Human Nervous System

Katzman, Robert

doi:10.1002/cphy.cp110112

Cited by 7 publications

(2 citation statements)

References 177 publications

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“…The prevalence of dementia doubles every 5 years between the ages of 65 and 85 years, and about 25–33% of those more than 85 years of age have some dementia [9,10]. The elderly patient in the hospital or ICU is at a higher risk of developing delirium, which is partly related to an increased incidence of dementia and cognitive abnormalities in this age group [11].…”

Section: Pathophysiologic Considerations In the Elderly With Criticalmentioning

confidence: 99%

Critical Illness in the Elderly: Review of Pathophysiology of Aging and Outcome of Intensive Care

Chelluri¹

2001

J Intensive Care Med

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The goal of this article is to review the literature on age and its influence on the pathophysiology of critical illness, outcome after critical illness, and end of life decision making in critically ill elderly patients. Sources for this review included the MEDLINE database and bibliographies of original articles, reviews, and book chapters. The population is aging and the need for medical care and its costs increase with increasing age. A majority of the elderly lead independent lives, although some need help with various functional activities related to daily living. It is difficult to separate the effects of aging from the effects of the comorbidities that develop with increasing age. The physiologic reserve decreases in the elderly and they may not be able to tolerate a critical injury or illness as well as a younger individual. As the elderly are usually on multiple medications, they are prone to have more drug interactions and side effects, and need close monitoring of the drugs and adjustment of the dosage. Mortality after a critical illness in the elderly is higher compared to younger patients, and it is more related to the acuity of physiologic disturbance than age alone. The effect of age alone on long‐term outcome is not well studied, but individuals with poor functional status and/or increased comorbidities have a poor short‐term outcome. Functional status usually deteriorates after critical illness, but the long‐term survivors usually recover functional abilities, and they are satisfied with their quality of life. Decision making at the end of life is difficult because of the paucity of data on long‐term mortality and quality of life, lack of information about patient wishes, and the uncertainty of the prognosis. Because many elderly patients survive critical illness and may return to their previous lifestyle, age alone should not weigh heavily in end of life decisions. As with other age groups, end of life decisions in the elderly should be made after considering long‐term outcomes, patient goals, and the benefits and burdens of life‐sustaining technology.

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Section: Pathophysiologic Considerations In the Elderly With Criticalmentioning

confidence: 99%

Critical Illness in the Elderly: Review of Pathophysiology of Aging and Outcome of Intensive Care

Chelluri¹

2001

J Intensive Care Med

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“…Older adults generally exhibit reductions in strength and force control that can lead to diminished functional capabilities [26]. The diminished movement capabilities have been attributed to changes in the neuromuscular system including changes in the number and size of motor units [27][28][29], adaptations in the biophysical and discharge properties of motor neurons, and a decline in sensory capabilities [30]. These physiological adaptations accompany changes in the kinematic structure of movements in healthy older adults [31].…”

Section: Introductionmentioning

confidence: 99%

Age and Not the Preferred Limb Influences the Kinematic Structure of Pointing Movements

Kornatz

Poston

Stelmach

2021

JFMK

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In goal-directed movements, effective open-loop control reduces the need for feedback-based corrective submovements. The purpose of this study was to determine the influence of hand preference and aging on submovements during single- and two-joint pointing movements. A total of 12 young and 12 older right-handed participants performed pointing movements that involved either elbow extension or a combination of elbow extension and horizontal shoulder flexion with their right and left arms to a target. Kinematics were used to separate the movements into their primary and secondary submovements. The older adults exhibited slower movements, used secondary submovements more often, and produced relatively shorter primary submovements. However, there were no interlimb differences for either age group or for the single- and two-joint movements. These findings indicate that open-loop control is similar between arms but compromised in older compared to younger adults.

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Geriatric Psychopharmacology: A Complex Case of Psychosis Complicated by Neuroleptic Malignant Syndrome (NMS) and Metabolic Syndrome (MetS)

Velamoor

Pulagam

2018

Complex Clinical Conundrums in Psychiatry

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Human Nervous System

Cited by 7 publications

References 177 publications

Critical Illness in the Elderly: Review of Pathophysiology of Aging and Outcome of Intensive Care

Critical Illness in the Elderly: Review of Pathophysiology of Aging and Outcome of Intensive Care

Age and Not the Preferred Limb Influences the Kinematic Structure of Pointing Movements

Geriatric Psychopharmacology: A Complex Case of Psychosis Complicated by Neuroleptic Malignant Syndrome (NMS) and Metabolic Syndrome (MetS)

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