2016
DOI: 10.1136/gutjnl-2016-312580
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Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study

Abstract: Objective A history of periodontal disease and the presence of circulating antibodies to selected oral pathogens have been associated with increased risk of pancreatic cancer; however, direct relationships of oral microbes with pancreatic cancer have not been evaluated in prospective studies. We examine the relationship of oral microbiota with subsequent risk of pancreatic cancer in a large nested case-control study. Design We selected 361 incident adenocarcinoma of pancreas and 371 matched controls from two p… Show more

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Cited by 601 publications
(640 citation statements)
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“…They also found that a greater abundance of the phylum Fusobacteria was associated with decreased pancreatic cancer risk as well as its genus Leptotrichia [66]. Their finding was inconsistent with a recent cross-sectional study of eight patients, which found higher abundances of Leptotrichia and Porphyromonas in the saliva of pancreatic cancer patients compared to controls and those with other diseases, including non-cancerous pancreatic disease [18].…”
Section: Brief Additional Clinical Information On Leptotrichia Speciesmentioning
confidence: 99%
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“…They also found that a greater abundance of the phylum Fusobacteria was associated with decreased pancreatic cancer risk as well as its genus Leptotrichia [66]. Their finding was inconsistent with a recent cross-sectional study of eight patients, which found higher abundances of Leptotrichia and Porphyromonas in the saliva of pancreatic cancer patients compared to controls and those with other diseases, including non-cancerous pancreatic disease [18].…”
Section: Brief Additional Clinical Information On Leptotrichia Speciesmentioning
confidence: 99%
“…They were also recovered from oral plaque of guinea pigs [21] and feces of piglets [54], dental plaque from healthy individuals, plaque and saliva from patients with various types of caries, gingivitis, chronic periodontitis, and peri-implantitis [23,2527,34,35,37,38,44,45,47,49,52,59,60,62,6669,91,94], decayed tooth surfaces and discordant caries from intact enamel surfaces [53]. Leptotrichia species were also isolated from bronchoalveolar lavage fluid, and patients with leukocytosis, hypoxemia, and dyspnea [24].…”
Section: Brief Additional Clinical Information On Leptotrichia Speciesmentioning
confidence: 99%
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