Human papilloma virus in head and neck squamous cell cancer.

Kermani, Iraj Asvadi; Seifi, Safoura; Kermani, Atabak Asvadi; Dolatkhah, Roya; Sakhinia, Ebrahim; Lotfi, Alireza; Mohammadi, Ghodrat; Naderpour, N.; Hajipour, Sara; Dastgiri, Saeed; Esmaili, Habibollah; Ebrahimi, Ardalan; Haggi, A. Asghari

doi:10.1200/jco.2011.29.15_suppl.e16011

Cited by 4 publications

(7 citation statements)

References 24 publications

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“…On the other hand, it seems that age has a noticeable direct effect on the prevalence of HPV positive HNSCCs. For example, in East Azerbaijan, Halimi and Morshedi (18) reported a prevalence rate of 20% with the mean age of 68.9 years, while Kermani et al (19) found a prevalence rate of 57.1% with the mean age of 39.7 years. Similarly, in Tehran, Haratian et al (20) reported a prevalence rate of 62.5% with the mean age of 44.37 years, while Seraj et al (21) found a prevalence rate of 26.6% with the mean age of 57.88 years, and Karbalaie Niya et al (22) reported a prevalence of as low as 3.2% with the mean age of 60.5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Studying the HPV positivity in our study showed that HPV was present in only three patients (all male), which equals to 6.5% of the study population. Previous studies on the prevalence of HPV between patients with head and neck, oral cavity, and oropharyngeal SCC in Iran have reported highly variable values, i.e., 21.6–60% in Southwest ( 16 , 17 ), 14% in South ( 14 ), and 20–57.1% in Northeast ( 18 , 19 ). Even in Tehran, the recorded prevalence rates (3.2–62.5%) have followed this variable trend ( 20 – 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…HPV16 is believed to be the most prevalent HPV genotype in HNSCC worldwide ( 22 ). It was frequently detected in Iranian studies followed by HPV18 ( 19 , 20 , 22 ). In our study, there was found no HPV16 genotype, but two patients were carriers of HPV18.…”

Section: Discussionmentioning

confidence: 99%

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The Frequency of Human Papillomavirus Positivity in Iranian Patients with Head and Neck Squamous Cell Carcinoma

et al. 2021

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Background & Objective: Human papillomavirus (HPV) has been associated with prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Similar to the global studies, different prevalence rates of this viral infection have been reported in Iran. Therefore, we aimed to report the prevalence of this virus and its significance in HNSCC patients. Methods: Patients who were referred to the five hospitals of Tehran city from May 2018 to May 2019 were enrolled in this study. All patients were diagnosed with HNSCC based on pathologic study. The pathologic disease staging was defined, and DNAs were extracted from the fresh tissue samples via kits. After polymerase chain reaction (PCR), HPV positive samples were evaluated for determining genotypes and data analysis. Results: Of the 46 patients, three patients (6.5%) showed positive HPV results with the following subtypes: 18 (in two patients), 52 (in three patients), 61 (in two patients), 67, and 73. Comparison of variables between the groups with and without HPV showed a significant difference based on the tumor’s lymphatic invasion ( P =0.041), peripheral lymph node involvement ( P =0.008), and histologic grade ( P =0.011), but no statistically significant difference in terms of other variables such as age, primary tumor site, size, pathologic stage, vascular or perineural invasion, metastasis, smoking, and alcohol consumption was found.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Frequency of Human Papillomavirus Positivity in Iranian Patients with Head and Neck Squamous Cell Carcinoma

et al. 2021

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“…Twenty-seven studies reported the prevalence of HPV based on the classification of lesions. 12,13,19,20,26,29,[38][39][40][41][42][43][44][45][46][47][49][50][51][52][53][54][55][56][57][58][59] The results of the meta-analysis showed that the prevalence of HPV was as follows: the prevalence in normal mucosa was 8% with a confidence interval of 0.04-0.15; the prevalence in reactive lesions was 22% with a confidence interval of 0.5-0.60; the prevalence in precancerous lesions was 29% with a confidence interval of 0.17-0.44; the prevalence in malignant lesions was 18% with a confidence interval of 0.13-0.24.…”

Section: Results Of Meta-analysismentioning

confidence: 99%

Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran: A systematic review and meta‐analysis

