2020
DOI: 10.1182/bloodadvances.2020002084
|View full text |Cite
|
Sign up to set email alerts
|

Human NK cells prime inflammatory DC precursors to induce Tc17 differentiation

Abstract: Adaptive immune responses are acknowledged to evolve from innate immunity. However, limited information exists regarding whether encounters between innate cells direct the generation of specialized T-cell subsets. We aim to understand how natural killer (NK) cells modulate cell-mediated immunity in humans. We found that human CD14+CD16− monocytes that differentiate into inflammatory dendritic cells (DCs) are shaped at the early stages of differentiation by cell-to-cell interactions with NK cells. Although a fr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
18
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7
1

Relationship

2
6

Authors

Journals

citations
Cited by 16 publications
(18 citation statements)
references
References 75 publications
0
18
0
Order By: Relevance
“…Promising antimicrobial activity was documented in three patients. Activated NK cells seem to be required for the generation of antibacterial specific adaptive immunity through inducing maturation of dendritic cells 30,31 . Furthermore, the anti‐tuberculosis activity of NK cells seems to vary with KIR haplotypes, suggesting that KIR variation may be related to tuberculosis susceptibility 32 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Promising antimicrobial activity was documented in three patients. Activated NK cells seem to be required for the generation of antibacterial specific adaptive immunity through inducing maturation of dendritic cells 30,31 . Furthermore, the anti‐tuberculosis activity of NK cells seems to vary with KIR haplotypes, suggesting that KIR variation may be related to tuberculosis susceptibility 32 …”
Section: Discussionmentioning
confidence: 99%
“…Activated NK cells seem to be required for the generation of antibacterial specific adaptive immunity through inducing maturation of dendritic cells. 30,31 Furthermore, the anti-tuberculosis activity of NK cells seems to vary with KIR haplotypes, suggesting that KIR variation may be related to tuberculosis susceptibility. 32 Immune reconstitution was predominantly T cells, although three patients demonstrated NK-cell-dominant reconstitution.…”
Section: Discussionmentioning
confidence: 99%
“…Past studies have shown the importance of IL-18-primed NK cells to promote recruitment and activation of effector CD8 + T cells via DC activation and migration ( 57 , 58 ). This current study shows that mice nasally dosed once with znBAZ develop a significant increase in the number of IFN-γ + CD4 + and CD8 + T cells in the lungs.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, IL-12- or IL-2-activated NK cells induce the maturation of DCs, which prime Th1 cells, whereas NK cells exposed to IL-4 impaired efficient DCs Th1 priming and might favor tolerogenic or Th-2 responses [ 92 , 93 ]. Recently, it was shown that NK cells can also prime inflammatory DCs to drive the differentiation of type 17 CD8 + T cells (Tc17), which have the capacity to produce IFN-γ and IL-17 [ 94 ].…”
Section: Implication Of Nk–dc Crosstalk In Cancer Immunitymentioning
confidence: 99%