Human neutrophil gelatinase-associated lipocalin: A new biomarker in asthma-COPD overlap syndrome

Akcali, Serap; Kurt, Bahar; Uçar, Fattma; Erdemir, Esra; Alay, Emine Figen

doi:10.1183/13993003.congress-2016.pa5014

Cited by 2 publications

(2 citation statements)

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“…The major findings of this study were as follows: (1) NGAL production was enhanced in allergies; however, increased NGAL production was not associated with a positive ECP test and a high sIgE score; (2) allergic patients without systemic inflammation did not differ from healthy individuals in terms of NGAL; and (3) NGAL was closely associated with TGF- β 1 and TNF- α , but not with ECP and sIgE. These findings are in accordance with the results of a previous study, which demonstrated that NGAL was a prognostic biomarker in asthma-COPD overlap syndrome characterized by airway inflammation [ 18 ].…”

Section: Discussionsupporting

confidence: 88%

Relationship between Neutrophil Gelatinase-Associated Lipocalin, Eosinophil Cationic Protein, Cytokines, and Atopic Sensitization in Patients with Allergic Diseases

Choi

Lee

Fujii

2022

BioMed Research International

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The effect of neutrophil gelatinase-associated lipocalin (NGAL) on eosinophil activation, atopic sensitization, and systemic inflammation in allergic diseases has rarely been investigated. This study aimed to investigate the relationship between NGAL, eosinophil cationic protein (ECP), cytokines, and allergen-specific immunoglobulin E (sIgE) in allergic diseases. A total of 136 patients with allergies and 58 healthy individuals were evaluated. The concentrations of NGAL, ECP, tumor necrosis factor-α (TNF-α), interleukin-5 (IL-5), sIgE, total IgE (tIgE), and high-sensitivity C-reactive protein (hsCRP) were measured. The transforming growth factor-β1 (TGF-β1) level was measured as a profibrotic marker of bronchial asthma. Allergic patients had significantly higher NGAL, ECP, and hsCRP levels than healthy individuals. However, there was no significant difference in NGAL levels between patients with positive and negative ECP tests and those with high and low sIgE scores. Asthmatic patients with elevated NGAL exhibited a significantly higher TGF-β1 level than those without elevated NGAL. However, no significant difference was observed in the ECP, IL-5, and sIgE levels between the two groups. Among the patients with a positive ECP test, subjects with elevated hsCRP had two times higher NGAL levels than those without elevated hsCRP. NGAL was positively correlated with TNF-α, TGF-β1, and hsCRP, but not with ECP, IL-5, tIgE, and sIgE. An elevated NGAL level led to a 1.3-fold increase in the prevalence of high TGF-β1 (odds ratio: 1.31; 95% CI: 1.04–2.58; P < 0.001 ). In conclusion, NGAL elevation may be more closely linked to allergic inflammation and a possible fibrotic change in the airways than to the severity of eosinophil activation and atopic sensitization.

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Section: Discussionsupporting

confidence: 88%

Relationship between Neutrophil Gelatinase-Associated Lipocalin, Eosinophil Cationic Protein, Cytokines, and Atopic Sensitization in Patients with Allergic Diseases

Choi

Lee

Fujii

2022

BioMed Research International

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“…HNL and CRP have mainly been used as diagnostic tools for distinguishing bacterial from viral infections [23, 24]. However, a few studies have associated HNL and CRP to airway inflammation and to the prediction of asthma status [25–27], but these markers seem to be resistant to corticosteroid treatment [28]. Several studies have emphasized the role of neutrophilic inflammation in corticosteroid-resistant asthma involving IL-8 as a potent mediator [29–31].…”

Section: Discussionmentioning

confidence: 99%

Characterization of a subgroup of non-type 2 asthma with cow’s milk hypersensitivity in young subjects

Tsolakis

Nordvall

Janson

et al. 2019

Clin Transl Allergy

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Background Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Objective Our aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins. Methods Sex- and age-matched subjects (10–35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow’s milk hypersensitivity but with IgE antibodies < 0.35 kU A /L (NAA; n = 24), non-atopic controls with IgE < 0.35 kU A /L (NAC; n = 24), and atopic asthmatics with IgE ≥ 0.35 kU A /L (AA; n = 29). Serum or plasma were analysed using the multi-allergen tests Phadiatop and fx5 (ImmunoCAP), a multiplex immunoassay comprising 92 inflammation-related proteins (Proseek Inflammation), and an ELISA for human neutrophil lipocalin (S-HNL). Fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, C-reactive protein (CRP), airway responsiveness to methacholine (PD 20 ), and asthma-related quality of life (mAQLQ) were also measured. Results NAA had lower FeNO ( p < 0.001) and B-Eos count ( p < 0.001), but scored worse on mAQLQ ( p = 0.045) compared with AA. NAA displayed higher levels of matrix metalloproteinase-1 (MMP-1) compared with both NAC ( p = 0.011) and AA ( p = 0.001), and lower PD 20 compared with NAC ( p < 0.001). In NAA, S-HNL correlated negatively with PD 20 (rho = − 0.048, p < 0.05) and CRP correlated negatively with mAQLQ (rho = − 0.439, p < 0.05). Conclusion In a subgroup of non-atopic young asthmatics with perceived cow’s milk hypersensitivity we observed poor asthma-related quality of life, airway hyperresponsiveness, and clinically relevant non-type 2 inflammation. MMP-1 was elevated in this group, which deserves further studies. Electronic supplementary material The online version of this article (10.1186/s13601-019-0250-2) contains supplementary material, which is available to authorized users.

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Human neutrophil gelatinase-associated lipocalin: A new biomarker in asthma-COPD overlap syndrome

Cited by 2 publications

References 0 publications

Relationship between Neutrophil Gelatinase-Associated Lipocalin, Eosinophil Cationic Protein, Cytokines, and Atopic Sensitization in Patients with Allergic Diseases

Relationship between Neutrophil Gelatinase-Associated Lipocalin, Eosinophil Cationic Protein, Cytokines, and Atopic Sensitization in Patients with Allergic Diseases

Characterization of a subgroup of non-type 2 asthma with cow’s milk hypersensitivity in young subjects

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