Human memory T cells: generation, compartmentalization and homeostasis

Farber, Donna L.; Yudanin, Naomi; Restifo, Nicholas P.

doi:10.1038/nri3567

Cited by 724 publications

(691 citation statements)

References 152 publications

(151 reference statements)

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“…These events are also mediated by TCR engagement and high ZAP-70 tyrosine kinase expression levels. There are encouraging results on the role of IFN-γ in Ci8-mediated mechanisms especially by CD4 + memory T lymphocytes and this in agreement with Farber et al (Farber, 2014) who demonstrated that the T EM subset has the highest proportion IFN-γ producing cells. Effector T cell stimulation by specific antigens leads to an array of functional events optimally tailored to provide an appropriate immune response that includes T cell selection, proliferation and cytokine production by antigen specific T cells.…”

Section: Discussionsupporting

confidence: 78%

“…The TCR-driven pathways that lead to proliferation appear separable to the secretion of cytokines, another event that by immune cells defines a significant part of their functional activity (Guy et al, 2013). Our hypothesis is that Ci8 short cytokines production is mediated by Effector Memory T cells (T EM ) (Farber, 2014) that can produce these immediately after antigen challenge with a rapid recall mechanism (Scheffold et al, 2000;Han et al, 2012;Campbell et al, 2010). These events are also mediated by TCR engagement and high ZAP-70 tyrosine kinase expression levels.…”

Section: Discussionmentioning

confidence: 99%

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Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis, modulates responses of the human immune system

et al. 2018

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis, modulates responses of the human immune system

et al. 2018

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“…Based on differential expression of surface markers the following B-cell subsets were identified: immature/ /early-transitional (I/T, CD27-IgD+CD21 low ), late-transitional/naïve (CD27-IgD+CD21+), non-switched memory (NSM, CD27+IgD+), resting class-switched memory (SM, CD27+IgD-CD21+), activated SM (CD27+IgD-CD21 low ), and double-negative (CD27-IgD-) exhausted memory (ExM) as summarized in Figure 1C [8,16,23,25]. Using T-cell panel we identified four subsets within CD4+ or CD8+ gate: naïve (CD45RA+CD45RO-CCR7+), central memory (T CM , CD45RA-CD45RO+CCR7+), effector memory (T EM , CD45RA-CD45RO+CCR7-), and effector memory CD45RA+ (T EMRA , CD45RA+CD45RO-CCR7-) [26,27].…”

Section: Methodsmentioning

confidence: 99%

Changes of memory B- and T-cell subsets in lupus nephritis patients

Kosałka

Jakieła

Musiał

2015

Folia Histochem Cytobiol.

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Introduction. Renal involvement in systemic lupus erythematosus (SLE) is associated with production of antibodies to double stranded DNA, deposition of immune complexes and organ damage. These processes have been linked with abnormalities in B-and T-cell memory compartments. The aim of the study was to analyze subsets of peripheral memory B-cells and T-cells in lupus nephritis (LN) patients. Material and methods. We used multicolor flow cytometry to analyze major memory subsets of peripheral blood B-cells (defined by CD27, IgD and CD21) and T-cells (CD45RA, CD45RO, CCR7) in 32 patients with active or inactive LN, and 23 control subjects. Results. Lupus nephritis patients were characterized by increased percentage of immature/early-transitional B-cells (CD27-IgD+CD21-), higher frequency of activated switched memory (SM, CD27+IgD-CD21-) and exhausted memory B-cells (CD27-IgD-), and decrease in non-switched memory (NSM, CD27+IgD+) B-cells. CD21 low subsets (immature and activated B-cells) were particularly expanded in patients with active disease. In both groups of LN patients we observed decline in the absolute count of NSM B-cells. It was paralleled by lymphopenia in naïve CD4+ T-cell compartment and increase in the frequency of effector memory T-cells, and these changes were more pronounced in active LN. Conclusions. B-cell memory compartment in LN is deficient in NSM cells and during active disease it is further skewed towards SM and exhausted memory phenotypes, most likely as a cause of chronic antigenic stimulation. Parallel changes in T-helper cell subsets suggest a similar mechanism of SLE-related lymphopenia for both B-cell and T-cell compartment.

