Human Palatal and Tuberosity Mucosa as Donor Sites for Ridge Augmentation

Dellavia, Claudia; Ricci, Giano; Pettinari, Letizia; Allievi, Cristina; Grizzi, Fabio; Gagliano, Nicoletta

doi:10.11607/prd.1929

Cited by 34 publications

(80 citation statements)

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“…Therefore, it can be summarized that tCTG and SCTG illustrate not only different percentages of lamina propria and submucosa, but also gene expression that may explain the variability in clinical outcomes (KT width gain, volume gain, and hyperplastic healing). In particular, tCTG resembles a more a fibrotic tissue with a tendency for a hyperplastic response and, therefore, as suggested by Dellavia et al., its thickness should be limited to <3 mm.…”

Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 91%

Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 99%

“…The reason for the different clinical performance between the SCTG and tCTG has also been investigated in histologic studies and at the molecular level . Compared to the SCTG, the tCTG was found to have a denser but less vascularized lamina propria (72.79% for the tCTG vs. 51.08% for the SCTG) whereas the SCTG showed to be richer in submucosal tissue including glandular and adipose components (25.75% vs. 4.89%) . Given the evidence suggesting that high amounts of submucosa tissue in the graft may result in more graft shrinkage, less volume gain, and no or minimal effect on epithelium keratinization induction, these findings further support the rational to consider tCTG as a viable (or of higher quality) alternative to palatal CTG, especially when comparing to grafts harvested from the deep palate …”

Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 99%

“…On a molecular level, a tendency for decrease in mRNA levels of collagen type I and III (COL‐I and COL‐III) was observed in tCTG compared to SCTG and the overall long lysyl hydroxylase 2 (LH2b) mRNA levels was upregulated . In addition, a four‐fold increase in LH2b/COL‐1 ratio has been reported in tCTG, suggesting that tuberosity‐derived collagen is less subject to degradation by metalloproteinases . This may be the mechanism responsible for collagen accumulation in sites augmented with tCTG.…”

Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 99%

See 3 more Smart Citations

Is a soft tissue graft harvested from the maxillary tuberosity the approach of choice in an isolated site?

Tavelli

Barootchi

Greenwell

et al. 2019

Journal of Periodontology

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Soft tissue augmentation procedures are becoming more popular these days. Different soft tissue graft harvesting approaches have been proposed. Nonetheless, the location of the donor site (whether anterior‐, lateral‐, superficial‐, deep‐palate or the maxillary tuberosity) can affect the graft shape and its composition. Soft tissue grafts from the maxillary tuberosity are rich in connective tissue fibers, with minimal presence of fatty or glandular components. Clinical, histological, and molecular evidence shows that a soft tissue graft obtained from the maxillary tuberosity has unique properties. In addition, harvesting from this area presents minimal risk for intra‐ or postoperative complications, leading to reduced patient morbidity. The aim of this commentary is to discuss the advantages and disadvantages of harvesting a soft tissue graft from the tuberosity and to compare it with the traditional palatal graft, while highlighting functional, esthetic, and patient‐related outcomes.

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Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 91%

Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 99%

Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 99%

Section: Histologic and Molecular Analysis Of Tuberosity Soft Tissue mentioning

confidence: 99%

See 2 more Smart Citations

Is a soft tissue graft harvested from the maxillary tuberosity the approach of choice in an isolated site?

Tavelli

Barootchi

Greenwell

et al. 2019

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

“…Maxillary tuberosity has been used as a donor site in addition to the palate in recent years. The connective tissue grafted from the tuberosity is stable in the first few months, but hyperplastic reaction and unesthetic white tissue patch appearance are often observed [76,77].…”

Section: Soft Tissue Augmentation In Implant Therapymentioning

confidence: 99%

Strategies for alveolar ridge reconstruction and preservation for implant therapy

Masaki

Nakamoto

Mukaibo

et al. 2015

Journal of Prosthodontic Research

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Hyperplastic Response Following Soft Tissue Augmentation in the Esthetic Zone

Gluckman¹,

Toit

Pontes³

et al. 2018

Clin Adv Periodontics

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Introduction The indications for augmentation of gingival tissue by connective tissue graft (CTG) are numerous. The techniques are widely adopted with extensive literature reporting high success. Harvest techniques include the mid to anterior palate, versus the posterior palate and tuberosity. The latter comprises denser collagen, identified as a more suitable graft. Alas, rarely have hyperplastic responses been reported. Case Presentation Two adult, Caucasian patients presented with clinical need for soft tissue augmentation. Autogenous tissue was opted for, harvesting from the tuberosity gingiva. De‐epithelialized outside the mouth and inserted into envelope flaps, late healing resulted in hyperplastic gingival lesions. Neither lesion could be successfully removed, and biopsy for histopathological investigation was carried out. Conclusion Hyperplastic response resulting from soft tissue augmentation with tuberosity CTG is rare but may occur. Laser or scalpel might not ensure complete removal. Informing the patient of this rare adverse effect may be important.

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Human Palatal and Tuberosity Mucosa as Donor Sites for Ridge Augmentation

Cited by 34 publications

References 0 publications

Is a soft tissue graft harvested from the maxillary tuberosity the approach of choice in an isolated site?

Is a soft tissue graft harvested from the maxillary tuberosity the approach of choice in an isolated site?

Strategies for alveolar ridge reconstruction and preservation for implant therapy

Hyperplastic Response Following Soft Tissue Augmentation in the Esthetic Zone

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