Human papillomavirus‐31‐related types predict better survival in cervical carcinoma

Huang, Lee-Wen; Chao, Shiouh-Lirng; Hwang, Jiann-Loung

doi:10.1002/cncr.20003

Cited by 36 publications

(32 citation statements)

References 40 publications

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“…The conclusion that virtually all cervical cancer were HPV positive 1 has not been confirmed in later studies. Taking into account the overall population of 2,717 patients corresponding to recent reports [22][23][24][25][26][27][28] and this study, the global rate of HPV negative invasive carcinoma is 10.1%, ranging from 2% 26 to 26.1%. 24 Several reasons may be evoked to account for potential false negativity of viral analysis (rare or not yet cloned HPV, loss of viral DNA sequences during the tumour process, lack of methodology.…”

Section: Discussionmentioning

confidence: 74%

“…Moreover, controversial data have been reported concerning the prognostic value of the HPV genotype associated with invasive carcinoma. A favourable outcome of tumours associated with HPV31 7 or HPV58 8 and an unfavourable outcome of tumours associated with HPV31 7,8 and a unfavourable outcome of tumours associated with HPV18 were reported, [9][10][11][12] whereas no significant association was observed in other studies. 13,14 In this context we have performed a virological and clinical retrospective study with a long-term follow up in order to (i) define the HPV types found in a large series of invasive carcinoma in France and (ii) assess the prognostic value of the different HPV types.…”

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confidence: 85%

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Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

Crémoux

Rochefordière

Savignoni

et al. 2008

Intl Journal of Cancer

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Human papillomavirus (HPV) DNA sequences are associated with the large majority of invasive cervical carcinoma but the role of specific genotype(s) in the outcome of the disease is still debated. To determine the viral epidemiology in the French population of patients and the prognostic value of HPV genotypes in cervical cancer, we performed a retrospective study in 515 patients treated in our Institution from 1985 to 2005. Ninety-six percent of the cases were found associated with HPV DNA whereas 4% remained HPV negative. High-risk HPV 16/18 genotypes were found in 70% of the cases. HPV 18 was more frequently associated with adenocarcinoma (40.6%) than HPV 16 (10.4%) and found in tumours developed in younger women (mean age, 45.8 years) than HPV 16 (48.3 years) or other HPV types (53.6 years). In multivariate analysis, node involvement (p < 0.0001), parametria invasion (p 5 0.009), tumour size (p 5 0.01) and HPV status (p 5 0.02) were associated with disease-free survival (median follow-up 95 months). Disease outcome was better in tumours associated with intermediate risk HPV types (HPV 31,33,35,39, 52, 53, 58, 59, 73) than in tumours with high oncogenic types (HPV 16, 18, 45) (p 5 0.03). Node status and tumour size remained prognostic factor for overall survival. Our data show that HPV genotype is one of the biological factors associated with the outcome of cervical cancer. One third of invasive carcinoma were not associated with HPV 16/18, indicating that the screening for cervical neoplasia should be maintained after prophylactic vaccination against these HPV genotypes. ' 2008 Wiley-Liss, Inc.Key words: cervical cancer; HPV; prognosis Human papillomavirus (HPV) DNA sequences are associated with most of invasive cervical carcinoma worldwide 1 and the role of HPV as a causative agent of cervical neoplasia is well documented. 2 There is a large plurality of HPV types since more than 100 different genotypes have been identified 3 among which more than 40 infect ano-genital mucosa. Histological and virological analyses have shown that 3 groups of genital HPV could be identified according to their oncogenic properties. Low-risk HPVs (HPV6,11,42,43, 44. . .), present in low grade cervical intraepithelial neoplasia (CIN) but rare in invasive cancer, intermediaterisk HPVs (HPV 31,33,35, 51, 52, 58. . .), more prevalent in CIN than in invasive cancer, and high-risk HPVs (HPV16, 18, 45, 56. . .), more frequently found in invasive carcinoma than in CIN. 4 Experimental data have disclosed that high-risk E6 and E7 oncoprotein act in the tumour process by interfering with cell cycle G1-S checkpoint. 5 Virological epidemiology data show that HPV16 and HPV18 are the most prevalent genotypes found in invasive carcinoma worldwide but that there are significant geographic variations in the prevalence of less common genotypes. 6 In the perspective of prophylactic vaccination, it is thus necessary to accurately determine the prevalence of the different HPV types in cervical cancer at country level. Moreover, controversial data...

