Human Metapneumovirus (hMPV) in Acute Respiratory Infection: A Clinic-Based Study in Egypt

Yahia, Sohier; Kandeel, Amina; Hammad, Enas; El‐Gilany, Abdel‐Hady

doi:10.1007/s12098-011-0677-5

Cited by 16 publications

(15 citation statements)

References 30 publications

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“…This result was comparable to that of Chen, et al [24], Sohier Yahia, et al [16], and Cui Zhang, et al [25]. The higher incidence of hMPV infections among age group less than one year, might signify the importance of this age group as a risk factor for infection.…”

Section: Discussionsupporting

confidence: 83%

“…RT-PCR was highly sensitive and specific for the detection of hMPV, making it a valuable and a competitive technique with immunofluorescent assay for the detection of the virus. The frequency of hMPV infections highlighted by this study showed some variations with those that have emerged from previously published studies in different countries [11][12][13][14][15][16][17][18][19]. These variations in incidence among studies might reflect different epidemiological patterns of hMPV infections in different countries, which in turn might be related to environmental factors, geographical factors, differences in host genetic susceptibility, sampling techniques, detection methods, and/or different viral strains circulating in different geographical areas.…”

Section: Discussionmentioning

confidence: 43%

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Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infections in Sulaimani Province, Iraq

Aziz¹

2015

J Med Microb Diagn

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Background: Human Metapneumovirus (hMPV) is a member of Paramyxoviridae family. It is an important viral pathogen of respiratory tract infections among children. Therefore, the aim of this study is to determine the incidence of hMPV infections among children less than 5 years of age with respiratory tract infections at the pediatric hospital in Sulaimani city of Iraq. Also, this study aims to evaluate the different diagnostic methods for the detection of this virus.Method: Nasopharyngeal swabs and throat swabs were collected from 300 hospitalized children with respiratory infections under 5 years of age between April 2011 and March 2012. Each sample was used for hMPV detection by conventional reverse transcriptase (RT-PCR) and direct fluorescent assay (DFA). A questionnaire which was designed for acute respiratory tract infections among hospitalized children was also included. Results:Human Metapneumovirus was detected in 16% by RT-PCR and 14.7% by DFA. Autumn -winter period was the most common season for hMPV infections with its peak occurrence in January and February.Conclusions: hMPV is an important pathogen associated with RTIs in children. RT-PCR is highly sensitive and specific for the detection of hMPV than antigen detection methods used for the diagnosis of hMPV viruses.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 43%

Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infections in Sulaimani Province, Iraq

Aziz¹

2015

J Med Microb Diagn

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“…The infection ratio in the infants at the age of 7-12 mo (31 %) was more frequent than that of the 0-6 mo of children (19 %) in United States of America [6]. Yahia et al, [21] detected 8 % metapneumovirus in nasopharyngeal aspirates of 600 infants and children with respiratory infections. They also stated that the rate was significantly higher among children aged 2-24 mo compared to other age groups.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Common Viruses in Etiology of Acute Respiratory Tract Infections

et al. 2012

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“…These observations suggest that unknown pathogens may be responsible for a substantial proportion of respiratory tract diseases [6]. The impact on the severity of early life respiratory infections may be also affected by viral types diagnosed through sensitive polymerase chain reaction (PCR) analyses.…”

Section: Introductionmentioning

confidence: 99%

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

Othman

Elhamed

Hassan

et al. 2016

J Infect Dev Ctries

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Introduction: Viruses are the most important causative agents of acute lower respiratory tract infections (ALRTIs), ranked as the second leading cause of death and the primary cause of hospitalization in children. Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are among the commonest viral causes of severe ALRTI. In this study, we aimed to study the burden of both RSV and hMPV in causing severe ALRTI in children younger than two years of age admitted to the pediatric intensive care unit (PICU). Methodology: Nasopharyngeal swabs were collected from children admitted to the PICU with a diagnosis of community-acquired ALRTI who were two years of age or younger. Real-time polymerase chain reaction (RT-PCR) was used to test for RSV and hMPV. Results: A total of 127 swabs were screened for RSV and hMPV, of which 49.6% were negative for RSV and hMPV, 46.4% were positive for RSV, and 3.9% were positive for hMPV. With respect to RSV, the mean age of cases (4.01 ± 5.05) and the monthly distribution (mainly January) were the most important risk factors. There were no statistically significant differences between the RSV group and control group regarding duration of hospital stay, mechanical ventilation need or duration, and underlying chronic conditions. Conclusions: RSV is important viral cause of severe ALRTIs in children younger than two years of age during this study period; hMPV played a minor role.

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Human Metapneumovirus (hMPV) in Acute Respiratory Infection: A Clinic-Based Study in Egypt

Abstract: hMPV is an emerging cause of acute respiratory infection in Mansoura University Children Hospital (MUCH), and may have a significant clinical impact on infants and children and thus, must be considered in etiological diagnosis.

Cited by 16 publications

References 30 publications

Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infections in Sulaimani Province, Iraq

Detection of Human Metapneumovirus in Hospitalized Children with Acute Respiratory Tract Infections in Sulaimani Province, Iraq

Frequency of Common Viruses in Etiology of Acute Respiratory Tract Infections

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

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