Human Orf

Johannessen, Jan Vincents; Krugh, Hans-Kristian; Solberg, Ingvar; Dalen, Are; Wijngaarden, H. Van; Johansen, B.V.

doi:10.1111/j.1600-0560.1975.tb00179.x

Cited by 73 publications

(78 citation statements)

References 13 publications

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“…A search of the scientific literature using the terms orf or contagious pustular dermatitis and erythema multiforme or hypersensitivity found 10 case reports [10][11][12][13][14][15][16][17][18] and about 30 instances of EM identified in epidemiological [4,[19][20][21] and immunological [22] studies of human orf infections. Among patients receiving a diagnosis of orf, an estimated 7-18% experience EM [19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme after orf virus infection: a report of two cases and literature review

et al. 2014

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SUMMARYOrf virus has a worldwide distribution among sheep and goats. The hypersensitivity reaction erythema multiforme (EM) is a known complication of orf infection in humans; however, its occurrence is poorly understood and has not been extensively reviewed. We present two unrelated cases of orf-associated EM, and a review of the literature, highlighting important clinical, epidemiological and immunological aspects of this condition. Orf and its associated complications can occur in rural areas, as well as urban settings, where it is less well-known, through religious or cultural practices involving animal slaughter. Obtaining a history of animal exposures from patients with lesions suspicious for orf and secondary skin eruptions can guide diagnosis and identification of the inciting immune stimulus. Determining the pathophysiology and relative contribution of host and viral factors contributing to EM and other orf-associated hypersensitivity reactions could facilitate the identification of risk factors and inform treatment decisions.

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Section: Discussionmentioning

confidence: 99%

Erythema multiforme after orf virus infection: a report of two cases and literature review

et al. 2014

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“…Only one case series reported isolation of typical bacterial pathogens from Orf lesions (10). These pathogens were isolated in only nine of 119 cases (10). There are no reports in the literature of Orf itself causing extensive local edematous reactions in humans.…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial superinfection is also considered to be an uncommon complication. Only one case series reported isolation of typical bacterial pathogens from Orf lesions (10). These pathogens were isolated in only nine of 119 cases (10).…”

Section: Discussionmentioning

confidence: 99%