Human papillomavirus and p53 oncoprotein in verrucous carcinoma of the larynx

López-Amado, Manuel; García‐Caballero, Tomás; Lozano-Ramírez, Ascensión; Labella-Caballero, Torcuato

doi:10.1017/s0022215100134851

Cited by 35 publications

(19 citation statements)

References 19 publications

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“…4,5,17,22,27 Szentirmay et al concluded that epidemiologic and extensive laboratory evidence supports the association between HPV and a subset of cancers of the oral cavity, orapharynx, and larynx. 28 In addition, they pointed out that HPV-positive cancers of the head and neck region were more likely to have verrucous histological features.…”

Section: Discussionmentioning

confidence: 99%

“…5 In their study, three cases had both p53 oncoprotein and HPV antigen. 5 In the current study, all the HPVpositive cases were positive for p53.…”

Section: Fi Gu Re 2bmentioning

confidence: 93%

“…39 The coexpression of p53 and HPV in VC of the larynx has been previously demonstrated only in one study. 5 Lopez-Amado et al observed p53 expression in four of 10 tissue samples (40%). 5 In their study, three cases had both p53 oncoprotein and HPV antigen.…”

Section: Fi Gu Re 2bmentioning

confidence: 95%

“…5 Lopez-Amado et al observed p53 expression in four of 10 tissue samples (40%). 5 In their study, three cases had both p53 oncoprotein and HPV antigen. 5 In the current study, all the HPVpositive cases were positive for p53.…”

Section: Fi Gu Re 2bmentioning

confidence: 95%

“…4 Another important factor in the development of the carcinoma appears to be the presence of alterations in p53 gene activity. 5 p53 is an important tumor suppressor gene involved in the regulation of cell growth, DNA maintenance and apoptosis. In addiation, experimental evidence suggests that the p53 protein is related to cell aggressiveness and tumor metastasis.…”

Section: Investigation Of Hpv Infection and P53 Expression In Laryngealmentioning

confidence: 99%

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Investigation of HPV Infection and P53 Expression in Laryngeal Verrucous Carcinoma

Tunçbilek¹,

Çallı²,

Öncel³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Ver ru co us car ci no ma is an un com mon, well-dif fe ren ti a ted va ri ant of squ a mo us cell car ci no ma that is re gar ded as a low gra de, lo cally in va si ve ma lig nant tu mor with ra re po ten ti al for dis tant me tas ta sis. Alt ho ugh the pat ho ge ne sis of ver ru co us car ci no ma is unk nown, many pos sib le ca u ses ha ve been pro po sed. The le a ding the o ri es inc lu de hu man pa pil lo ma vi rus (HPV) in fec ti on and che mi cal car ci noge ne sis. The aim of this study is to analy se the sta tus of the p53 ge ne and hu man pa pil lo ma vi rus (HPV) in fec ti on in ver ru co us car ci no ma of larynx, and to in ves ti ga te the cor re la ti on of p53 ex pres si on and HPV in fec ti on in ver ru co us car ci no ma of the larynx. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : A ret ros pec ti ve study has be en per for med bet we en the ye ars of 1994 and 2004, com pri sing 21 con se cu ti ve pa ti ents with ver ru co us carci no ma of larynx. De ta i led cli ni cal pa ra me ters ha ve al so be en re vi e wed. HPV iden ti fi ca ti on was ac complis hed with poly me ra se cha in re ac ti on. p53 im mu no his toc he mistry was per for med on 21 ver ru co us car ci no ma using poly clo nal se rum CM-1. R Re e s su ul lt ts s: : The HPV in fec ti on has be en de tec ted in in all of the twenty-one ca ses of ver ru co us car ci no mas. p53 im mu no his toc he mistry was per for med on 21 HPV conta i ning ver ru co us car ci no mas and sho wed the ex pres si on of p53 in 14 ca ses. No sta tis ti cally sig ni fi cant dif fe ren ces we re fo und bet we en p53 ex pres si on and sta ge. C Co on nc c l lu u s si i o on n: : The da ta in di ca te that HPV and the in cre a sed ex pres si on of p53 can co e xist in ver ru co us car ci no mas. Our study sug gests that verrucous carcinomas of the larynx may ari se thro ugh a still unk nown mec ha nism which ca u ses p53 inac ti va ti on or HPV in fec ti on.We think that p53 ove rex pres si on and on co ge nic HPV in fec ti on may co o pe ra te in the estab lish ment of ma lig nant cells in ver ru co us car ci no ma of the larynx. The in te rac ti on bet we en the HPV in fec ti on and cer ta in cel lu lar on co ge nes such as p53 ne eds furt her studies.K Ke ey y W Wo or rd ds s: : Car ci no ma, ver ru co us; larynx; p53 pro te in, hu man; pa pil lo ma vi rus in fec ti ons Ö ÖZ ZE ET T A Am ma aç ç: : Na dir me tas taz po tan si ye li bu lu nan dü şük de re ce li lo kal in va ziv ma lign tü mör ola rak bi linen ver rü köz kar si nom, sku a möz hüc re li kar si no mun iyi di fe ran si ye bir var yan tı dır. Ver rü köz kar si nomun pa to ge ne zi bi lin me se de ba zı ola sı ne den ler öne sü rül müş tür. Bun la rın ba şın da hu man pa pil lo ma vi rus enfeksiyonu ve kim ya sal kar si no ge nez gel mek te dir. Ça lış ma mı zın ama cı la rink sin ver rü köz kar sinom la rın da p53 gen ve hu man pa pil lo ma vi rus en fek si yo nu nun ana li zi ve p53 eks pres yo nu ile hu man papil lo ...

