Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study

Czank, Charles; Cassidy, Aedín; Zhang, Qingzhi; Morrison, Douglas J.; Preston, Tom; Kroon, Paul A.; Botting, Nigel P.; Kay, Colin D.

doi:10.3945/ajcn.112.049247

Cited by 494 publications

(601 citation statements)

References 42 publications

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“…However, a study in humans using 13C 5 -labeled anthocyanin showed that the relative bioavailability was 12.3861.38% (17). Furthermore, anthocyanins can be absorbed into the circulation in their intact form in small amounts, while substantial amounts of anthocyanins enter the colon and undergo extensive metabolic transformation by the gut microbiota, producing a wide range of aromatic and phenolic compounds (33).…”

Section: Discussionmentioning

confidence: 99%

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

ZHOU

Deng

Chen

et al. 2017

J Nutr Sci Vitaminol

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Summary Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-b1 in gel-filtered platelets, in addition to attenuating serum PF4 and b-TG levels in mice fed high-fat diets. These results provide evidence that Cy-3-g protects against thrombosis and CVDs by inhibiting purified platelet granule release in vivo.

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Section: Discussionmentioning

confidence: 99%

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

ZHOU

Deng

Chen

et al. 2017

J Nutr Sci Vitaminol

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“…Literature shows that the relative bioavailability of cyanidin-3-glucoside was 12.38 ± 1.38%, where 5.37 ± 0.67% was excreted in urine and 6.91 ± 1.59% in the breath within 48 h after oral ingestion [68]. The reported metabolites of cyanidin-3-glucoside after digestion by the human body are phenolic acid, and phenolic conjugates, hippuric, phenylacetic, and phenylpropenoic acids.…”

Section: Nutraceutical and Pharmaceutical Effects Of Anthocyaninsmentioning

confidence: 99%

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Khoo

Azlan

Tang

et al. 2017

Food & Nutrition Research

1,793

1,327

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Anthocyanins are colored water-soluble pigments belonging to the phenolic group. The pigments are in glycosylated forms. Anthocyanins responsible for the colors, red, purple, and blue, are in fruits and vegetables. Berries, currants, grapes, and some tropical fruits have high anthocyanins content. Red to purplish blue-colored leafy vegetables, grains, roots, and tubers are the edible vegetables that contain a high level of anthocyanins. Among the anthocyanin pigments, cyanidin-3-glucoside is the major anthocyanin found in most of the plants. The colored anthocyanin pigments have been traditionally used as a natural food colorant. The color and stability of these pigments are influenced by pH, light, temperature, and structure. In acidic condition, anthocyanins appear as red but turn blue when the pH increases. Chromatography has been largely applied in extraction, separation, and quantification of anthocyanins. Besides the use of anthocyanidins and anthocyanins as natural dyes, these colored pigments are potential pharmaceutical ingredients that give various beneficial health effects. Scientific studies, such as cell culture studies, animal models, and human clinical trials, show that anthocyanidins and anthocyanins possess antioxidative and antimicrobial activities, improve visual and neurological health, and protect against various non-communicable diseases. These studies confer the health effects of anthocyanidins and anthocyanins, which are due to their potent antioxidant properties. Different mechanisms and pathways are involved in the protective effects, including free-radical scavenging pathway, cyclooxygenase pathway, mitogen-activated protein kinase pathway, and inflammatory cytokines signaling. Therefore, this review focuses on the role of anthocyanidins and anthocyanins as natural food colorants and their nutraceutical properties for health. Abbreviations: CVD: Cardiovascular disease VEGF: Vascular endothelial growth factor

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“…[45]. For the anthocyanin, cyanidin-3-glucoside, which is the main anthocyanin in QGP juice [36,46], the half-life has been shown to range between 12 and 51h [47].…”

Section: Subject Characteristicsmentioning

confidence: 99%

Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

et al. 2017

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Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study

Abstract: Anthocyanins are more bioavailable than previously perceived, and their metabolites are present in the circulation for ≤48 h after ingestion. This trial was registered at clinicaltrials.gov as NCT01106729.

Cited by 494 publications

References 42 publications

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

Anthocyanin Cyanidin-3-Glucoside Attenuates Platelet Granule Release in Mice Fed High-Fat Diets

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

Anthocyanin-rich plum juice reduces ambulatory blood pressure but not acute cognitive function in younger and older adults: a pilot crossover dose-timing study

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