Human papilloma virus: An etiological and prognostic factor for oral cancer?

Lafaurie, Gloria Inés; Perdomo, Sandra J.; Buenahora, María Rosa; Amaya, Sandra; Díaz‐Báez, David

doi:10.1111/jicd.12313

Cited by 20 publications

(14 citation statements)

References 120 publications

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“…Some rare functional SNPs may have an influence on survival. Finally, the human papilloma virus (HPV) status and inflammatory cytokines expression of patients was not included in the analysis and may limit the interpretation of our findings; hence, HPV and cytokines may affect survival [37,38]. However, a major strength of our study is that all the patients had a similar tumor stage and received the same treatment.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in ERCC5 rs17655 and ERCC1 rs735482 Genes Associated with the Survival of Male Patients with Postoperative Oral Squamous Cell Carcinoma Treated with Adjuvant Concurrent Chemoradiotherapy

Senghore

Chien

Wang

et al. 2019

JCM

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The nucleotide excision repair (NER) pathway plays a major role in the repair of DNA damaged by exogenous agents, such as chemotherapeutic and radiotherapeutic agents. Thus, we investigated the association between key potentially functional single nucleotide polymorphisms (SNPs) in the NER pathway and clinical outcomes in oral squamous cell carcinoma (OSCC) patients treated with concurrent chemoradiotherapy (CCRT). Thirteen SNPs in five key NER genes were genotyped in 319 male OSCC patients using iPLEX MassARRAY. Cox proportional hazards models and Kaplan–Meier survival curves were used to estimate the risk of death or recurrence. Carriers of the XPC rs2228000 TT genotype showed a borderline significant increased risk of poor overall survival under the recessive model (hazard ratio (HR) = 1.81, 95% confidence interval (CI) = 0.99–3.29). The CC genotypes of ERCC5 rs17655 (HR = 1.54, 95% CI = 1.03–2.29) and ERCC1 rs735482 (HR = 1.65, 95% CI = 1.06–2.58) were associated with an increased risk of worse disease-free survival under the recessive model. In addition, participants carrying both the CC genotypes of ERCC5 rs17655 and ERCC1 rs735482 exhibited an enhanced susceptibility for recurrence (HR = 2.60, 95% CI = 1.11–6.09). However, no statistically significant interaction was observed between them. Our findings reveal that the ERCC5 rs17655 CC and ERCC1 rs735482 CC genotypes were associated with an increased risk of recurrence in male patients with OSCC treated with CCRT. Therefore, CCRT may not be beneficial, and alternative treatments are required for such patients.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms in ERCC5 rs17655 and ERCC1 rs735482 Genes Associated with the Survival of Male Patients with Postoperative Oral Squamous Cell Carcinoma Treated with Adjuvant Concurrent Chemoradiotherapy

Senghore

Chien

Wang

et al. 2019

JCM

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“…HPV is one of the major causes of viral sexually transmitted infections (STIs) and has been suggested as a potential risk factor for development of genitourinary cancers [7]. The etiologic role of high risk types of HPV (16 and 18) in development of different cancers has been suggested previously [8][9][10][11]. Currently, there are several studies that described a correlation between HPV and development of bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

Association of human papilloma virus (HPV) infection with oncological outcomes in urothelial bladder cancer

Moghadam

Mansori

Nowroozi

et al. 2020

Infect Agents Cancer

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Background: Bladder cancer is one of the leading causes of cancer death in adults worldwide. There are various risk factors described for the bladder cancer development including genetic background as well as environmental exposure. Currently, infectious agents such as human papilloma virus (HPV) has also been linked to bladder cancer risk. The current study aimed to evaluate the potential correlation between HPV infection and the oncological outcome in urothelial bladder cancer. Methods: Totally 106 tissue samples of histopathologically confirmed transitional cell carcinoma (TCC) of the urinary bladder were included in this study. The presence of high risk (types 16 and 18) and low risk (types 11 and 6) types of HPV was evaluated using polymerase chain reaction (PCR) followed by in situ hybridization. Results: Out of 106 bladder cancer patients, a total of 24 cases (22.6%) were positive HPV infection. The most common type of HPV detected was type 16 followed by types 11 and 18, and 6. According to independent T-test results, there was a significant association between mean age and HPV infection (P = 0.015). Moreover, our findings showed a significant relation between infection with HPV and tumor stage, tumor grade, muscle invasion of the tumor, as well as tumor recurrence. The results of Chi-square Test indicated that there is significant statistical association between types of HPV and tumor grade (P-Value = 0.044). Conclusion: Our findings indicated that a family history of cancer and HPV infection can be potential independent predictive factors for tumor recurrence in bladder cancer. Overall, the results of this study strongly indicate a significant relationship between HPV infection and an aggravated outcome of the disease and a higher risk of recurrence in patients with bladder cancer.

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“…Большинство ВПЧ-положительных форм рака головы и шеи связано с ВПЧ 16 и 18 типов [44]. Эти два типа также присутствуют в большинстве злокачественных новообразований аногенитальных органов и шейки матки [45], что можно частично объяснить изменениями в сексуальном поведении в последние десятилетия. Фактически двадцать первый век стал свидетелем снижения возраста начала половой жизни, увеличения числа партнеров, практикующих оральный секс [46], а также свободным доступом к сайтам онлайн-знакомств [47].…”

Section: вирус эпштейна-баррunclassified

Risk Factors for the Development of Malignant Tumors of the Head and Neck

Belyakova¹

2021

Epidemiology and Vaccinal Prevention

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Relevance. Recently, there has been an increase in the incidence of head and neck cancer throughout. Head and neck cancer is one of the most common forms of cancer, accounting for 5-10% of all cancers in the world. In the structure of cancer it takes 8th place. Aim. Highlight the main risk factors for the development of malignant neoplasms of the head and the etiological role of the human papillomavirus. Conclusions. Currently, it is an increase in prevalence of viral infections is considered to be the main cause of increase in the incidence of squamous cell carcinoma of the head and neck, and this pathology is more common among non-smoking middleaged man with a high socio-economic status, having oral-genital sex with multiple sexual partners, as well as having poor dental status.

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Human papilloma virus: An etiological and prognostic factor for oral cancer?

Cited by 20 publications

References 120 publications

Polymorphisms in ERCC5 rs17655 and ERCC1 rs735482 Genes Associated with the Survival of Male Patients with Postoperative Oral Squamous Cell Carcinoma Treated with Adjuvant Concurrent Chemoradiotherapy

Polymorphisms in ERCC5 rs17655 and ERCC1 rs735482 Genes Associated with the Survival of Male Patients with Postoperative Oral Squamous Cell Carcinoma Treated with Adjuvant Concurrent Chemoradiotherapy

Association of human papilloma virus (HPV) infection with oncological outcomes in urothelial bladder cancer

Risk Factors for the Development of Malignant Tumors of the Head and Neck

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