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Section: Discussionmentioning

confidence: 99%

“…5 In their study, three cases had both p53 oncoprotein and HPV antigen. 5 In the current study, all the HPVpositive cases were positive for p53.…”

Section: Fi Gu Re 2bmentioning

confidence: 93%

Section: Fi Gu Re 2bmentioning

confidence: 95%

Section: Fi Gu Re 2bmentioning

confidence: 95%

Section: Investigation Of Hpv Infection and P53 Expression In Laryngealmentioning

confidence: 99%

See 3 more Smart Citations

Investigation of HPV Infection and P53 Expression in Laryngeal Verrucous Carcinoma

Tunçbilek¹,

Çallı²,

Öncel³

et al. 2010

Turkiye Klinikleri J Med Sci

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Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry

et al. 1999

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Recent evidence has shown that human papillomavirus (HPV) is involved in both the development of carcinoma and in premalignant mucosal lesions of the oral cavity. This study examined the relationship of HPV infection to some pathological features in precancerous lesions of the larynx, not examined extensively so far. Fifty formalin-fixed paraffin-embedded tissue sections containing human laryngeal precancerous lesions were screened for the presence of HPV infection by polymerase chain reaction, and for capsid protein expression by immunohistochemistry with polyclonal antibody directed against the L1 protein. The presence of HPV DNA was detected in 28 of 50 specimens (56%), including 9/12 cases with mild dysplasia (75%), 3/6 cases with moderate dysplasia (50%), and 7/11 cases with severe dysplasia (64%). Multiple HPV infections, containing two or three types, were detected in 17 of the 28 HPV-positive lesions (60%). Of 21 cases with keratosis and no dysplasia, 11 were positive for HPV DNA (52%) and 4 showed L1 staining (36%). By contrast, L1 positivity was revealed only in two lesions with moderate dysplasia, confirming that fully productive HPV infection is strictly dependent on epithelial differentiation and surface keratinization. The probability that HPV is a cofactor in the malignant progression of these lesions is suggested by the fact that 3/4 patients who developed cancer within 50 months were positive for HPV DNA.

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Human papillomavirus infections in laryngeal cancer

et al. 2011

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Although the association and clinical significance of human papillomavirus (HPV) infections with a subset of head and neck cancers, particularly for oropharyngeal carcinoma, has recently been well documented, the involvement of HPV in laryngeal cancer has been inadequately evaluated. Herein we review the currently known associations of HPV infections in diseases of the larynx and their potential for oncogenicity. Using several methods of detection, HPV DNA has been detected in benign (papillomatosis), indolent (verrucous carcinoma), and malignant (squamous cell carcinoma) lesions of the larynx. Consistent with the known oncogenic risk of HPV infections, common HPV types associated with laryngeal papillomatosis include low-risk HPV types 6 and 11, with high-risk HPV types 16 and 18 more commonly present in neoplastic lesions (verrucous carcinoma and squamous cell carcinoma). Although a broad range of prevalence has been noted in individual studies, approximately 25% of laryngeal squamous cell carcinomas harbor HPV infections on meta-analysis, with common involvement of high-risk HPV types 16 (highest frequency) and 18. Preliminary results suggest that these high-risk HPV infections seem to be biologically relevant in laryngeal carcinogenesis, manifested as having viral DNA integration in the cancer cell genome and increased expression of the p16 protein. Despite this knowledge, the clinical significance of these infections and the implications on disease prevention and treatment are unclear and require further investigation.

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Human papillomavirus and p53 oncoprotein in verrucous carcinoma of the larynx

Cited by 35 publications

References 19 publications

Investigation of HPV Infection and P53 Expression in Laryngeal Verrucous Carcinoma

Investigation of HPV Infection and P53 Expression in Laryngeal Verrucous Carcinoma

Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry

Human papillomavirus infections in laryngeal cancer

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