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“…Memory T cells display the exquisite Correspondence: Dr. Paul Zajac e-mail: paul.zajac@usb.ch ability to respond to previously experienced antigens with clonal expansion and with the rapid elicitation of multiple effector function [1]. However, the origin of memory CD8 + T cells is still debated, particularly concerning the relationship between effector and memory cells [2].…”

Section: Introductionmentioning

confidence: 99%

CD40 ligand‐expressing recombinant vaccinia virus promotes the generation of CD8⁺ central memory T cells

et al. 2015

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Central memory CD8 + T cells (T CM ) play key roles in the protective immunity against infectious agents, cancer immunotherapy, and adoptive treatments of malignant and viral diseases. CD8+ T CM cells are characterized by specific phenotypes, homing, and proliferative capacities. However, CD8 + T CM -cell generation is challenging, and usually requires CD4 + CD40L + T-cell "help" during the priming of naïve CD8 + T cells. We have generated a replication incompetent CD40 ligand-expressing recombinant vaccinia virus (rVV40L) to promote the differentiation of human naïve CD8 + T cells into T CM specific for viral and tumor-associated antigens. Soluble CD40 ligand recombinant protein (sCD40L), and vaccinia virus wild-type (VV WT), alone or in combination, were used as controls. Here, we show that, in the absence of CD4 + T cells, a single "in vitro" stimulation of naïve CD8 + T cells by rVV40L-infected nonprofessional CD14 + antigen presenting cells promotes the rapid generation of viral or tumor associated antigen-specific CD8 + T cells displaying T CM phenotypic and functional properties. These observations demonstrate the high ability of rVV40L to fine tune CD8 + mediated immune responses, and strongly support the use of similar reagents for clinical immunization and adoptive immunotherapy purposes.Keywords: Antigen presenting cells r Central memory T cells r CD40-CD40L r CD4 + T cells r CD8 + T cells r Immunological memory r Vaccinia virus Additional supporting information may be found in the online version of this article at the publisher's web-site IntroductionGeneration of immunological memory represents a key tenet of the adaptive immune system. Memory T cells display the exquisite Correspondence: Dr. Paul Zajac e-mail: paul.zajac@usb.ch ability to respond to previously experienced antigens with clonal expansion and with the rapid elicitation of multiple effector function [1]. However, the origin of memory CD8 + T cells is still debated, particularly concerning the relationship between effector and memory cells [2].Current understanding is consistent with the "one cell, multiple fates" model postulating that memory and effector T cells C 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.eji-journal.eu Eur. J. Immunol. 2016. 46: 420-431 Immunomodulation 421 may arise from single naïve CD8 + T-cell precursor undergoing asymmetric division originating two daughter cells with different cell fates [3]. Alternatively, a linear differentiation model proposes that memory CD8 + T lymphocytes may derive from effector cells surviving the contraction phase of the primary immune response [4]. Memory compartment encompasses lymphocyte subpopulations characterized by different phenotypes, functional properties, and anatomic locations. Two main subsets, central (T CM ) and effector memory (T EM ) lymphocytes, displaying a differential expression of homing and chemokine receptors have consistently been identified [5,6].Notably, T CM are characterized by high proliferative potential in response to antigen stimulation and...

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Human memory T cells: generation, compartmentalization and homeostasis

Cited by 724 publications

References 152 publications

Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis, modulates responses of the human immune system

Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis, modulates responses of the human immune system

Changes of memory B- and T-cell subsets in lupus nephritis patients

CD40 ligand‐expressing recombinant vaccinia virus promotes the generation of CD8⁺ central memory T cells

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Human memory T cells: generation, compartmentalization and homeostasis

Cited by 724 publications

References 152 publications

Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis, modulates responses of the human immune system

Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis, modulates responses of the human immune system

Changes of memory B- and T-cell subsets in lupus nephritis patients

CD40 ligand‐expressing recombinant vaccinia virus promotes the generation of CD8+ central memory T cells

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CD40 ligand‐expressing recombinant vaccinia virus promotes the generation of CD8⁺ central memory T cells