Human Nonmercaptalbumin Is a New Biomarker of Motor Function

Ito, Sadayuki; Nakashima, Hiroaki; Ando, Kei; Kobayashi, Kazuyoshi; Machino, Masaaki; Seki, Tomohiro; Ishizuka, Shinya; Kanbara, Shunsuke; Koshimizu, Hiroyuki; Fujii, Ryosuke; Yamada, Hiroya; Ando, Yoshitaka; Ueyama, Jun; Kondo, Takaaki; Suzuki, Kôji; Hasegawa, Yukiharu

doi:10.3390/jcm10112464

Cited by 2 publications

(2 citation statements)

References 47 publications

(54 reference statements)

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“…Previous studies have reported that hypertension and smoking are risk factors for LS [17]. In addition, both LS and hearing loss are reportedly associated with oxidative stress [29]. We believe that lifestyle modifications, such as dietary modifications, including salt restriction and antioxidant intake, increased physical activity, and smoking cessation, may reduce the risk of LS and hearing loss.…”

Section: Discussionmentioning

confidence: 76%

Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults

Ito,

Nakashima,

Segi

et al. 2023

JCM

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The relationship between hearing and motor function as a function of aging is unclear. Therefore, we aimed to clarify the relationship between age-related hearing loss and locomotive syndrome. In total, 240 participants aged ≥40 years, whose hearing acuity and motor function had been measured, were included in this study. Patients with a hearing acuity of <35 dB and ≥35 dB were categorized into normal and low hearing acuity groups, respectively. Motor function was compared according to sex between the groups. Among men, those in the low hearing acuity group (51/100) were older, had a significantly slower walking speed, and had a higher prevalence of locomotive syndrome than those in the normal group. Among women, those in the low hearing group (14/140) were older and had a significantly slower gait speed than those in the normal group. The multivariate analysis showed that, in the low hearing acuity group, age and gait speed were risk factors in men, while age was the only risk factor in women. In conclusion, hearing loss was associated with walking speed. The association between hearing loss and locomotive syndrome was observed only in men. In the multivariate analysis, hearing loss was associated with walking speed only in men.

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Section: Discussionmentioning

confidence: 76%

Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults

Ito,

Nakashima,

Segi

et al. 2023

JCM

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“…Ito et al reported that the ratio of nonmercaptalbumin (HNA) to albumin (HMA), a marker of metabolic stress, can be a biomarker for LS in elderly subjects (≥ 65 years) [ 26 ]. The results for the relationship between a high HNA/HMA ratio and a high LS stage were thought to be related to the increase in oxidative stress and the exacerbation of LS.…”

Section: Discussionmentioning

confidence: 99%

Association between serum insulin-like growth factor 1 and locomotive syndrome in community-dwelling older people

Nakamura

Imaoka

Nakao

et al. 2022

BMC Musculoskelet Disord

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Background Locomotive syndrome (LS) is a condition in which mobility decreases, and it is known as a risk factor for elderly persons needing care in connection with sarcopenia and frailty. Prevention or delay of the onset of these diseases is important for preventing the need for care, and identification of biomarkers as indicators for appropriate intervention is useful. The present study aimed to clarify whether the serum insulin-like growth factor 1 (IGF-1) level, which has been reported to be related to sarcopenia and frailty, is related to LS. Methods The study participants were 133 elderly people living in a rural area in Japan. LS was assessed using Locomo-25, which is a self-administered questionnaire, and LS was defined as a Locomo-25 score ≥ 7 points. Serum IGF-1 and albumin levels were measured. A self-completed medical history questionnaire was used. Results On multiple linear regression analysis, age, IGF-1, osteoporosis, and osteoarthritis were significantly associated with the Locomo-25 score. The receiver-operating characteristic curve analysis of the IGF-1 level showed a threshold value of 82.0 ng/mL for discriminating non-LS and LS. The logistic regression analysis adjusted for osteoporosis, osteoarthritis, and the propensity score estimated from sex, age, and BMI showed that the odds ratio (OR) of the IGF-1 level for LS was 1.019 (95% confidence interval [CI], 1.002–1.039; p = 0.027), and the OR of IGF-1 ≤ 82 ng/mL for LS was 2.275 (95% CI 0.993–5.324; p = 0.052). Conclusions The present findings suggest that osteoporosis and osteoarthritis were associated with early LS, and a decrease of the serum IGF-1 level was a significant independent factor for early LS.

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Human Nonmercaptalbumin Is a New Biomarker of Motor Function

Cited by 2 publications

References 47 publications

Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults

Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults

Association between serum insulin-like growth factor 1 and locomotive syndrome in community-dwelling older people

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