Human metapneumovirus in patients hospitalized with acute respiratory infections: A meta-analysis

Abstract

This meta-analysis aimed to estimate the prevalence of human metapneumovirus (hMPV) infections in patients hospitalized for acute respiratory infection (ARI) and to study factors associated with this prevalence. Medline and ScienceDirect databases were searched for prospective observational studies that screened hospitalized patients with ARI for hMPV by RT-PCR, with data available at December 27, 2014. The risk of bias was assessed regarding participation rate, definition of ARI, description of diagnostic technique, method of inclusion identical for all subjects, standardized and identical sampling method for all subjects, analysis performed according to the relevant subgroups, and presentation of data sources. Random-effect meta-analysis with arcsine transformation and meta-regressions was used. In the 75 articles included, the prevalence of hMPV among hospitalized ARI was 6.24% (95% CI 5.25-7.30). An effect of the duration of the inclusion period was observed (p=0.0114), with a higher prevalence of hMPV in studies conducted during periods of 7-11 months (10.56%, 95% CI 5.97-16.27) or complete years (7.55%, 95% CI 5.90-9.38) than in periods of 6 months or less (5.36%, 95% CI 4.29-6.54). A significant increase in the incidence with increasing distance from the equator was observed (p=0.0384). hMPV should be taken into account as a possible etiology in hospitalized ARI.

Clinical characteristics and outcomes in adult patients hospitalized with influenza, respiratory syncytial virus and human metapneumovirus infections

“…Prior analyses have shown that influenza is the most common cause of ILI during the influenza season, accounting for 50-70% of such cases [22,23], whereas RSV and hMPV infections account for 3-6% of cases in previously healthy individuals [24,25]. In contrast, RSV and hMPV infections can be detected in 16-25% of hospitalized adults ≥ 65 years old with chronic medical conditions [26,27].…”

Prevalence of human respiratory syncytial virus infection in people with acute respiratory tract infections in Africa: A systematic review and meta‐analysis

“…Two investigators evaluated risk of bias in included studies using an eight‐item rating scale . These items included (a) participation response rate more than 75% agree to participate or analysis to show whether respondents and nonrespondents were similar for the sociodemographic characteristics; (b) ARTI clearly defined; (c) method of inclusion identical for all subjects; (d) description of diagnostic technique; (e) same type of sample collected for all patients (nasopharyngeal aspirate, nasal, or throat swab); (f) standardized method for sample collection (quantity of aspirate or of liquid used for the nasal wash with any virological medium transport for swabs); (g) analysis performed according to relevant subgroups (by age classes, by center, or by symptomatology, for example); and (h) and presentation of data sources (counts are presented, not only percentages).…”

Clinical characteristics and outcomes of adult patients hospitalized with influenza, respiratory syncytial virus and human metapneumovirus infections: a prospective, cohort study

“…Prior analyses have shown that in uenza is the most common cause of ILI during in uenza season, accounting for 50-70% of such cases [22][23], whereas RSV and hMPV infections account for 3-6% of cases in previously healthy individuals [24][25]. In contrast, RSV and hMPV infections can be detected in 16-25% of hospitalized adults ≥ 65 years old with chronic medical conditions [26][27].…”