Human papilloma virus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis

Gorgoulis, Vassilis G.; Zacharatos, Panayotis; Kotsinas, A.; Kyroudi, A.; Rassidakis, A N; Ikonomopoulos, John; Barbatis, Calypso; Herrington, C. Simon; Kittas, Christos

doi:10.1016/s0046-8177(99)90005-9

Cited by 83 publications

(89 citation statements)

References 52 publications

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“…Nonetheless, malignant transformation of lesions caused by HPV 11 does occur, although it is an infrequent occurrence (15,16). DNA sequence analysis has shown that specific viral mutations are associated with malignant transformation, demonstrating the role of specific viral genes in oncogenesis (17).…”

Section: Discussionmentioning

confidence: 99%

“…It has also been reported in adult-onset papillomatosis that HPV is more frequently detected in laryngeal carcinomas than in dysplastic, noninvasive laryngeal papillomas, suggesting that HPV plays a later role in carcinogenesis in adultonset cases than in juvenile-onset cases (15). HPV typing was performed in two cases of malignant transformation of adult-onset laryngeal papillomatosis.…”

Section: Discussionmentioning

confidence: 99%

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Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

et al. 2000

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Squamous papillomas of the lung are an uncommon feature of recurrent respiratory papillomatosis, occurring in fewer than 1% of cases. We describe a 23-year-old patient with pulmonary papillomas who developed a fatal squamous cell carcinoma of the lung. PCR-based human papillomavirus (HPV) typing showed the presence of HPV 11 DNA in both benign papillomas and invasive carcinoma. A review of the literature reveals four reports of malignant transformation of juvenile-onset recurrent respiratory papillomatosis in which HPV typing was performed. Similar clinical features are noted in all of the reports; specifically, each case has arisen in a young adult man with a history of papillomatosis since childhood. In each of the cases, HPV 11 was identified in association with the squamous cell carcinoma. Although HPV 11 is uncommonly associated with the development of invasive carcinoma at other sites, these findings suggest that it is correlated with malignant transformation in the setting of juvenile-onset recurrent respiratory papillomatosis. KEY WORDS: Human papillomavirus 11, Recurrent respiratory papillomatosis, Squamous cell carcinoma. Mod Pathol 2000;13(8):914-918Juvenile-onset recurrent respiratory papillomatosis (RRP) is characterized by numerous squamous papillomas of the respiratory tract secondary to infection with human papillomavirus (HPV) types 6 and 11 (1, 2). HPV is thought to be acquired at the time of vaginal delivery in the presence of genital lesions, and patients typically present with symptoms of hoarseness or respiratory obstruction in childhood or adolescence. In the majority of cases, the papillomas are confined to the larynx; only 5% of patients exhibit more distal involvement of the trachea, and involvement of lung parenchyma occurs in fewer than 1% of cases (1, 2). Pulmonary involvement by RRP is twice as frequent in males than in females and is associated with an aggressive clinical course. Most patients require numerous excisions, frequently require tracheostomy, and ultimately die as a result of respiratory insufficiency or infections (2). Malignant transformation of laryngeal or pulmonary lesions is a very rare event in the absence of prior irradiation; fewer than 20 cases are reported in the English literature (3-6). It remains unclear whether the risk of malignant transformation is dependent on the HPV serotype involved.We describe a patient with pulmonary involvement by RRP who developed a squamous cell carcinoma of the lung. Polymerase chain reaction (PCR) typing performed at postmortem examination showed the presence of HPV 11 DNA in both the papillomas and squamous cell carcinoma. This is the fifth report of an association between HPV 11 and malignant transformation of pulmonary papillomas (3, 4, 6, 7). Together, these five cases suggest a stereotypical clinical setting for the emergence of invasive carcinoma from RRP. CASE REPORTThe patient was a 23-year-old white man with a history of RRP, initially diagnosed at age 5. By age 10, he had developed laryngeal, tracheal, and pulmonary ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

et al. 2000

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“…To avoid false-negative results due to low DNA yield or low number of viral copies, extracted DNA integrity was confirmed by amplifying a 523-bp fragment of p53 exons 5-6, which is larger than the HPV fragments obtained by the PCR (9). In the first step of the NPCR assay, we used the degenerate L1 consensus primers MY09 and MY11 (47), which provide a sensitivity comparable to that of Southern blotting (1 viral copy per 10 2 cells) (48).…”

