Human Metapneumovirus in Lung Transplant Recipients and Comparison to Respiratory Syncytial Virus

Hopkins, Peter; McNeil, Keith; Kermeen, F.; Musk, M.; McQueen, Emily; Mackay, Ian M.; Sloots, T. P.; Nissen, Michael D.

doi:10.1164/rccm.200711-1657oc

Cited by 127 publications

(138 citation statements)

References 33 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…Given this, HMPV is responsible for many hospitalized cases (28,30,43,241), and infections in the elderly can result in death (28,30,43). Pneumonia has been documented for 40% of HMPV-infected frail elderly subjects (28,117,149). It has been reported that the most frequent admission diagnoses for HMPV infection in the elderly are acute bronchitis, COPD exacerbation, pneumonia, and congestive heart failure (241).…”

Section: Risk Groups Other Than Childrenmentioning

confidence: 99%

Human Metapneumovirus: Lessons Learned over the First Decade

Schildgen

Hoogen²,

Fouchier³

et al. 2011

Clin Microbiol Rev

181

187

View full text Add to dashboard Cite

SUMMARY It has been 10 years since human metapneumovirus (HMPV) was identified as a causative agent of respiratory illness in humans. Since then, numerous studies have contributed to a substantial body of knowledge on many aspects of HMPV. This review summarizes our current knowledge on HMPV, HMPV disease pathogenesis, and disease intervention strategies and identifies a number of areas with key questions to be addressed in the future.

show abstract

Section: Risk Groups Other Than Childrenmentioning

confidence: 99%

Human Metapneumovirus: Lessons Learned over the First Decade

Schildgen

Hoogen²,

Fouchier³

et al. 2011

Clin Microbiol Rev

181

187

View full text Add to dashboard Cite

show abstract

“…Infections can be acquired nosocomially or in the community. In lung transplant patients, RSV is associated with a higher risk of chronic rejection and bronchiolitis obliterans syndrome compared to hMPV [103]. In HIV-infected South African children, the incidence of hMPV and RSV hospitalisation has been shown to be 2.5 and 5.4 times higher, respectively, compared to HIVnegative children [104,105].…”

Section: Specific Populationsmentioning

confidence: 99%

The distinguishing features of human metapneumovirus and respiratory syncytial virus

Papenburg

Boivin

2010

Reviews in Medical Virology

View full text Add to dashboard Cite

Acute respiratory tract infections (RTIs) are a leading cause of morbidity and mortality worldwide. Human Metapneumovirus (hMPV) is a member of the Metapneumovirus genus within the Pneumovirinae subfamily of the Paramyxoviridae family. Though hMPV was only discovered in 2001, a large body of work has already shown that it is the aetiologic agent of a substantial proportion of upper and lower RTIs across all age groups in both healthy and immunocompromised hosts throughout the world. RSV, also a pneumovirus, is the human pathogen most closely related to hMPV. RSV is the leading cause of pneumonia and bronchiolitis in infants and young children, but can also cause respiratory tract disease in all age groups. In this paper, we will review the salient features of the virology, epidemiology, pathogenesis, host immune responses, clinical manifestations and diagnostic modalities of hMPV, using RSV as a comparison. In addition, we will show how immunoprophylactic and therapeutic strategies studied and used in clinical practice for RSV-some with great success, and others tragic failure-have led to promising areas of research for the prevention and treatment of the significant burden of disease caused by hMPV.

show abstract

“…Importantly, during the 2009 influenza A H1N1 pandemic, a significant number of cases of acute allograft injury due to influenza were observed (126)(127)(128). Severe cases of other CARVs, such as respiratory syncytial virus (RSV), parainfluenza virus and human metapneumovirus, have been described (129)(130)(131).…”

Section: Infection By Community-acquired Respiratory Virusesmentioning

confidence: 99%

The Impact of Infection on Chronic Allograft Dysfunction and Allograft Survival After Solid Organ Transplantation

Martín-Gandul

Mueller

Pascual

et al. 2015

American Journal of Transplantation

131

103

View full text Add to dashboard Cite

Infectious diseases after solid organ transplantation (SOT) are a significant cause of morbidity and reduced allograft and patient survival; however, the influence of infection on the development of chronic allograft dysfunction has not been completely delineated. Some viral infections appear to affect allograft function by both inducing direct tissue damage and immunologically related injury, including acute rejection. In particular, this has been observed for cytomegalovirus (CMV) infection in all SOT recipients and for BK virus infection in kidney transplant recipients, for community-acquired respiratory viruses in lung transplant recipients, and for hepatitis C virus in liver transplant recipients. The impact of bacterial and fungal infections is less clear, but bacterial urinary tract infections and respiratory tract colonization by Pseudomonas aeruginosa and Aspergillus spp appear to be correlated with higher rates of chronic allograft dysfunction in kidney and lung transplant recipients, respectively. Evidence supports the beneficial effects of the use of antiviral prophylaxis for CMV in improving allograft function and survival in SOT recipients. Nevertheless, there is still a need for prospective interventional trials assessing the potential effects of preventive and therapeutic strategies against bacterial and fungal infection for reducing or delaying the development of chronic allograft dysfunction.

show abstract

Human Metapneumovirus in Lung Transplant Recipients and Comparison to Respiratory Syncytial Virus

Cited by 127 publications

References 33 publications

Human Metapneumovirus: Lessons Learned over the First Decade

Human Metapneumovirus: Lessons Learned over the First Decade

The distinguishing features of human metapneumovirus and respiratory syncytial virus

The Impact of Infection on Chronic Allograft Dysfunction and Allograft Survival After Solid Organ Transplantation

Contact Info

Product

Resources

About