Human microbiome and cardiovascular diseases

Alam, Md. Jahangir; Puppala, Vaishnavi; Uppulapu, Shravan Kumar; Das, Bhabatosh; Banerjee, Sanjay K.

doi:10.1016/bs.pmbts.2022.07.012

Cited by 8 publications

(8 citation statements)

References 321 publications

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“…Probiotic supplementation, fecal donation, and altering gut microbiota makeup might all be active study topics for the prevention and treatment of coronary heart disease ( 89 ). Several pathological conditions in the gastrointestinal tract may compromise the intestinal barrier, allowing bacteria and their metabolites to translocate to remote organs such as the heart, which may ultimately be in connection with the evolution of systemic inflammation and cardiovascular disease ( 90 ). Changes in fecal microbiota have been associated with many disease states, such as cardiovascular disease (CVD), phenylacetylglutamine (PAG) and trimethylamine N-oxide (TMAO) more recently are gut microbiota-dependent metabolites whose blood levels have been associated with CVD risk in large-scale clinical studies ( 91 ).…”

Section: Potential Mechanismmentioning

confidence: 99%

Cardiovascular disease and depression: a narrative review

Li,

Zhou,

Wang

et al. 2023

Front. Cardiovasc. Med.

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In clinical practice, it is frequently observed that cardiac and psychological disorders frequently co-occur, leading to the emergence of a field known as cardiovascular disease with depression. Depression, in particular, poses a remarkable risk for the evolution of cardiovascular disease and intimately relates to adverse cardiovascular outcomes and mortality. Moreover, individuals who are depressed exhibit a higher susceptibility to developing cardiovascular disease compared to those in good health. Patients diagnosed with cardiovascular disease with depression disease face a heightened risk of mortality within a 5-year timeframe, and their prognosis remains unsatisfactory even after receiving treatment targeting a single disorder, with a notable recurrence rate. Psychological interventions in conjunction with medications are commonly employed in clinical settings for treating patients with cardiovascular disease and depression diseases, albeit with limited effectiveness and unfavorable prognosis. Traditional Chinese medicine (TCM), such as Shuangxinfang, Chaihujialonggumuli, and Yixin Ningshen Tablet, etc., have been reported and have Therapeutic effects in patients with cardiovascular disease combined with depression. Despite numerous articles documenting a notable association between heart disease and depression, there exists a dearth of studies elucidating the precise pathogenesis and target of action for cardiovascular disease with depression diseases. This article endeavors to consolidate the epidemiological data, potential pathogenic mechanisms, and available treatment modalities for cardiovascular disease with depression diseases. Its primary objective is to unveil plausible co-morbid mechanisms and suitable treatment approaches, thereby offering novel insights for the prevention, diagnosis, and management of cardiovascular disease with depression diseases.

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Section: Potential Mechanismmentioning

confidence: 99%

Cardiovascular disease and depression: a narrative review

Li,

Zhou,

Wang

et al. 2023

Front. Cardiovasc. Med.

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“…Furthermore, plant-based diets that are low in fat and high in fibre have the potential to positively alter the microbial composition of the intestine, shifting the microbiome environment towards beneficial bacteria like Prevotella and Bacteroides , while reducing the presence of Firmicutes [ 44 ]. Imbalances in the gut microbiota in turn have also been associated with conditions such as obesity, CVD and depression [ 45 , 46 ]. Available evidence suggests there is a bidirectional relationship between OSA and the composition of the microbiota [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Plant-based and vegetarian diets are associated with reduced obstructive sleep apnoea risk