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Section: Discussionmentioning

confidence: 74%

mentioning

confidence: 85%

Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

Crémoux

Rochefordière

Savignoni

et al. 2008

Intl Journal of Cancer

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“…27 Other reports reveal that HPV 16, 18 and 45 are substantially found more often in an integrated state compared with HPV 31 and 33 and that precancerous states induced by HPV 16,18 and 45 progress to invasive cervical cancer in less time compared with those induced by HPV 31 and 33. 28 This is consistent with the current results, which reveal that levels of oncogenic expression of HPV 16, 18, 52 and 58 have been increasing with the degree of cervical dysplasia and progression to cervical cancer but not for HPV 31 and 33.…”

Section: Discussionmentioning

confidence: 99%

“…Early Detection and Diagnosis assay, 27 whereas another used a 2-step assay separating the RT step from the PCR and measuring the amount of RNA transcript in exactly 20 ng of total cDNA. 23 This assay differs from others in 2 ways.…”

Section: Discussionmentioning

confidence: 99%

Type‐specific human papillomavirus oncogene messenger RNA levels correlate with the severity of cervical neoplasia

Lee²,

Chang

et al. 2010

Intl Journal of Cancer

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This study aimed to evaluate whether quantitation of high-risk human papillomavirus (HR-HPV) E6 messenger RNA (mRNA) can be a potential biomarker for detecting the severity of cervical lesions. HPV genotyping was performed using a modified MY11/ GP61 PCR for HPV DNA amplification, followed by HPV genotype-specific hybridization with on a gene chip. E6 type-specific PCR was used to validate multiple infections. Quantitative real-time reverse transcriptase (QRT-PCR) and real-time PCR used to measure mRNA levels and DNA viral loads of 6 HPV oncogenic types (HPV 16,18,31,33, 52 and 58) in 720 liquid-based cytology samples. The HPV DNA and RNA measurements were correlated with cervical lesions diagnosed by histopathologic examination. mRNA transcripts in the 6 types HPV DNA-positive cases was lower in normal women and

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“…Although etiology of CC is related to HPV infection, the prognostic role of different genotypes, if any, is not clear. Several authors did not find any correlation between HPV genotypes and survival (Tong, 2007;Cuschieri, 2014;Lau, 2015), while others found intermediate risk HPV correlating with better outcome than high risk genotypes (de Cremoux, 2009;Huang, 2004). Indeed, controversial results involve also the two most frequent high risk genotypes.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

Berois

Nozar

Greif

et al. 2017

MRAJ

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Although the causal role of Human papillomavirus (HPV) Relating to HPV, three prognostic groups were observed. The better clinical outcome was related to genotypes other than HPV16/18/45, while HPV16/18 genotypes belong to an intermediate risk group and the worse prognosis was related to HPV negative and HPV45. HPV independent tumors have been suggested as a different entity compared with virally driven ones. Improvement in knowledge of molecular pathogenesis could impact in CC patients care. In conclusion, worse prognosis was related to HPV negative and HPV45 related tumors. More research is warranted for better understanding molecular basis of virally driven or independent cervical cancer oncogenesis.

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Human papillomavirus‐31‐related types predict better survival in cervical carcinoma

Abstract: The presence of HPV-31-related types was an independent predictor of better survival in patients with cervical carcinoma. Therefore, HPV genotyping of cervical carcinomas may have profound implications for future patient management.

Cited by 36 publications

References 40 publications

Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

Type‐specific human papillomavirus oncogene messenger RNA levels correlate with the severity of cervical neoplasia

Prevalence and Distribution of High-Risk Human Papillomavirus Genotypes in Invasive Carcinoma of the Uterine Cervix in Uruguay. An update on clinical outcome

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