Human motor evoked responses to paired transcranial magnetic stimuli

Valls‐Solé, Josep; Pascual‐Leone, Álvaro; Wassermann, Eric M.; Hallett, Mark

doi:10.1016/0168-5597(92)90048-g

Cited by 610 publications

(413 citation statements)

References 27 publications

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“…In our study the TMS interference in the landmark task manifested for P4 scalp-position as early as 50 ms post-stimulus might be explained by long-lasting effects (i.e. effects that last as long as 50 ms after the single pulse) at the cortical level induced by single-pulse TMS [27,28]. Our results are consistent with a previous TMS study [15] showing it is possible to interfere with visuo-spatial processing by stimulating the right PPC although repetitive TMS and different parietal zones of stimulation (P5 and P6 instead of P3 and P4 in the present study) were used in this earlier experiment.…”

Section: Discussionmentioning

confidence: 99%

Event-related TMS over the right posterior parietal cortex induces ipsilateral visuo-spatial interference

Vandermeeren¹,

Olivier²,

Gelder³

2001

Neuroreport

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The right posterior parietal cortex (PPC) is implicated in visuo-spatial processing, as illustrated by patients with visuo-spatial neglect, but the precise time-course of its contribution is still an open question. In the present study we assessed whether single-pulse transcranial magnetic stimulation (TMS) can interfere with the performance of normal subjects in a standard visuo-spatial task. Participants had to perform a landmark task while TMS was applied over the right PPC, the homologue region in the left hemisphere or the right primary motor cortex. Stimulation was time-locked to the stimulus presentation with a stimulus onset asynchrony (SOA) varying between 50 and 200 ms. Our results indicate that TMS interfered mainly with the visuo-spatial task when applied over the right PPC at an early stage (50 ms post-stimulus). The interference effect of single-pulse TMS in the present visuo-spatial processing is revealed by a processing cost for ipsilateral targets. These results are ... The right posterior parietal cortex (PPC) is implicated in visuospatial processing, as illustrated by patients with visuo-spatial neglect, but the precise time-course of its contribution is still an open question. In the present study we assessed whether single-pulse transcranial magnetic stimulation (TMS) can interfere with the performance of normal subjects in a standard visuo-spatial task. Participants had to perform a landmark task while TMS was applied over the right PPC, the homologue region in the left hemisphere or the right primary motor cortex. Stimulation was time-locked to the stimulus presentation with a stimulus onset asynchrony (SOA) varying between 50 and 200 ms. Our results indicate that TMS interfered mainly with the visuo-spatial task when applied over the right PPC at an early stage (50 ms post-stimulus). The interference effect of single-pulse TMS in the present visuo-spatial processing is revealed by a processing cost for ipsilateral targets. These results are in agreement with neuropsychological and brain imaging studies showing a right hemispheric dominance in visuo-spatial processing but add crucial information about the time-course of visuo-spatial processing within the right PPC.

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Section: Discussionmentioning

confidence: 99%

Event-related TMS over the right posterior parietal cortex induces ipsilateral visuo-spatial interference

Vandermeeren¹,

Olivier²,

Gelder³

2001

Neuroreport

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“…For most studies using LICI to investigate GABA B mediated inhibition, an ISI of 100 ms is generally used, as this is thought to produce maximum inhibition of the MEP [9]. However, LICI can be assessed over a broad range of intervals [9,35], with measurements at different ISIs often assumed to reflect comparable mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…However, LICI can be assessed over a broad range of intervals [9,35], with measurements at different ISIs often assumed to reflect comparable mechanisms. Within the current study, we found several lines of evidence suggesting similarities between the mechanisms contributing to LICI at each ISI, including correlations between the slope of the N100 produced by the LICI 100 conditioning stimulus and MEP inhibition produced in both LICI conditions (Table 1); correlations between LICI conditions for inhibition of the late TEP peaks (N100 and P180, Table 2), and no topographical difference between conditions for normalised LICI values (Fig 6).…”

