Human papilloma virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in Taiwan

Abstract

This study does not support an association between oncogenic HPV and the carcinogenesis or prognosis of WHO-II/III NPCs in Taiwan.

Epstein‐Barr virus and human papillomaviruses as favorable prognostic factors in nasopharyngeal carcinoma: A nationwide study in Finland

“…13,25,[27][28][29] Only a few studies have assessed the association of HPV status and disease outcome, and mostly they have not found statistically significant differences in survival between patients with HPV-positive and HPV-negative tumors. 13,20,[27][28][29] In our study, HPV was detected in 14% of all cases. We used a HPV E6/E7 mRNA ISH method, 37 detecting transcriptionally active high-risk HPV mRNA, which has not been used in NPC studies before.…”

“…12 Studies from both endemic and nonendemic regions have reported the occurrence of HPV in NPC tumors, with or without the coexistence of EBV. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Unlike in oropharyngeal carcinoma, 32 no statistical significance for outcome has been attributed to HPV in NPC with 1 exception: Dogan et al reported that patients with HPV-positive tumor had, similarly to the patients with EBVpositive tumor, significantly better overall survival (OS) than the patients with EBV/HPV-negative tumor. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] In addition, Jiang et al suggested that although overexpression of p16 is not a significant prognostic marker for OS in NPC, it correlates with better progression-free survival and locoregional control in patients with EBV-positive tumor.…”

Human papillomavirus 16 detected in nasopharyngeal carcinomas in white Americans but not in endemic Southern Chinese patients

“…Given the improved overall survival of patients with HPV-related oropharyngeal squamous cell carcinoma, it raises the question of whether patients with HPV(+) tumors in the nasopharynx will also have better overall survival than those with EBV(−)/HPV(−) tumors. In a study of 46 Taiwanese patients with NPC, 35% of whom had HPV(+) tumors, Huang et al 18 found no correlation of HPV status with survival.…”

“…Some studies have shown an association with cigarette smoking or environmental exposures (eg, formaldehyde and wood dust), 11,15,16 whereas others have suggested non-EBV viral causes, including human papillomavirus (HPV). [10][11][12][13][17][18][19][20][21][22] Hïrding et al 17 was the first to identify HPV-11 and HPV-16 DNA in NPC tumors by PCR. Since then, several studies have suggested that certain types of NPC tumors may harbor the HPV virus.…”

Nasopharyngeal carcinoma: A review

“…It should be noted that although EBVnegative NPCs were more likely to be HPV positive, the majority of the EBV-negative cases were also HPV negative. In yet another relatively recent study, 226 43 Taiwanese NPC cases (1 K and 42 NK; 43 cases EBV positive) were assessed. By PCR, HPV DNA was identified in 13/42 (31%) of NK cases.…”