Section: Methodsmentioning

confidence: 99%

“…Some of these types, such as 16, 18, 33, and 58, seem to play a role in the development of certain human tumors and are characterized as "high risk" types (7). Squamous cell malignant lesions of the cervix are infected mainly by high-risk viral types (8), whereas other organs, such as the larynx, are infected by a wide range of HPV types with varying tumorigenic potential (7,9).…”

Section: Abstract: Human Papillomavirus Oral Carcinoma Oral Dysplamentioning

confidence: 99%

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“High Risk” HPV Types Are Frequently Detected in Potentially Malignant and Malignant Oral Lesions, But Not in Normal Oral Mucosa

et al. 2000

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Studies on the involvement of the human papillomavirus (HPV) in initiation and progression of oral neoplasia have generated conflicting results. The observed discrepancy is attributable mainly to the varying sensitivity of the applied methodologies and to epidemiologic factors of the examined patient groups. To evaluate the role of HPV in oral carcinogenesis, we analyzed 53 potentially neoplastic and neoplastic oral lesions consisting of 29 cases of hyperplasia, 5 cases of dysplasia, and 19 cases of squamous cell carcinomas, as well as 16 oral specimens derived from healthy individuals. A highly sensitive nested polymerase chain reaction (PCR) assay was used, along with type-specific PCR, restriction fragment length polymorphism analysis, dot blotting, and nonisotopic in situ hybridization. Nested PCR revealed the presence of HPV DNA in 48 of the 53 (91%) pathologic samples analyzed, whereas none (0%) of the normal specimens was found to be infected. Positivity for HPV was independent of histology and the smoking habits of the analyzed group of patients. At least one "high risk" type, such as HPV 16, 18, and 33, was detected by type-specific PCR in 47 (98%) infected specimens, whereas only 1 (2%) squamous cell carcinoma was solely infected by a "low risk" type (HPV 6). HPV 16 was the prevailing viral type, being present in 71% of infected cases. Single HPV 16 and HPV 18 infections were confirmed by restriction fragment length polymorphism. HPV 58 was detected by dot blotting in three hyperplastic lesions. HPV positivity and genotyping were further confirmed, and the physical status of this virus was evaluated by nonisotopic in situ hybridization. Diffuse and punctate signals, indicative of the episomal and integrative pattern of HPV infection, were observed for low-and high-risk types, respectively. Our findings are suggestive of an early involvement of high-risk HPV types in oral carcinogenesis.

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Human papillomavirus infections in laryngeal cancer

et al. 2011

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Although the association and clinical significance of human papillomavirus (HPV) infections with a subset of head and neck cancers, particularly for oropharyngeal carcinoma, has recently been well documented, the involvement of HPV in laryngeal cancer has been inadequately evaluated. Herein we review the currently known associations of HPV infections in diseases of the larynx and their potential for oncogenicity. Using several methods of detection, HPV DNA has been detected in benign (papillomatosis), indolent (verrucous carcinoma), and malignant (squamous cell carcinoma) lesions of the larynx. Consistent with the known oncogenic risk of HPV infections, common HPV types associated with laryngeal papillomatosis include low-risk HPV types 6 and 11, with high-risk HPV types 16 and 18 more commonly present in neoplastic lesions (verrucous carcinoma and squamous cell carcinoma). Although a broad range of prevalence has been noted in individual studies, approximately 25% of laryngeal squamous cell carcinomas harbor HPV infections on meta-analysis, with common involvement of high-risk HPV types 16 (highest frequency) and 18. Preliminary results suggest that these high-risk HPV infections seem to be biologically relevant in laryngeal carcinogenesis, manifested as having viral DNA integration in the cancer cell genome and increased expression of the p16 protein. Despite this knowledge, the clinical significance of these infections and the implications on disease prevention and treatment are unclear and require further investigation.

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Human papilloma virus (HPV) is possibly involved in laryngeal but not in lung carcinogenesis

Cited by 83 publications

References 52 publications

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

“High Risk” HPV Types Are Frequently Detected in Potentially Malignant and Malignant Oral Lesions, But Not in Normal Oral Mucosa

Human papillomavirus infections in laryngeal cancer

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