Section: Discussionmentioning

confidence: 99%

Investigating TMS–EEG Indices of Long-Interval Intracortical Inhibition at Different Interstimulus Intervals

et al. 2017

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After the embargo period via non-commercial hosting platforms such as their institutional repository  via commercial sites with which Elsevier has an agreement In all cases accepted manuscripts should: link to the formal publication via its DOI  bear a CC-BY-NC-ND license -this is easy to do, click here to find out how  if aggregated with other manuscripts, for example in a repository or other site, be shared in alignment with our hosting policy  not be added to or enhanced in any way to appear more like, or to substitute for, the published journal article This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 Page 2 Investigating TMS-EEG indices of long-interval intracortical inhibition at different interstimulus intervals Highlights TMS-evoked EEG potentials were reduced after long-interval intracortical inhibition (LICI) with interstimulus intervals (ISIs) of 100 ms and 150 ms  Inhibition of P30 was observed following LICI at 100 ms, but was absent following LICI at 150 ms  Topographical analyses suggested that global inhibition of P30, N40 and P180, but not N100, differed between ISIs  Our findings suggest that LICI at different ISIs likely has complex contributions from common mechanisms AbstractBackground: Long-interval intracortical inhibition (LICI) is a transcranial magnetic

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“…The mean amplitude of the conditioned MEP at each ISI was expressed as a percentage of the mean size of the unconditioned test pulse. SICI was taken as the mean percentage inhibition at ISIs of 2 and 4 ms, whereas ICF was taken as the mean facilitation at ISIs of 9 and 12 ms. Another protocol tested LICI with two suprathreshold stimuli applied with ISIs of 50, 100, and 150 ms (Valls-Sole et al, 1992). The intensity of both stimuli was set to the relatively low value of 110% RMT to avoid floor effects.…”

Section: Experiments 2 (Motor Cortex Excitability)mentioning

confidence: 99%

Cortical Hypoexcitability in Chronic Smokers? A Transcranial Magnetic Stimulation Study

Lang

Hasan

Sueske

et al. 2007

Neuropsychopharmacol

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Studies in animal models and humans indicate that chronic nicotine intake influences neuronal excitability, resulting in functional and structural CNS changes. The aim of the present study was to explore human primary motor cortex (M1) excitability with transcranial magnetic stimulation (TMS) in chronic smokers. A total of 44 right-handed volunteers, aged 20-30 years, participated in the study. Chronic smokers were compared with age-and sex-matched healthy nonsmokers. We tested cortical excitability with single-and pairedpulse TMS to the left M1 and short-latency afferent inhibition (SAI) by combining median nerve stimulation and motor cortex TMS. Compared with nonsmoking controls, chronic smokers showed a significantly larger amount of SAI, which is thought to depend upon the activity of cholinergic inhibitory circuits produced by somatosensory inputs. Moreover, TMS-evoked inhibitory cortical silent periods were prolonged, whereas paired-pulse intracortical facilitation and motor-evoked potentials during moderate contraction were reduced. The results suggest that chronic nicotine intake may not only strengthen cholinergic inhibitory circuits, but could also be associated with enhanced inhibitory and reduced facilitatory mechanism of specific neuronal circuits in motor cortex. These changes may form a physiological basis for neurobiological and behavioral variations associated with chronic smoking.

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Human motor evoked responses to paired transcranial magnetic stimuli

Cited by 610 publications

References 27 publications

Event-related TMS over the right posterior parietal cortex induces ipsilateral visuo-spatial interference

Event-related TMS over the right posterior parietal cortex induces ipsilateral visuo-spatial interference

Investigating TMS–EEG Indices of Long-Interval Intracortical Inhibition at Different Interstimulus Intervals

Cortical Hypoexcitability in Chronic Smokers? A Transcranial Magnetic Stimulation Study

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