Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations

Samransamruajkit, Rujipat; Thanasugarn, Wanida; Prapphal, Nuanchan; Theamboonlers, Apiradee; Poovorawan, Yong

doi:10.1016/j.jinf.2005.07.001

Cited by 29 publications

(38 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results also show that pneumonia was the primary discharge diagnoses in hMPV positive cases followed by asthma and bronchiolitis. This finding is in agreement with data from a study done in Thailand which showed that pneumonia was the most common discharge diagnoses (50%) of hMPV positive cases followed by bronchiolitis (42%) . Thus showing hMPV can induce alterations in the airways leading to respiratory complications hence representing a public health problem for children worldwide …”

Section: Discussionsupporting

confidence: 91%

“…These findings are similar to the results obtained from a study done in Singapore which showed 67% hMPV detection rate in children less than 1 year of age . However, this is in contrast with the results obtained from a study done in Thailand, which found hMPV infection to be more common in the second year of life . Our study on RSV infection among children of the same age group found that RSV infection is more common in children less than 3 months of age as compared to hMPV (5).…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Human metapneumovirus in hospitalized children less than 5 years of age in Pakistan

Yousafzai

Ibrahim

Thobani

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

Acute respiratory infection (ARI) is the second leading cause of death in children less than 5 years of age worldwide. Human Metapneumovirus (hMPV) is associated with around 5-7% of the total pneumonia admissions in children. The aim of this study was to determine the magnitude of hMPV associated hospitalizations among children, in Karachi, Pakistan. A 3 years prospective study was conducted at the Aga Khan University Hospital (AKUH), from August 2009 to June 2012. Children less than 5 years of age, admitted with ARIs, were enrolled. Throat swabs were collected and tested for hMPV using real-time PCR. Multivariable log binomial regression analysis was performed. Out of 1150 children enrolled, hMPV was detected among 84/1150 (7%). About 87% of the enrolled children presented with cough, followed by fever (73%), nasal congestion (69%) and shortness of breath (68%). Of the hMPV positive subjects, most (56/84, 67%) were less than 12 months of age. The most common diagnosis in hMPV positive infants was pneumonia, followed by asthma and bronchiolitis. HMPV was identified year round, with peaks during February and August. Sore throat was found to be significantly associated with the hMPV infection (Adjusted RR 2.23; 95%CI 1.42-3.52). The proportion of hMPV was higher among hospitalized infants with ARI. Pneumonia was the primary discharge diagnoses of patients who tested positive for hMPV. hMPV could be a target for future vaccine to further decrease the burden of ARI morbidity and possibly mortality in developing countries.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

Human metapneumovirus in hospitalized children less than 5 years of age in Pakistan

Yousafzai

Ibrahim

Thobani

et al. 2018

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Respiratory virus detection rates of more than 50% can be achieved with molecular detection [15,16]. Other studies in tropical countries have reported that emerging respiratory viruses such as metapneumovirus (5.3-5.4%) [17,18], coronaviruses (0.6%) [19], bocavirus (8.0%) [19] and human rhinovirus C (12.8-30%) [20,21] also contribute substantially to morbidity.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years

et al. 2012

View full text Add to dashboard Cite

BackgroundViral respiratory tract infections (RTI) are relatively understudied in Southeast Asian tropical countries. In temperate countries, seasonal activity of respiratory viruses has been reported, particularly in association with temperature, while inconsistent correlation of respiratory viral activity with humidity and rain is found in tropical countries. A retrospective study was performed from 1982-2008 to investigate the viral etiology of children (≤ 5 years old) admitted with RTI in a tertiary hospital in Kuala Lumpur, Malaysia.MethodsA total of 10269 respiratory samples from all children ≤ 5 years old received at the hospital's diagnostic virology laboratory between 1982-2008 were included in the study. Immunofluorescence staining (for respiratory syncytial virus (RSV), influenza A and B, parainfluenza types 1-3, and adenovirus) and virus isolation were performed. The yearly hospitalization rates and annual patterns of laboratory-confirmed viral RTIs were determined. Univariate ANOVA was used to analyse the demographic parameters of cases. Multiple regression and Spearman's rank correlation were used to analyse the correlation between RSV cases and meteorological parameters.ResultsA total of 2708 cases were laboratory-confirmed using immunofluorescence assays and viral cultures, with the most commonly detected being RSV (1913, 70.6%), parainfluenza viruses (357, 13.2%), influenza viruses (297, 11.0%), and adenovirus (141, 5.2%). Children infected with RSV were significantly younger, and children infected with influenza viruses were significantly older. The four main viruses caused disease throughout the year, with a seasonal peak observed for RSV in September-December. Monthly RSV cases were directly correlated with rain days, and inversely correlated with relative humidity and temperature.ConclusionViral RTIs, particularly due to RSV, are commonly detected in respiratory samples from hospitalized children in Kuala Lumpur, Malaysia. As in temperate countries, RSV infection in tropical Malaysia also caused seasonal yearly epidemics, and this has implications for prophylaxis and vaccination programmes.

show abstract

“…The implications of this are unclear, but several reports note a correlation between severity of infection and the presence of the A genotype ( 12 , 13 ). Unfortunately, we were not able to make a strict comparison of our data with data from recent studies in Southeast Asia ( 14 , 15 ); these studies used significantly smaller sample sizes and a different selection criterion for the patients screened (i.e., LRTI [ 14 ] and wheezing and asthma [ 15 ]).…”

Section: The Studymentioning

confidence: 98%

Human Metapneumovirus in Children, Singapore

Loo

Tan

et al. 2007

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

Human metapneumovirus in infants and young children in Thailand with lower respiratory tract infections; molecular characteristics and clinical presentations

Cited by 29 publications

References 28 publications

Human metapneumovirus in hospitalized children less than 5 years of age in Pakistan

Human metapneumovirus in hospitalized children less than 5 years of age in Pakistan

Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years

Human Metapneumovirus in Children, Singapore

Contact Info

Product

Resources

About