Human papilloma virus lesions of the oral cavity: healing and relapse after treatment with 810–980 nm diode laser

Angiero, Francesca; Buccianti, Alberto; Parma, Luisa; Crippa, Rolando

doi:10.1007/s10103-013-1401-7

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…Apart from the surgical scalpel, the use of lasers has also been proposed to eliminate these lesions 11–13 . Thus, photocoagulation might induce denaturation of viral proteins, killing the virus concomitant with the complete removal of the papilloma 14 . However, there is no consensus in the literature, since there are authors that show a high papilloma recurrence rate in groups treated with lasers.…”

Section: Discussionmentioning

confidence: 99%

Treatment of papillomatous lesions in a patient with Goltz syndrome—A case report

et al. 2022

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Background Goltz syndrome, also known as focal dermal hypoplasia (FDH), is a rare genetic disorder that affects ectodermal and mesodermal tissues. The purpose of this study is to report the treatment of papillomatous lesions in the orofacial region of a patient with Goltz syndrome. Case description A 31‐year‐old male patient was attended at Dental School of Federal University of Goiás with the chief complaint of discomfort during speaking and eating, due to the presence of a papillomatous lesion at the labial commissure. During the physical examination, syndrome characteristics were found, such as unilateral anophthalmia; atrophic cutaneous lesions of different intensities of pigmentation, mostly on the arms and neck; sparse hair; ectrodactyly, being the right hand was shaped like a ‘lobster claw’; and body asymmetry. In addition, papillomatous lesions at the right labial commissure and on the dorsum of the tongue were noted, which were subsequently removed with surgical laser. The microscopic diagnosis of the lesions was a squamous papilloma. Conclusion The proposed surgical treatment was well succeeded, and the rarity of the present case also having Goltz syndrome is an uncommon condition in males.

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Section: Discussionmentioning

confidence: 99%

Treatment of papillomatous lesions in a patient with Goltz syndrome—A case report

et al. 2022

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“…In 2015, Angiero et al reported the absence of complications and only one recurrence (with the lesion disappearing after a second application) in treating 174 lesions in 170 immunocompromised patients. In the larger sample size studies, the authors reported excellent patient tolerance and a short duration of surgical sessions [28][29][30]. Interestingly, a split-mouth study conducted by Beder et al in 2012 of 10 lesions in 5 patients treated with both CO 2 lasers and electrocautery reported that the viral load three weeks after surgery was significantly lower or absent in laser-treated areas [29].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Recurrence of Oral HPV-Related Lesions: Systematic Review of the Literature and Meta-Analysis

et al. 2021

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(1) Background The incidence of oral cavity lesions related to human papillomavirus (HPV) is 3%. There are no reliable data in the literature on recurrence rates of HPV-related oral cavity lesions. The only data available concern gynecological infections, which have a recurrence rate of ~30%. Recurrence may be due to a failure to completely eradicate the lesion, persistence of the viral infection, or persistence of an immune-compromised state. Therefore, the study aimed to ascertain the most effective therapeutic strategy to achieve complete eradication of the virus and avoid a possible recurrence of lesions, based upon the long-term behavior of the virus with the type of treatment. (2) Methods: Systematic searches of the Cochrane Library, EMBASE, Pubmed, Web of Science, clinicaltrials.gov, and SCOPUS were performed. Restrictions were placed on the date of publication and language. Only English or Italian language articles published between Jan 1990 and Dec 2019 were included in the meta-analysis. The following keywords and/or corresponding medical subject heading terms were used: “oral papillomavirus lesions” and “oral HPV lesions” or “treatment”, “therapy”, “therapeutics,” and “management”. (3) Results: Upon systematic literature review of all analyzed HPV-lesion treatment techniques, 36 studies on laser and cold scalpel eradications were selected. These studies document an excellent success rate from excisional treatments using both laser and cold scalpel and report low recurrence rates with both techniques, respectively 5.98% and 4.07%. (4) Conclusions: The meta-analysis revealed that additional studies with greater sample sizes are needed for these two treatment methods. It would also be appropriate to carry out case-controlled studies, preferably RCTs, to determine the best treatment for eradicating HPV-related lesions.

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“…The use of a diode laser instead of the traditional biopsy method has some advantages which are as follows: less bleeding during the procedure, allowing for a clearer surgical field; better tolerance of post-surgical pain; and a faster recovery time (complete healing in the first 30 days post-surgery). 12 Additional advantages are that hemostasis allows for a second intention healing process. The possibility of avoiding sutures, especially in the palate, can help to extend the surgical margins beyond those strictly needed.…”

Section: Discussionmentioning

confidence: 99%

Recurrent p16-Positive Human Papillomavirus (HPV) Associated Oral Lesions Treated with a Diode Laser: A Case Report Oral Lesions Treated with a Diode Laser: A Case Report

Pezzi¹,

Passerini²,

Frontera³

et al. 2019

J Dent Indones

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Human papillomavirus (HPV) family comprises approximately 150 known subtypes of viruses that can infect humans and other animals. Among these, HPV-16 has been shown to be associated with oral squamous cell carcinoma, particularly within the oropharynx. Here we describe the case of a patient with recurrent p-16 positive papillomatous lesions, which were successfully treated via a diode laser (445 nm) surgery. Radical treatment of HPV-related lesions can be difficult to achieve. Notably, some viruses may infect multiple oral sites and spread throughout the whole mucosa. Even after the supposed radical intervention, HPV particle remnants may lead to recurrences and new lesions. A new laser approach allows radical surgery to be performed, providing an effective method for the treatment of widespread lesions, similar to those reported here. Objective: To report a recurrent p-16 positive oral papillomatous lesion treated with a diode laser. Case report: A 26-year-old man with multiple p-16 positive oral papillomatous lesions was referred for recurrences after treatment with conventional surgery (cold knife). The lesions were successfully treated via diode laser (445 nm) surgery with no recurrence observed during the 6-month follow up. Histological examination showed immunohistochemical positivity for p16.Conclusions: Radical surgical treatment of HPV-related lesions is important to prevent recurrence and malignant transformation. Laser surgery represents an innovative treatment option.

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Human papilloma virus lesions of the oral cavity: healing and relapse after treatment with 810–980 nm diode laser

Cited by 9 publications

References 20 publications

Treatment of papillomatous lesions in a patient with Goltz syndrome—A case report

Treatment of papillomatous lesions in a patient with Goltz syndrome—A case report

Prevention of Recurrence of Oral HPV-Related Lesions: Systematic Review of the Literature and Meta-Analysis

Recurrent p16-Positive Human Papillomavirus (HPV) Associated Oral Lesions Treated with a Diode Laser: A Case Report Oral Lesions Treated with a Diode Laser: A Case Report

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