Human oral retention of zinc from mouthwashes containing zinc salts and its relevance to dental plaque control

Harrap, G. J.; Best, J.S.; Saxton, C. A.

doi:10.1016/0003-9969(84)90110-9

Cited by 50 publications

(49 citation statements)

References 17 publications

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“…Previous data indicated that zinc ions may inhibit both the adsorption of bacteria to the tooth surface [Skjorland et al, 1978] and the growth of existing plaque bacteria [Harrap et al, 1984;Saxton et al, 1986], Possibly, inhibition occurs to a certain level irrespective of the basic ability to form sucrose-in duced plaque. On the other hand, existing variations in the susceptibility to zinc may reflect variations in the bacterial composition of the dental plaque flora.…”

Section: Discussionmentioning

confidence: 99%

“…The plaque-inhibiting effect of zinc probably also depends on retention of the ions to receptors in dental plaque and in the oral cavity, followed by a subse quent sustained release from these retention sites [Afseth, 1983;Afseth et al, 1983a, b;Harrap et al, 1984], The long-lasting retention of zinc in dental plaque ra ther than the rapid release of zinc into saliva may be of importance to its plaque-inhibiting effect [Afseth, 1983;Afseth et al, 1983a;Harrap et al, 1984]. Zinc ions may be bound to similar receptors as chlorhexidine [Waler and Rolla, 1980].…”

Section: Discussionmentioning

confidence: 99%

“…Zinc ions may be bound to similar receptors as chlorhexidine [Waler and Rolla, 1980]. The oral mucosa may thus be an important reservoir for zinc ions [Waler and Rolla, 1980;Harrap et al, 1984].…”

Section: Discussionmentioning

confidence: 99%

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Dose-Related Effects of ZnCl₂on Dental Plaque Formation and Plaque Acidogenicity in vivo

Giertsen¹,

Scheie²,

Rölla³

1989

Caries Res

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The plaque-inhibiting capacity of 5-, 10-, 20-, and 100-mM ZnCl₂ solutions was examined in 10 dental hygienist students. Twice daily mouthrinses with a 10-ml solution of 5, 10, and 20 mM ZnCl₂ significantly inhibited plaque formation (p ≤ 0.05), whereas 100 mM ZnCl₂ had only a negligible effect. Mouthrinses with 5 and 100 mM ZnCl₂ were also tested in 6 dental students characterized as being heavy plaque formers. In this group, the antiplaque effect of 5 mMZnΔ¾ was more pronounced, while 100 mM ZnCl₂ also significantly decreased plaque accumulation. The effect of a single mouthrinse with a 10-ml solution of 5 and 100 mMZnCl₂on plaque acidogenicity was also assessed in 5 dental students. 5 mM ZnCl₂ significantly depressed acid production by plaque 30 min after a rinse, while 100 mM ZnCl₂ inhibited acid production significantly for up to 4 h. 100 mM ZnCl₂ was significantly more effective at depressing acid production than 5 mM ZnCl₂ 30 min after a rinse.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dose-Related Effects of ZnCl₂on Dental Plaque Formation and Plaque Acidogenicity in vivo

Giertsen¹,

Scheie²,

Rölla³

1989

Caries Res

View full text Add to dashboard Cite

show abstract

“…As a consequence, zinc has drawn a considerable interest for dental implant as it exhibits similar antimicrobial activity than silver without any esthetic side effects [9][10][11] . In addition, it has been shown that Zn 2+ ion is a good inhibitor of human dental plaque 12) . However, and similarly to silver, adverse effects on the healthy tissue can be generated from Zn 2+ ion with a mild cytotoxicity at concentration above 10 −4 mol/L 13) .…”

Section: Introductionmentioning

confidence: 99%

Preparation of Antibacterial ZnO-CaO-P2O5-Nb2O5 Invert Glasses

et al. 2016

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ZnO-CaO-P 2 O 5 -Nb 2 O 5 invert glasses, with ZnO substituted for CaO, were successfully prepared using a melt-quenching method. Their structures, dissolution behaviors, and antibacterial abilities were evaluated. Niobate switched its role of network former to modi er with increasing ZnO content, as Zn 2+ ions preferentially coordinated with phosphate groups. In parallel, with increasing content of ZnO in the glasses, P-O-Zn bonds were formed, which crosslinked phosphate groups with ZnO acting as a network former. As a result, the glass-forming ability and chemical durability of the glasses were improved. The glasses showed antibacterial ability to gram-positive and -negative bacteria.

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“…Also the acquired enamel pellicle has been modified to increase the repulsive forces to incoming oral microflora [Schüpbach et al, 1996;Guan et al, in press]. There are other approaches including the development of anti-plaque vaccines [Bratthall and Gibbons, 1975;Hajishengallis et al, 1992] and the use of divalent metal cations [Harrap et al, 1984].…”

mentioning

confidence: 99%

Synergy of Binary Poly(Oxypropylene-Oxyethylene) Copolymers in Reducing Retention of Streptococcus sanguis to Hydroxyapatite

Guan¹,

Lilley²,

Marlow³

2003

Caries Res

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Binary poly(oxypropylene-oxyethylene) block copolymer systems have been investigated as a non-bactericidal approach to reduce the retention of an oral bacterium, Streptococcus sanguis. Using a previously validated hydroxyapatite-coated microtitre model to simulate the tooth, the performance of copolymer pairs was measured experimentally. A synergy index and an efficacy index were defined to describe the reduction of bacterial retention by the binary systems that comprise the copolymer pairs. Relationships between the synergy and efficacy indices and their associated compositions are given. The results obtained have been rationalised using a previously developed theoretical approach in conjunction with the binding energetics of species to surfaces.

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Human oral retention of zinc from mouthwashes containing zinc salts and its relevance to dental plaque control

Cited by 50 publications

References 17 publications

Dose-Related Effects of ZnCl₂on Dental Plaque Formation and Plaque Acidogenicity in vivo

Dose-Related Effects of ZnCl₂on Dental Plaque Formation and Plaque Acidogenicity in vivo

Preparation of Antibacterial ZnO-CaO-P<sub>2</sub>O<sub>5</sub>-Nb<sub>2</sub>O<sub>5</sub> Invert Glasses

Synergy of Binary Poly(Oxypropylene-Oxyethylene) Copolymers in Reducing Retention of <i>Streptococcus sanguis</i> to Hydroxyapatite

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Human oral retention of zinc from mouthwashes containing zinc salts and its relevance to dental plaque control

Cited by 50 publications

References 17 publications

Dose-Related Effects of ZnCl2on Dental Plaque Formation and Plaque Acidogenicity in vivo

Dose-Related Effects of ZnCl2on Dental Plaque Formation and Plaque Acidogenicity in vivo

Preparation of Antibacterial ZnO-CaO-P<sub>2</sub>O<sub>5</sub>-Nb<sub>2</sub>O<sub>5</sub> Invert Glasses

Synergy of Binary Poly(Oxypropylene-Oxyethylene) Copolymers in Reducing Retention of <i>Streptococcus sanguis</i> to Hydroxyapatite

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Dose-Related Effects of ZnCl₂on Dental Plaque Formation and Plaque Acidogenicity in vivo

Dose-Related Effects of ZnCl₂on Dental Plaque Formation and Plaque Acidogenicity in vivo