Aghaeipour

Salehiniya

Abbaszadeh

2021

Journal of Medical Virology

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The role of human papillomavirus (HPV) in the development of oral lesions is controversial. There has been no comprehensive study about HPV prevalence in Iran. This systematic review and meta-analysis were aimed at finding HPV prevalence of oral lesions and normal oral mucosa in Iran. International (PubMed, Web of Science, and Scopus) and national (Iranmedex, Irandoc, and SID) databases were searched systematically until October 2020. Studies that examined the prevalence of HPV in oral lesions by polymerase chain reaction method were included. The heterogeneity of articles was assessed with the Cochran test and I-Square statistics.The prevalence rate of HPV was calculated using a random-effect model. Of 3729 initially searched articles, 29 articles were eligible for inclusion. The overall prevalence of HPV in oral lesions was 21%. The prevalence was the highest in Rasht (50%) city. Lip lesions had the highest HPV prevalence (40%). According to the classification of lesions, the highest prevalence was of precancerous lesions (29%) and the lowest in normal mucosa (8%). Well-differentiated tumors showed a higher prevalence than poorly-differentiated ones. The highest prevalence of HPV was hairy leukoplakia (70%) and the lowest was of pyogenic granuloma (6%). Also, the prevalence was 31% in oral squamous cell carcinoma. There are differences between HPV prevalence according to the geographical area, intraoral location, type of lesion, and grading. As HPV prevalence was fairly high, further attention to vaccination and treatment for HPV in Iran, as a potential risk factor for oral precancerous and cancerous lesions is recommended.

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“…There are about 30 different types of HPV viruses that have been linked to benign and malignant epithelial lesions 9 . Furthermore, high-risk HPV strains such as HPV-16 and HPV-18 are thought to be etiologic factors for HNSCC 10,11 . The presence of HPV-16 in exfoliated oral epithelial cells may raise the risk of HNSCC and oropharyngeal cancer by 4 and 14 times, respectively 12 .…”

Section: Introductionmentioning

confidence: 99%

Lineage and phylogenetic analysis of HPV-16, -18 in saliva of HNSCC patients

et al. 2022

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Aim: Head and Neck Squamous Cell Carcinoma (HNSCC) is a global health problem whose incidence varies by geographic region and race according to risk factors. Human papillomavirus (HPV) infection is a significant risk factor for HNSCC. HPV-16 and HPV-18 are two forms of HPV that are carcinogenic. HNSCCs that are HPV positive have a better prognosis rather than HPV negative. The purpose of this research was to characterize HPV-16, -18 variations in the saliva of HNSCC patients by examining the genetic diversity of HPV-16, -18 utilizing the full E6, E7, and L1 genes. Methods: The case-control research included 15 patients with HNSCC and 15 healthy volunteers. Unstimulated entire saliva samples were obtained from the case and control groups by spitting method. Genomic DNA was isolated from all saliva samples. A PCR reaction was used to determine the presence of HPV in saliva. HPV-positive samples were genotyped and data were analyzed. We conducted a variant study on the HPV-16, -18 E6, and E7 genes. Results: Three patients with HNSCC were HPVpositive for two HPV genotypes out of 30 people diagnosed with HPV-DNA. HPV-16 and -18 were the most common genotypes. The HPV-16, -18 E6, and E7 genes were sequenced and compared to the HPV-16, -18 (E6, E7) prototype sequence. In all, HPV-16 lineages A1 and HPV-18 lineages A3 were discovered. Conclusion: Regarding the variation of HPV found in Iranian HNSCC patients, the need for further studies in HPV genotyping was seen. Sequencing HPV genes in HNSCC may help answer questions about HPV genotyping in the Iranian population. HPV genotype analysis aids in the development of vaccinations against HNSCC, halting disease progression and preventing HPV-associated HNSCC.

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Human papilloma virus in head and neck squamous cell cancer.

Cited by 4 publications

References 24 publications

The Frequency of Human Papillomavirus Positivity in Iranian Patients with Head and Neck Squamous Cell Carcinoma

The Frequency of Human Papillomavirus Positivity in Iranian Patients with Head and Neck Squamous Cell Carcinoma

Prevalence of human papillomavirus (HPV) in oral mucosal lesions in Iran: A systematic review and meta‐analysis

Lineage and phylogenetic analysis of HPV-16, -18 in saliva of HNSCC patients

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