Melaku,

Zhao,

Adams

et al. 2024

ERJ Open Res

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IntroductionObstructive sleep apnoea (OSA) and obesity commonly coexist. Weight loss and exercise are recommended management options for OSA. However, most of the current evidence on diet and OSA is focused on calorie restriction rather than diet quality. The aim of the present study was to determine the association of plant-based dietary indices (PDI) with OSA risk.MethodsCross-sectional data from 14 210 participants of the National Health and Nutrition Examination Survey who provided dietary information using the 24-hour recall method were used. PDI – including healthy (hPDI), unhealthy (uPDI) and pro-vegetarian diet index (PVDI) – were determined. OSA risk was determined using the STOP-BANG questionnaire. Logistic regression was used to determine the relationship between dietary indices and OSA risk.ResultsHigher adherence to PDI (odds ratio (OR)Q5versusQ1=0.81; 95% confidence interval (CI): 0.66–1.00), hPDI (OR=0.83; 95% CI: 0.69–1.01) and PVDI (OR=0.84; 95% CI: 0.68–1.05) was inversely associated with OSA risk, whereas higher consumption of an unhealthy plant-based diet (OR=1.22; 95% CI: 1.00–1.49) was positively associated with OSA. Sex differences in estimates were observed for PDI in males (OR=0.71; 95% CI: 0.56–0.90)versusfemales (OR=0.93; 95% CI: 0.68–1.28), hPDI in males (OR=0.90; 95% CI: 0.68–1.18)versusfemales (OR=0.77; 95% CI: 0.54–1.09) and uPDI in males (OR=1.13; 95% CI: 0.89–1.44)versusfemales (OR=1.42; 95% CI: 1.03–1.97) but not for PVDI.ConclusionsHigher adherence to a healthy plant-based diet is associated with reduced OSA risk, while an unhealthy plant-based diet has a positive association. The magnitude of these associations differs by sex. Further longitudinal studies are warranted.

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“…Gut microbiota participates in the onset and development of metabolic diseases such as HLP in the host via regulating metabolic and immunomodulatory pathways, and thus gut microbiota can serve as an important biomarker (Schoeler & Caesar, 2019). In a study by Wang et al (2018), the abundance and diversity of the gut microbiota vulgatus to ApoE-deficient mice reduces plasma LPS levels and atherosclerotic lesion formation (Alam et al, 2022). B. thetaiotaomicron is a gut microbial species associated with obesity.…”

Section: Discussionmentioning

confidence: 99%

“…From metagenomics analysis, we revealed that GLF‐217 altered the abundance of B. dorei , B. faecichinchillae, B. vulgatus , B. thetaiotaomicron , L. reuteri , and A. muciniphila at the species level. Gavage of B. dorei and B. vulgatus to ApoE‐deficient mice reduces plasma LPS levels and atherosclerotic lesion formation (Alam et al, 2022). B. thetaiotaomicron is a gut microbial species associated with obesity.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of Lactobacillus fermentum GLF‐217 on hyperlipidemia in high‐fat diet golden hamsters by regulating gut microbiota

Wang,

et al. 2023

Food Bioengineering

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To investigate the hypolipidemic and modulation effects of probiotics, the golden hamster of hyperlipidemia model was established and intervened with Lactobacillus fermentum GLF‐217 (GLF‐217) and lovastatin (LOV) for 6 weeks. Body weight and serum biochemical indexes were measured, and liver, colonic contents, and feces were collected after autopsy for pathological and gut microbiota analysis. The results showed that the intervention of GLF‐217 and LOV could significantly reduce serum lipid levels and liver fat accumulation in golden hamsters on a high‐fat diet, more importantly, the LOV intervention could cause damage to the liver. The LOV intervention significantly reduced the contents of short‐chain fatty acids (SCFAs) in the colonic and downregulated the abundance of SCFAs‐producing bacteria, but GLF‐217 intake increased butyric acid, thus reducing blood lipids and protected the liver. This study elucidates the possible mechanism of the hypolipidemic effect of probiotics in terms of regulating gut microbiota.

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Human microbiome and cardiovascular diseases

Cited by 8 publications

References 321 publications

Cardiovascular disease and depression: a narrative review

Cardiovascular disease and depression: a narrative review

Plant-based and vegetarian diets are associated with reduced obstructive sleep apnoea risk

Beneficial effect of Lactobacillus fermentum GLF‐217 on hyperlipidemia in high‐fat diet golden hamsters by regulating gut microbiota

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