Human mucocutaneous leishmaniasis in Três Braços, Bahia - Brazil: an area of Leishmania braziliensis braziliensis transmission. II. Cutaneous disease. Presentation and evolution

Llanos-Cuentas, Elmer A.; Marsden, Philip D.; Lago, Edinaldo L.; Barreto, A. C.; Cuba, César Augusto Cuba; Johnson, Warren D.

doi:10.1590/s0037-86821984000400003

Cited by 66 publications

(18 citation statements)

References 13 publications

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“…Both study groups reflected the common profile of the disease seen in Rio de Janeiro: most patients had less than three months of disease, one or few lesions and the typical ulcer was the most common disease presentation 21 24 . The time elapsed between start of therapy and complete lesion healing could be accurately estimated for most patients in both groups and was similar to previous reports on cutaneous leishmaniasis due to L. braziliensis in Brazil 14 . Both schedules resulted in cure rates within the range found in previous studies on antimonial therapy of American cutaneous leishmaniasis 12 23 and no difference was observed between the groups in this regard.…”

Section: Discussionsupporting

confidence: 86%

“…The intermittent regimen of ten-day courses of antimonial therapy interrupted by ten-day intervals 16 , recommended by the manufacturers of the antimonial drugs used in leishmaniasis, has been widely used in Brazil with success 14 . We evaluated the impact of the substitution of this intermittent regimen by the continuous therapy, currently recommended by the Brazilian Ministry of Health, in outpatient units located in the municipality of Rio de Janeiro, with regard to efficacy, adherence, frequency of side effects and the time to cure cutaneous leishmaniasis caused by L. braziliensis.…”

Section: Discussionmentioning

confidence: 99%

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An intermittent schedule is better than continuous regimen of antimonial therapy for cutaneous leishmaniasis in the municipality of Rio de Janeiro, Brazil

Azeredo-Coutinho

Mendonça

2002

Rev. Soc. Bras. Med. Trop.

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This study reviews a series of cutaneous leishmaniasis cases diagnosed and treated in outpatient units in the municipality of Rio de Janeiro, where the intermittent schedule of antimonial therapy was replaced by the continuous regimen. Both schedules were based on daily intramuscular injections of pentavalent antimonial. Forty-nine subjects received the intermittent regimen, consisting of three ten-day series alternated with ten-day rest intervals whereas seventy-one patients received the continuous regimen during 20 consecutive days. The study groups had similar composition regarding age, sex and clinical condition. The cure rate was significantly higher in the group receiving the intermittent schedule than in the group receiving continuous therapy (89.8% vs 63.3%). Moreover, loss to follow-up was significantly more frequent in the group receiving continuous therapy (19.7% vs 4.1% in the intermittent therapy). Under field conditions, the intermittent regimen provided higher effectiveness and adherence than the continuous schedule.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

An intermittent schedule is better than continuous regimen of antimonial therapy for cutaneous leishmaniasis in the municipality of Rio de Janeiro, Brazil

Azeredo-Coutinho

Mendonça

2002

Rev. Soc. Bras. Med. Trop.

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“…12 The CL patients followed in this report displayed similar clinical characteristics at the time of diagnosis as those described by others. 13 Age positively correlated with the size of the lesion and this association was not caused by a longer time before reaching medical assistance. Endocrine, hematological, and nutritional aspects related to aging and, more importantly, local vascular deficiencies may participate in determining the size of lesions in these individuals.…”

Section: Discussionmentioning

confidence: 79%

Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis

Oliveira¹,

Báfica²,

Rosato³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological evaluations in a 2-year period. Statistical analysis revealed that healing time (P = 0.029), age (P = 0.002), and TNF levels (P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to improve healing in CL patients with severe lesions.

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“…As características epidemiológicas e clínicas dos pacientes avaliados são representativas da população atingida pela leishmaniose tegumentar produzida por L. (V.) braziliensis na região do estudo 13 .…”

Section: Discussionunclassified

Sensibilidade antimicrobiana de bactérias aeróbicas isoladas de úlceras leishmanióticas, em Corte de Pedra, BA

Vera

Macedo

Ciuffo

et al. 2006

Rev. Soc. Bras. Med. Trop.

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A lesão cutânea ulcerada, manifestação clínica mais freqüente da leishmaniose tegumentar, geralmente localizada em membros inferiores, permanece ativa durante meses, expondo-se à colonização por microorganismos, componentes ou não da flora normal da pele. As condições de calor, umidade e má higiene, que acontecem freqüentemente em ambiente rural nas regiões tropicais, associadas à proximidade dessas úlceras com o solo, favorecem, sobremodo, a colonização por diversas bactérias 20 .Existem poucos relatos sobre a prevalência de bactérias em úlceras leishmanióticas. ABSTRACTA prospective study regarding aspects of antimicrobial susceptibility aspects was realized among patients with tegumentary leishmaniasis in Corte de Pedra, Bahia. Cases were composed mainly of adolescent and adult farmer patients with single lesions. Staphylococcus aureus predominated (83%) in the culteres with susceptibility to the majority of antibiotics. A mixed bacterial flora in ulcers was encountered in 37 (44,1%) patients. Among the Gram-negative bacteria isolated, Enterobacter sp (13.1%), Proteus sp (8.3%), Pseudomonas aeruginosa (7.1%) and Klebsiella sp (7.1%) were mainly found with susceptibility to ciprofloxacin, aminoglycosides, third generation cephalosporin and carbapenems.

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Human mucocutaneous leishmaniasis in Três Braços, Bahia - Brazil: an area of Leishmania braziliensis braziliensis transmission. II. Cutaneous disease. Presentation and evolution

Cited by 66 publications

References 13 publications

An intermittent schedule is better than continuous regimen of antimonial therapy for cutaneous leishmaniasis in the municipality of Rio de Janeiro, Brazil

An intermittent schedule is better than continuous regimen of antimonial therapy for cutaneous leishmaniasis in the municipality of Rio de Janeiro, Brazil

Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis

Sensibilidade antimicrobiana de bactérias aeróbicas isoladas de úlceras leishmanióticas, em Corte de Pedra, BA

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