Human Milk Micronutrients and Child Growth and Body Composition in the First 2 years: A Systematic Review

Reyes, Sarah M.; Brockway, Meredith (Merilee); McDermid, Joann M.; Chan, Deborah; Granger, Matthew; Refvik, Rebecca; Sidhu, Karanbir K.; Musse, Suad; Monnin, Caroline; Lotoski, Larisa; Geddes, Donna T.; Jehan, Fyezah; Kolsteren, Patrick; Allen, Lindsay H.; Hampel, Daniela; Eriksen, Kamilla G.; Rodriguez, Natalie; Azad, Meghan B.

doi:10.1016/j.advnut.2023.06.005

Cited by 10 publications

(14 citation statements)

References 67 publications

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“…Echoing the concerns expressed by Reyes et al. (2023) [ 112 ], there is a continued need to examine HM from a systems perspective. Many HM components are interrelated and should be considered in concert with each other.…”

Section: Discussionmentioning

confidence: 99%

Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years: A Systematic Review

Brockway,

Daniel,

Reyes

et al. 2024

Advances in Nutrition

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Section: Discussionmentioning

confidence: 99%

Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years: A Systematic Review

Brockway,

Daniel,

Reyes

et al. 2024

Advances in Nutrition

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“…Studies exploring associations of maternal nutritional status with the vitamin composition of breastmilk have revealed that some vitamins might be inadequate for the growing infant, as a consequence of compromised maternal nutritional status ( 87 – 97 ) and poor maternal diet ( 97 – 100 ). However, the latest systematic review on HM components and infant anthropometry in the first 2 years of life among term infants uncovered no eligible studies for several vitamins including, riboflavin, C, D, E, and K and concluded that for others, the available evidence was largely inconclusive and further studies were needed ( 101 ). In our exploratory study in Guatemala where most women breastfeed but infants experience growth faltering by 3 months ( 40 , 102 ), we were able to observe correlations between selected nutrient intakes, the HMM, and infant growth.…”

Section: Discussionmentioning

confidence: 99%

Human milk microbiome: associations with maternal diet and infant growth

Ajeeb,

Gonzalez,

Solomons

et al. 2024

Front. Nutr.

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IntroductionIngestion of human milk (HM) is identified as a significant factor associated with early infant gut microbial colonization, which has been associated with infant health and development. Maternal diet has been associated with the HM microbiome (HMM). However, a few studies have explored the associations among maternal diet, HMM, and infant growth during the first 6 months of lactation.MethodsFor this cross-sectional study, Mam-Mayan mother-infant dyads (n = 64) were recruited from 8 rural communities in the Western Highlands of Guatemala at two stages of lactation: early (6–46 days postpartum, n = 29) or late (109–184 days postpartum, n = 35). Recruited mothers had vaginally delivered singleton births, had no subclinical mastitis or antibiotic treatments, and breastfed their infants. Data collected at both stages of lactation included two 24-h recalls, milk samples, and infant growth status indicators: head-circumference-for-age-z-score (HCAZ), length-for-age-z-score (LAZ), and weight-for-age-z-score (WAZ). Infants were divided into subgroups: normal weight (WAZ ≥ −1SD) and mildly underweight (WAZ < −1SD), non-stunted (LAZ ≥ −1.5SD) and mildly stunted (LAZ < −1.5SD), and normal head-circumference (HCAZ ≥ −1SD) and smaller head-circumference (HCAZ < −1SD). HMM was identified using 16S rRNA gene sequencing; amplicon analysis was performed with the high-resolution ANCHOR pipeline, and DESeq2 identified the differentially abundant (DA) HMM at the species-level between infant growth groups (FDR < 0.05) in both early and late lactation.ResultsUsing both cluster and univariate analyses, we identified (a) positive correlations between infant growth clusters and maternal dietary clusters, (b) both positive and negative associations among maternal macronutrient and micronutrient intakes with the HMM at the species level and (c) distinct correlations between HMM DA taxa with maternal nutrient intakes and infant z-scores that differed between breast-fed infants experiencing growth faltering and normal growth in early and late lactation.ConclusionCollectively, these findings provide important evidence of the potential influence of maternal diet on the early-life growth of breastfed infants via modulation of the HMM.

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“…Infant growth has been studied intensively in relation to many different factors, including feeding practices and HM components 42 . However, few, if any, have taken a systems biology approach.…”

Section: Discussionmentioning

confidence: 99%

“…Despite this large body of literature, the intricate relationships between the multitude of HM components and a plethora of maternal, infant, and environmental factors are poorly understood because research has typically focused on selected modalities and individual HM components or component types 42 . There is a growing recognition among researchers that multidisciplinary and systems biology approaches are required to decipher these complex relationships 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

Multimodal machine learning for modeling infant head circumference, mothers’ milk composition, and their shared environment

Becker,

Fehr,

Goguen

et al. 2024

Sci Rep

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Links between human milk (HM) and infant development are poorly understood and often focus on individual HM components. Here we apply multi-modal predictive machine learning to study HM and head circumference (a proxy for brain development) among 1022 mother-infant dyads of the CHILD Cohort. We integrated HM data (19 oligosaccharides, 28 fatty acids, 3 hormones, 28 chemokines) with maternal and infant demographic, health, dietary and home environment data. Head circumference was significantly predictable at 3 and 12 months. Two of the most associated features were HM n3-polyunsaturated fatty acid C22:6n3 (docosahexaenoic acid, DHA; p = 9.6e−05) and maternal intake of fish (p = 4.1e−03), a key dietary source of DHA with established relationships to brain function. Thus, using a systems biology approach, we identified meaningful relationships between HM and brain development, which validates our statistical approach, gives credence to the novel associations we observed, and sets the foundation for further research with additional cohorts and HM analytes.

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Human Milk Micronutrients and Child Growth and Body Composition in the First 2 years: A Systematic Review

Cited by 10 publications

References 67 publications

Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years: A Systematic Review

Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years: A Systematic Review

Human milk microbiome: associations with maternal diet and infant growth

Multimodal machine learning for modeling infant head circumference, mothers’ milk composition, and their shared environment

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