Human Papilloma Virus (HPV) and the Current State of Oropharyngeal Cancer Prevention and Treatment

Gribb, Jacob P.; Wheelock, John H.; Park, Etern S.

doi:10.32481/djph.2023.04.008

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Therefore, adopting a vigilant approach to sexual practices becomes a crucial recommendation [ 18 ]. We also need to deal with the new, emerging evidence that in developed countries, OSCC has become the most frequent HPV-related cancer, surpassing cervical cancer [ 19 ]. Furthermore, it is predicted that by 2030, most squamous cell carcinomas will be HPV-related rather than the non-HPV-related form [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Dellino,

Pinto,

D’Amato

et al. 2024

JCM

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Human genital papilloma virus infection is the most prevalent sexually transmitted infection in the world. It is estimated that more than 75% of sexually active women contract this infection in their lifetime. In 80% of young women, there is the clearance of the virus within 18–24 months. In developed countries, oral squamous cell carcinoma (OSCC) is now the most frequent human papilloma virus (HPV)-related cancer, having surpassed cervical cancer, and it is predicted that by 2030 most squamous cell carcinomas will be the HPV-related rather than non-HPV-related form. However, there are currently no screening programs for oral cavity infection. While the natural history of HPV infection in the cervix is well known, in the oropharynx, it is not entirely clear. Furthermore, the prevalence of HPV in the oropharynx is unknown. Published studies have found wide-ranging prevalence estimates of 2.6% to 50%. There are also conflicting results regarding the percentage of women presenting the same type of HPV at two mucosal sites, ranging from 0 to 60%. Additionally, the question arises as to whether oral infection can develop from genital HPV infection, through oral and genital contact or by self-inoculation, or whether it should be considered an independent event. However, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. Therefore, this literature review aims to evaluate whether there is evidence of a connection between oral and cervical HPV, while also endorsing the usefulness of the screening of oral infection in patients with high-risk cervical HPV as a means of facilitating the diagnosis and early management of HPV-related oral lesions. Finally, this review emphasizes the recommendation for the use of the HPV vaccines in primary prevention in the male and female population as the most effective means of successfully counteracting the increasing incidence of OSCC to date.

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Section: Introductionmentioning

confidence: 99%

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Dellino,

Pinto,

D’Amato

et al. 2024

JCM

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“…Globally, at least eleven percent of cancer cases are due to virus infection 1–5 . DNA viruses, such as EBV, Human Papillomaviruses (HPV), and HBV, are some of the most commonly associated with cancer and are frequently reported to be integrated into the human genome.…”

Section: Introductionmentioning

confidence: 99%

Microhomology‐mediated repair machinery and its relationship with HPV‐mediated oncogenesis

Chatterjee,

Starrett

2024

Journal of Medical Virology

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Human Papillomaviruses (HPV) are a diverse family of non‐enveloped dsDNA viruses that infect the skin and mucosal epithelia. Persistent HPV infections can lead to cancer frequently involving integration of the virus into the host genome, leading to sustained oncogene expression and loss of capsid and genome maintenance proteins. Microhomology‐mediated double‐strand break repair, a DNA double‐stranded breaks repair pathway present in many organisms, was initially thought to be a backup but it's now seen as vital, especially in homologous recombination‐deficient contexts. Increasing evidence has identified microhomology (MH) near HPV integration junctions, suggesting MH‐mediated repair pathways drive integration. In this comprehensive review, we present a detailed summary of both the mechanisms underlying MH‐mediated repair and the evidence for its involvement in HPV integration in cancer. Lastly, we highlight the involvement of these processes in the integration of other DNA viruses and the broader implications on virus lifecycles and host innate immune response.

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“…1 Despite the development of successful prophylactic vaccines, the incidence of HPVassociated cancers continues to rise. 2 During HPV infection, the HPV E6 and E7 viral oncoproteins disrupt the activity of cellular tumor suppressor proteins leading to tumorigenesis. 3 The tumor-specific expression of these oncoproteins provides several antigenic targets for immunotherapeutic treatments.…”

mentioning

confidence: 99%

“…Persistent infection with high-risk HPV is the leading cause of several cancers affecting more than 45,000 new patients annually in the US alone . Despite the development of successful prophylactic vaccines, the incidence of HPV-associated cancers continues to rise . During HPV infection, the HPV E6 and E7 viral oncoproteins disrupt the activity of cellular tumor suppressor proteins leading to tumorigenesis .…”

mentioning

confidence: 99%

DNA Anchoring Strength Directly Correlates with Spherical Nucleic Acid–Based HPV E7 Cancer Vaccine Potency

Hwang,

Dittmar,

Kang

et al. 2024

Nano Lett.

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Human Papilloma Virus (HPV) and the Current State of Oropharyngeal Cancer Prevention and Treatment

Cited by 7 publications

References 10 publications

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature

Microhomology‐mediated repair machinery and its relationship with HPV‐mediated oncogenesis

DNA Anchoring Strength Directly Correlates with Spherical Nucleic Acid–Based HPV E7 Cancer Vaccine Potency

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