping identified HPV16 as the most predominant subtype (54%) in all cervical lesions [101].…”

Section: In Levant Countriesmentioning

confidence: 99%

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

et al. 2022

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The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered the leading cause of cervical cancer and other carcinomas of the anogenital tract. However, several studies reported their involvement in cancers of non-sexual regions, including colorectal, head and neck, and breast cancers. There are several studies from the Middle East and North Africa (MENA) regions on the potential association between high-risk HPVs and cancer; nevertheless, there are limited studies that address the significance of HPV vaccination as a potential guard against these cancers. In the current review, we present a comprehensive description of the current HPV-associated cancers prevalence rates in the MENA region, demonstrating their steady increase with time, especially in African regions. Moreover, we discuss the potential impact of vaccination against HPV infections and its outcome on human health in this region.

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“…Some research into risk factors involved in EC development and/or progression seems to be more a fishing expedition than a well thought-out approach. As an example, many serve findings showing that papillomavirus presence is an independent risk factor ( 34 ). As the study was performed in only one country, it has limited value.…”

Section: Risk Factorsmentioning

confidence: 99%

Endometrial cancer—is our knowledge changing?

Králíčková¹,

Větvička²,

Laganà³

2020

Transl Cancer Res TCR

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In developed countries, endometrial cancer (EC) is the most frequent gynecologic malignancy in postmenopausal women. At the same time, EC has become one of the most common cancers in numerous developing countries, probably influenced by global epidemic of obesity. The majority of patients have lowgrade endometrioid cancer with a high 5-year survival rate, but with high-risk EC, the survival rates are still rather low. However, despite intensive research in last decades, our knowledge of the mechanisms, risk factors, diagnosis and treatment have not significantly improved. The standard treatment of all types of EC is still a traditional combination of surgery, irradiation and/or chemotherapy, despite the fact that each of these options is not without having some negative side effects. Despite the fact that on the molecular level, EC is relatively well-studied, but the efforts to transform these findings into either diagnosis or therapies of EC remain elusive. In addition, some research into risk factors involved in the development or progression of EC seems to be more a fishing expedition than a well thought-out approach. The purpose of this review is to summarize the most recent developments in the search for biomarkers and prognostic markers and to discuss the progress in EC treatment.

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Human papillomavirus as an independent risk factor of invasive cervical and endometrial carcinomas in Jordan

Cited by 14 publications

References 40 publications

Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins

Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

Endometrial cancer—is our knowledge changing?

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