Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

Gold, Marielle C.; Cerri, Stefania; Smyk-Pearson, Susan; Cansler, Meghan; Vogt, Todd; Delepine, Jacob; Winata, Ervina; Swarbrick, Gwendolyn; Chua, Wei Jen; Yu, Yanbo; Lantz, Olivier; Cook, Matthew S.; Null, Megan; Jacoby, David B.; Harriff, Melanie J.; Lewinsohn, Deborah A.; Hansen, Ted H.; Lewinsohn, David

doi:10.1371/journal.pbio.1000407

Cited by 570 publications

(958 citation statements)

References 51 publications

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“…MAIT cells have been shown to detect a variety of microbes through the recognition of vitamin B metabolites presented by MR1 12, 81, 82. Furthermore, these cells were found to largely overlap with a unique subset of CD8+ T‐cells expressing CD161 at a high level, CD161++ CD8+ T‐cells 11, 15…”

Section: Subsets Of Cd8+ T‐cellsmentioning

confidence: 99%

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes

2018

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SummaryNew data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely separately, the emerging innate functions of T‐cells and, similarly, the adaptive functions of NK cells suggest that many behaviours can be considered in parallel. In this review we compare the innate functions of CD8+ T‐cells (especially mucosal‐associated invariant T‐cells) and those of NK cells, and how these relate to expression of phenotypic markers, especially CD161 and CD56.

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Section: Subsets Of Cd8+ T‐cellsmentioning

confidence: 99%

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes

2018

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“…AECs play a role as immune sentinels after exposure to Mtb by presenting antigen to mucosal‐associated invariant T cells (MAITs) (Harriff et al ., 2014) and stimulating them to produce interferon (IFN)‐γ, tumour necrosis factor (TNF)‐α and granzyme, factors that may contribute to Mtb clearance. MAIT cells rapidly respond to infection, providing an early IFN‐γ boost to activate macrophages (Gold et al ., 2010). Crucially, AECs control the composition of ASL.…”

Section: Cells Involved In the Innate Immune Response To Tb In Humansmentioning

confidence: 99%

The innate immune response in human tuberculosis

2015

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Summary M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini‐review, we discuss these host–pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome‐wide association studies).

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“…Increased MAIT cells in lung lesions of two patients with active TB, suggests that migration to the infected tissue is the cause of the decreased circulating numbers. In a separate study, ex vivo analysis also demonstrated that mycobacterium tuberculosis (Mtb)-reactive MAIT cells were enriched in the lungs of patients with active TB, and responded to Mtb-infected MR1-expressing lung epithelial cells [79].…”

Section: Antibacterial Activity Of Mait Cells In Vivo In Humansmentioning

confidence: 95%

“…In humans evidence of the close association between bacterial infection and MAIT cells was initially shown in patients suffering from pulmonary bacterial infections [76,79]. Decreased circulating numbers of MAIT cells were observed in patients suffering from tuberculosis (TB) compared to healthy controls and cancer patients.…”

Section: Antibacterial Activity Of Mait Cells In Vivo In Humansmentioning

confidence: 99%