2012
DOI: 10.1152/ajplung.00180.2011
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Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes

Abstract: MA. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Am

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Cited by 285 publications
(299 citation statements)
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References 41 publications
(72 reference statements)
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“…MSCs were able to increase the proportion of phagocytic MDMs in the presence of LPS ( Figure 1D). This adds to the body of literature supporting the phagocytosis-enhancing effects of MSCs on both macrophages and monocytes (8,10,19,27).…”
Section: Msc-derived Ev-treated Murine Amsmentioning
confidence: 63%
See 1 more Smart Citation
“…MSCs were able to increase the proportion of phagocytic MDMs in the presence of LPS ( Figure 1D). This adds to the body of literature supporting the phagocytosis-enhancing effects of MSCs on both macrophages and monocytes (8,10,19,27).…”
Section: Msc-derived Ev-treated Murine Amsmentioning
confidence: 63%
“…Mesenchymal stromal cells (MSCs) are increasingly recognized as a promising candidate therapy for ARDS (6). We and others have reported that MSCs improve survival, reduce inflammation, and enhance bacterial clearance in preclinical models of lung injury (7)(8)(9)(10)(11)(12)(13)(14). Secretion of paracrine factors, modulation of host cells via secretion of extracellular vesicles (EVs), and mitochondrial transfer were shown to be important for the therapeutic effects of MSCs in these studies.…”
mentioning
confidence: 90%
“…37,38,[48][49][50][51] This antibacterial eff ect is partly mediated by improved phagocytic activity of host immune cells such as macrophages, 38,41 monocytes, 48 neutrophils, 49 and ITGAMpositive cells (monocytes, macrophages, and neutrophils). 38 Studies using ex-vivo human lungs have reported similar fi ndings.…”
Section: Antimicrobial Eff Ectsmentioning
confidence: 99%
“…Como placebo se utilizó una inyección de fibroblastos, suero salino o MSC inactivados por shock térmico. El tratamiento de soporte consistió en antibióticos y volumen, los que fueron administrados a los grupos experimental y placebo [24][25][26][27][28][29] . El momento de la infusión y la dosis de MSCs fue variable entre los estudios.…”
Section: Sepsisunclassified