Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5

García-García, M.L.; Calvo, Cristina; Casas, Inmaculada; Bracamonte, Teresa; Rellán, A.; Gozalo, F.; Tenorio, T.; Pérez-Breña, Pilar

doi:10.1002/ppul.20597

Cited by 122 publications

(101 citation statements)

References 46 publications

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“…The strong association between hMPV infection and asthma in both children (Garcia-Garcia et al, 2007;Peiris et al, 2003) and adults (Williams et al, 2005), and the ability of hMPV infection to exacerbate hRSV disease (Bosis et al, 2005;Semple et al, 2005), illustrate the need to improve our understanding of hMPV-induced T-cell immunity, particularly as a prelude to therapeutic intervention. As hMPV can establish productive infection in the upper and lower respiratory tract (Alvarez et al, 2004;Hamelin et al, 2005;van den Hoogen et al, 2001), hMPV-expressed proteins have the potential to function as targets of CD8 + CTL responses.…”

Section: Discussionmentioning

confidence: 99%

“…Young children, the elderly and immunocompromised individuals are particularly susceptible to hMPV-associated disease, emphasizing the need to understand the role of antiviral immunity in the control of infection. Several studies have indicated a strong association between hMPV disease and asthma in both children (Garcia-Garcia et al, 2007;Peiris et al, 2003;Tauro et al, 2008) and adults (Williams et al, 2005), implicating hMPV in ongoing or long-term adverse effects.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus

Herd

Nelson

Mahalingam

et al. 2010

Journal of General Virology

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Human metapneumovirus (hMPV) is a major cause of upper and lower respiratory-tract infection in infants, the elderly and immunocompromised individuals. Virus-directed cellular immunity elicited by hMPV infection is poorly understood, in contrast to the phylogenetically and clinically related pathogen human respiratory syncytial virus (hRSV). In a murine model of acute lower respiratorytract infection with hMPV, we demonstrate the accumulation of gamma interferon (IFN-c)-producing CD8+ T cells in the airways and lungs at day 7 post-infection (p.i.), associated with cytotoxic T lymphocytes (CTLs) directed to an epitope of the M2-1 protein. This CTL immunity was accompanied by increased pulmonary expression of Th1 cytokines IFN-c and interleukin (IL)-12 and antiviral cytokines (IFN-b), as well as chemokines Mip-1a, Mip-1b, Mig, IP-10 and CX3CL1. There was also a moderate increase in Th2-type cytokines IL-4 and IL-10 compared with uninfected mice. At 21 days p.i., a strong CTL response could be recalled from the spleen. A similar pattern of CTL induction to the homologous M2-1 CTL epitope of hRSV, and of cytokine/ chemokine induction, was observed following infection with hRSV, highlighting similarities in the cellular immune response to the two related pathogens.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus

Herd

Nelson

Mahalingam

et al. 2010

Journal of General Virology

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“…Measurements of cytokines implicated in asthma pathogenesis in nasal washes of HMPV-infected infants have yielded conflicting results (119,133). One retrospective study found a strong association between HMPV infection during infancy and the subsequent diagnosis of asthma (86). A major challenge for studies of respiratory viruses and asthma is the difficulty in firmly establishing a diagnosis of asthma during infancy, when acute wheezing associated with viral infections is common.…”

Section: Symptoms and Pathologymentioning

confidence: 99%

Human Metapneumovirus: Lessons Learned over the First Decade

Schildgen

Hoogen²,

Fouchier³

et al. 2011

Clin Microbiol Rev

181

187

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SUMMARY It has been 10 years since human metapneumovirus (HMPV) was identified as a causative agent of respiratory illness in humans. Since then, numerous studies have contributed to a substantial body of knowledge on many aspects of HMPV. This review summarizes our current knowledge on HMPV, HMPV disease pathogenesis, and disease intervention strategies and identifies a number of areas with key questions to be addressed in the future.

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“…Previously, RSV and human metapneumovirus (HMPV) have been implicated as major aetiological agents for LRI [7,8], but human rhinoviruses (HRVs) are gaining recognition as significant LRI pathogens [9][10][11][12][13]. Infants hospitalised for HRV-induced wheezing in infancy were found to have increased risk of asthma at 6 yrs in one of the first studies to report HRVs as inducers of early childhood wheezing [9].…”

mentioning

confidence: 99%

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

Kusel

Kebadze²,

Johnston³

et al. 2011

Eur Respir J

107

145

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Severe viral respiratory illnesses and atopy are risk factors for childhood wheezing and asthma. The aim of this study was to explore associations between severe respiratory infections and atopy in early childhood with wheeze and asthma persisting into later childhood.147 children at high atopic risk were followed from birth to age 10 yrs. Data on all respiratory infections occurring in infancy were collected prospectively and viral aetiology ascertained. Atopy was measured by skin prick tests at 6 months, and 2 and 5 yrs. History of wheeze and doctordiagnosed eczema and asthma was collected regularly until 10 yrs of age.At 10 yrs, 60% of the cohort was atopic, 25.9% had current eczema, 18.4% current asthma and 20.4% persistent wheeze. 35.8% experienced at least one lower respiratory infection (LRI) associated with fever and/or wheeze in first year of life. Children who had wheezy or, in particular, febrile LRI in infancy and were atopic by 2 yrs, were significantly more likely to have persistent wheeze (RR 3.51, 95% CI 1.83-6.70; p,0.001) and current asthma (RR 4.92, 95% CI 2.59-9.36; p,0.001) at 10 yrs.Severe viral respiratory infections in infancy and early atopy are risk factors for persistent wheeze and asthma. The strongest marker of the asthmatogenic potential of early life infections was concurrent fever. The occurrence of fever during respiratory illnesses is an important marker of risk for wheeze and asthma later in childhood, suggesting it should be measured in prospective studies of asthma aetiology.

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Human metapneumovirus bronchiolitis in infancy is an important risk factor for asthma at age 5

Abstract: hMPV-bronchiolitis in infancy was strongly associated with asthma as well as other forms of bronchial obstructive disease at third and fifth year of life. This association is, at least, as strong as the association observed with RSV infections.

Cited by 122 publications

References 46 publications

Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus

Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus

Human Metapneumovirus: Lessons Learned over the First Decade

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

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