Human Nephrogenesis can Persist Beyond 40 Postnatal Days in Preterm Infants

Carpenter, James; Yarlagadda, Sunitha; VandenHeuvel, Katherine A.; Ding, Lili; Schuh, Meredith P.

doi:10.1016/j.ekir.2023.10.032

Cited by 3 publications

(1 citation statement)

References 43 publications

(53 reference statements)

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“…In this edition of Kidney International Reports, Carpenter and colleagues present a histological analysis of kidneys obtained from extremely preterm infants delivered between approximately 24 and 28 weeks who survived more than 40 days (cases) and from infants delivered between 30 and 36 weeks who survived fewer than 4 days (controls). 10 Kidneys from these 2 groups were matched for postmenstrual age. Kidneys from the 7 extremely preterm cases were larger than controls (normalized for both body weight and length).…”

mentioning

confidence: 99%

Postnatal Nephrogenesis in Preterm Infants: The Need to Safeguard Kidney Development After Birth

Nakatsugawa,

Sampogna

2024

Kidney International Reports

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mentioning

confidence: 99%

Postnatal Nephrogenesis in Preterm Infants: The Need to Safeguard Kidney Development After Birth

Nakatsugawa,

Sampogna

2024

Kidney International Reports

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Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats

DeFreitas,

Shelton,

Schmidt

et al. 2024

Sci Rep

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Premature infants are often exposed to hyperoxia. However, there is limited data regarding the mechanistic underpinnings linking neonatal hyperoxia exposure and its contribution to cardio-renal dysfunction in adults born preterm. Our objective was to determine whether neonatal hyperoxia induces systemic vascular stiffness and cardio-renal dysfunction in adulthood. Newborn rats were randomly assigned to room air (RA) or hyperoxia (85% O2) from postnatal day 1 to 14, then recovered in RA until 1 year of life. Arterial stiffness, cardio-renal histomorphometry, and fibrosis in the aorta, heart, and kidney were assessed. RNA-sequencing (RNA-seq) of the aorta and kidney was also done. Adult rats exposed to neonatal hyperoxia had increased aortic and mesenteric artery stiffness as demonstrated by wire and pressure myography. They also had cardiomyocyte hypertrophy, glomerulomegaly, and tubular injury. Hyperoxia exposure altered the transcriptome profile associated with fibrosis and matrix remodeling in the aorta and kidney. There was also increased TGF-β1 levels and fibrosis in the aorta, left ventricle, and kidney. In conclusion, neonatal hyperoxia exposure was associated with systemic vascular and cardio-renal alterations in 1-year-old rats. Further studies to determine how targeted therapies could reprogram cardio-renal injury after neonatal hyperoxia exposure are indicated.

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Renal Tubular Epithelium in the Development of Renal Cell Carcinoma

Shafi,

Zahra,

Shah

2024

Preprint

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Objective: The objective of this study is to determine how dysregulations in developmental genes, transcription factors and signaling pathways of renal tubular epithelium contribute to Renal Cell Carcinoma development. Background: Renal Cell Carcinoma (RCC) presents a significant challenge in oncology due to its diverse clinical behaviors and inherent heterogeneity. Understanding its developmental dynamics is crucial for finding therapeutic opportunities. Key genes, TFs and signaling pathways, including PAX2, WT1, Wnt/β-catenin, and BMP, play key roles in RCC pathogenesis. This study aims to investigate RCC's origins and development, paving the way for possible effective, personalized interventions and improving patient outcomes. Methods: Databases, including PubMed, MEDLINE, Google Scholar, and open access/ subscription-based journals were searched for published articles without any date restrictions, to investigate the key genetic architecture and developmental dynamics contributing to the development and origins of RCC. Based on the criteria mentioned in the methods section, studies were systematically reviewed to investigate RCC oncogenesis. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Results: This study investigates the processes guiding Renal Cell Carcinoma (RCC) initiation. PAX2, WT1, RET, GATA3, HNF1B, OSR1 emerge as architects, controlling developmental dynamics. Transcription factors SIX2, HOXD11, EMX2 regulate renal stem/progenitor cell fate and enhance stemness, influencing RCC aggressiveness. Signaling pathways—Wnt/β-catenin, Notch, FGF, Shh, RAAS, BMP—act as regulators triggering epithelial-mesenchymal transition (EMT) and fostering angiogenesis. BMP and Wnt/β-catenin pathways drive EMT, enhancing stemness, key RCC drivers. NF-κB-mediated inflammation contributes to the immune microenvironment, potentially fueling RCC progression. These results point to the significance of investigating RCC through the lens of developmental dynamics. Conclusion: Renal Cell Carcinoma (RCC) originates from renal tubular epithelial cells, and understanding the developmental processes is crucial for finding its pathogenesis and origins. Genes like PAX2, WT1, RET, GATA3, HNF1B, OSR1, and transcription factors SIX2, HOXD11, EMX2, shape epithelial cell development in renal tubules. Signaling pathways such as Wnt/β-catenin, Notch, FGF, Hedgehog, RAAS, and BMP critically participate. Dysregulation in these key regulators, including BMP signaling disruption, may lead to a pathologic state, impacting cell fate, inflammation, and contributing to RCC development.

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Human Nephrogenesis can Persist Beyond 40 Postnatal Days in Preterm Infants

Cited by 3 publications

References 43 publications

Postnatal Nephrogenesis in Preterm Infants: The Need to Safeguard Kidney Development After Birth

Postnatal Nephrogenesis in Preterm Infants: The Need to Safeguard Kidney Development After Birth

Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats

Renal Tubular Epithelium in the Development of Renal Cell Carcinoma

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