Human papillomavirus and cervical cancer: an insight highlighting pathogenesis and targeting strategies

Ojha, Prachi S.; Maste, Meenaxi M.; Tubachi, Siddarth; Patil, Vishal S.

doi:10.1007/s13337-022-00768-w

Cited by 13 publications

(10 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because p16 overexpression is closely linked to the disruption of cell cycle control by high-risk HPV types, it serves as a surrogate marker of HPV-associated oncogenic activity [48]. In the context of cervical cancer screening, the detection of associated oncogenic activity has been reported [49], and the detection of elevated p16 levels indicates an ongoing HPV infection that has altered the normal regulatory mechanisms of the cell cycle, suggesting the presence of potentially precancerous or cancerous changes in cervical epithelial cells [50].…”

Section: P16/ki-67 Dual Staining: An Emerging Tool For Triagementioning

confidence: 99%

Enhancing Cervical Cancer Screening: Review of p16/Ki-67 Dual Staining as a Promising Triage Strategy

Ouh,

Kim,

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Cervical cancer, primarily caused by high-risk human papillomavirus (HR-HPV) types 16 and 18, is a major global health concern. Persistent HR-HPV infection can progress from reversible precancerous lesions to invasive cervical cancer, which is driven by the oncogenic activity of human papillomavirus (HPV) genes, particularly E6 and E7. Traditional screening methods, including cytology and HPV testing, have limited sensitivity and specificity. This review explores the application of p16/Ki-67 dual-staining cytology for cervical cancer screening. This advanced immunocytochemical method allows for simultaneously detecting p16 and Ki-67 proteins within cervical epithelial cells, offering a more specific approach for triaging HPV-positive women. Dual staining and traditional methods are compared, demonstrating their high sensitivity and negative predictive value but low specificity. The increased sensitivity of dual staining results in higher detection rates of CIN2+ lesions, which is crucial for preventing cervical cancer progression. However, its low specificity may lead to increased false-positive results and unnecessary biopsies. The implications of integrating dual staining into contemporary screening strategies, particularly considering the evolving landscape of HPV vaccination and changes in HPV genotype prevalence, are also discussed. New guidelines and further research are necessary to elucidate the long-term effects of integrating dual staining into screening protocols.

show abstract

Section: P16/ki-67 Dual Staining: An Emerging Tool For Triagementioning

confidence: 99%

Enhancing Cervical Cancer Screening: Review of p16/Ki-67 Dual Staining as a Promising Triage Strategy

Ouh,

Kim,

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Particularly crucial in the etiopathogenesis of CC is the integration of DNA HPV with the human genome. The HPV proteins participate in the development of chronic inflammation, which is an important etiopathogenetic factor of CC [ 104 , 105 , 106 , 107 ]. Genetic studies have allowed the identification of changes in signaling pathways such as TGFβ and PI3K/MAPK.…”

Section: Role Of Mirnas In Cervical Cancermentioning

confidence: 99%

MicroRNAs as Potential Biomarkers in Gynecological Cancers

2023

View full text Add to dashboard Cite

MicroRNAs are non-coding transcripts that, thanks to the ability to regulate the mRNA of target genes, can affect the expression of genes encoding tumor suppressors and oncogenes. They can control many important cellular processes, including apoptosis, differentiation, growth, division, and metabolism. Therefore, miRNAs play an important role in the development of many cancers, including gynecological cancers. Ovarian cancer, endometrial cancer, cervical cancer, and vulvar cancer are the most common cancers in women and are a frequent cause of death. The heterogeneity of the pathogenesis of these gynecological diseases makes the diagnostic process a significant obstacle for modern medicine. To date, many studies have been carried out, in which particular attention has been paid to the molecular pathomechanism of these diseases, with particular emphasis on miRNAs. To date, the changed profile of many miRNAs, which influenced the promotion of proliferation, migration, invasion processes and the simultaneous inhibition of programmed cell death, has been proven many times. Detailed understanding of the molecular effects of miRNAs in the above-mentioned gynecological cancers will enable the development of potential predictive and prognostic biomarkers, as well as the optimization of the diagnostic process.

show abstract

“…HPV, a double-stranded closed-circle DNA virus, has a propensity to infiltrate the basal layer cells of squamous epithelium as well as the cells in the transformation zone. HPV can be classified into two types: high-risk and low-risk [ 18 , 19 ]. High-risk HPV is inclined to infect the basal cells in the cervical tissue and the proliferative cells in the transformation zone, ultimately leading to carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…High-risk HPV is inclined to infect the basal cells in the cervical tissue and the proliferative cells in the transformation zone, ultimately leading to carcinogenesis. Among these types, HPV-16 and HPV-18 demonstrate the most potent infectivity and the closest correlation with cervical lesions [ 19 ]. Approximately 80% of women have experienced HPV infection at some point in their lives; however, the majority of these infections are transient, as around 90% of infected individuals are capable of spontaneously clearing the virus within 1 to 2 years.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Integration of Data Regarding the Correlation of TNF-α rs1800629 Polymorphism with Susceptibility to Cervical Cancer

Marzbanrad,

Karimi-Zarchi,

Noei-Teymoordash

et al. 2024

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: Cervical cancer, globally, ranks as the runner-up among the most prevalent forms of cancer affecting women. The role of the tumor necrosis factor alpha (TNF-α) polymorphism in the susceptibility to cervical cancer has been a subject of interest. However, the current evidence regarding this association remains inconclusive. Methods: To address this uncertainty, eligible studies were systematically searched and retrieved from various databases including Cochrane Library, EMBASE, PubMed, Web of Science, CNKI, and Wanfang database. The search was conducted until September 01, 2023. The collected literature was then subjected to independent analysis by two authors. The pooled odds ratio along with the corresponding 95% confidence interval was calculated using different genetic models. Additionally, sensitivity and cumulative analyses were performed to assess the stability of the obtained results. Results: A total of 29 case-control studies involving 8850 cases and 9286 controls were included in the present analysis. The findings revealed that the TNF-α rs1800629 polymorphism increased the risk of cervical cancer under the allele genetic model (A vs. G: OR = 1.277, 95% CI = 1.104-1.477, P = 0.001) in the general population. Subgroup analysis based on ethnicity demonstrated that this polymorphism was associated with an increased risk of cervical cancer in Caucasian and African women, but not in Asians. Furthermore, subgroup analysis based on country of origin indicated a significant correlation between the TNF-α rs1800629 polymorphism and an increased risk of cervical cancer in American and Chinese women, but not in Iranian women. Conclusions: The findings from this meta-analysis suggest that the TNF-α rs1800629 polymorphism is a risk factor for cervical cancer in the general population, particularly in Caucasian and African women. However, further well-designed studies are warranted to validate these findings.

show abstract

Human papillomavirus and cervical cancer: an insight highlighting pathogenesis and targeting strategies

Cited by 13 publications

References 170 publications

Enhancing Cervical Cancer Screening: Review of p16/Ki-67 Dual Staining as a Promising Triage Strategy

Enhancing Cervical Cancer Screening: Review of p16/Ki-67 Dual Staining as a Promising Triage Strategy

MicroRNAs as Potential Biomarkers in Gynecological Cancers

A Comprehensive Integration of Data Regarding the Correlation of TNF-α rs1800629 Polymorphism with Susceptibility to Cervical Cancer

Contact Info

Product

Resources

About