Human Memory Retrieval and Inhibitory Control in the Brain: Beyond Correlational Evidence

Penolazzi, Barbara; Stramaccia, Davide Francesco; Braga, Miriam; Mondini, Sara; Galfano, Giovanni

doi:10.1523/jneurosci.0349-14.2014

Cited by 75 publications

(57 citation statements)

References 32 publications

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“…This result is consistent with our previous fMRI study (Khader et al, 2011) and other studies that have found a link between the DLPFC and retrieval control (see, e.g., Penolazzi, Stramaccia, Braga, Mondini, & Galfano, 2014;Jaeger, Selmeczy, O'Connor, Diaz, & Dobbins, 2012;Wheeler & Buckner, 2003). However, it should be noted that numerous studies have also highlighted a possible role of the ventrolateral pFC ( VLPFC; encompassing BA 45/47) for this function (see, e.g., Barredo, Öztekin, & Badre, 2013;Badre & Wagner, 2007).…”

Section: Additional Analysessupporting

confidence: 93%

Neural Signatures of Controlled and Automatic Retrieval Processes in Memory-based Decision-making

Khader

Pachur

Weber

et al. 2016

Journal of Cognitive Neuroscience

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Decision-making often requires retrieval from memory. Drawing on the neural ACT-R theory [Anderson, J. R., Fincham, J. M., Qin, Y., Stocco, A. A central circuit of the mind. Trends in Cognitive Sciences, 12, 136-143, 2008] and other neural models of memory, we delineated the neural signatures of two fundamental retrieval aspects during decision-making: automatic and controlled activation of memory representations. To disentangle these processes, we combined a paradigm developed to examine neural correlates of selective and sequential memory retrieval in decision-making with a manipulation of associative fan (i.e., the decision options were associated with one, two, or three attributes). The results show that both the automatic activation of all attributes associated with a decision option and the controlled sequential retrieval of specific attributes can be traced in material-specific brain areas. Moreover, the two facets of memory retrieval were associated with distinct activation patterns within the frontoparietal network: The dorsolateral prefrontal cortex was found to reflect increasing retrieval effort during both automatic and controlled activation of attributes. In contrast, the superior parietal cortex only responded to controlled retrieval, arguably reflecting the sequential updating of attribute information in working memory. This dissociation in activation pattern is consistent with ACT-R and constitutes an important step toward a neural model of the retrieval dynamics involved in memory-based decision-making. , 12, 136-143, 2008] and other neural models of memory, we delineated the neural signatures of two fundamental retrieval aspects during decision-making: automatic and controlled activation of memory representations. To disentangle these processes, we combined a paradigm developed to examine neural correlates of selective and sequential memory retrieval in decision-making with a manipulation of associative fan (i.e., the decision options were associated with one, two, or three attributes). The results show that both the automatic activation of all attributes associated with a decision option and the controlled sequential retrieval of specific attributes can be traced in materialspecific brain areas. Moreover, the two facets of memory retrieval were associated with distinct activation patterns within the frontoparietal network: The dorsolateral prefrontal cortex was found to reflect increasing retrieval effort during both automatic and controlled activation of attributes. In contrast, the superior parietal cortex only responded to controlled retrieval, arguably reflecting the sequential updating of attribute information in working memory. This dissociation in activation pattern is consistent with ACT-R and constitutes an important step toward a neural model of the retrieval dynamics involved in memory-based decision-making. ■

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Section: Additional Analysessupporting

confidence: 93%

Neural Signatures of Controlled and Automatic Retrieval Processes in Memory-based Decision-making

Khader

Pachur

Weber

et al. 2016

Journal of Cognitive Neuroscience

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“…It may be that the comparison of words and nonwords appears to be better explained by nuances of the inhibitory framework, which either consider that inhibitory functions rely predominantly on the role of inhibitory synapses (Loftus et al, ; Penolazzi et al, ) or that inhibitory functions rely on the right balance between inhibitory and excitatory synapses (Jackson et al, ; Krause et al, ). Our results for LD would seem to support the first nuance.…”

Section: Discussionmentioning

confidence: 99%

“…One can understand this as an effect of an induced increase in inhibitory activity. Penolazzi, Stramaccia, Braga, Mondini, and Galfano (), in turn, reported suppression of the retrieval‐induced forgetting (RIF) phenomenon caused by cathodal tDCS of the right DLPFC, assumed to be a result of an induced decrease in inhibition. However, in cases where pathological increased inhibition is observed, the downregulation induced by cathodal stimulation has been considered to be beneficial (e.g., Monti et al, ).…”

Section: Introductionmentioning

confidence: 99%

Task load modulates tDCS effects on language performance

Almeida

Pope

Hansen

2019

J of Neuroscience Research

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Transcranial direct current stimulation (tDCS) effects in cognition are inconsistent across studies. This study aimed to discuss why typical models might be insufficient to explain these effects, and to investigate a brain state factor, task load, with behavioral experiments on phonological processing. The motor theory of speech perception states that motor codes for articulation take part in speech perception, a view sharpened by neuroimaging findings, which show that the motor role in phonological processing is weighted by the nature of the tasks. Three groups of 20 participants, each under a different tDCS condition (anodal, cathodal, or sham), performed a categorical perception (CP), a lexical decision (LD), and a word naming (WN) task while stimulated on the pars opercularis of the left inferior frontal gyrus, a language area typically involved with the motor role. These tasks were assumed to be subserved by a network of nodes which included the target, believed to be increasingly relevant for performance from speech perception to speech production. A-tDCS facilitation and C-tDCS downregulation should directly increase with the relevance of the target for the task. Downregulation of a low relevance node could result in facilitation by compensation from other nodes. Overall, our brain stimulation findings support the neuroimaging literature in that motor participation in phonological processing depends on task nature and show that tDCS effects are modulated by task load relative to the target. Outcomes such as the improved performance following cathodal tDCS in CP and WN suggest that compensatory mechanisms may take place when the tasks involve more complex neuronal networks. K E Y W O R D Scognition, language, pars opercularis of the left inferior frontal gyrus (LIFGop), phonological processing, task load, transcranial direct current stimulation (tDCS) | 1431 RODRIGUES DE ALMEIDA Et AL.

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“…As regards the methodological implications, we were able to corroborate previous findings on IB with a different brain stimulation technique, which is usually described as having a lower spatial resolution than TMS. Similar results obtained with tDCS allow enlargement of the domain of application of the technique itself, which has already also been shown to be a fruitful tool for experimental research in different domains (Penolazzi et al ., , , ; Foerster et al ., ; Leow et al ., ). As regards the theoretical implications, we extended the findings of Moore et al .…”

Section: Discussionmentioning

confidence: 99%

Neural underpinnings of the ‘agent brain’: new evidence from transcranial direct current stimulation

Cavazzana

Penolazzi

Begliomini

et al. 2015

Eur J of Neuroscience

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Intentional binding (IB) refers to the temporal compression between a voluntary action and its sensory effect, and it is considered an implicit measure of sense of agency (SoA), that is, the capacity to control one's own actions. IB has been thoroughly studied from a behavioural point of view but only few studies have investigated its neural underpinnings, always using the same two paradigms. Although providing evidence that the supplementary motor complex is involved, findings are still too scarce to draw definitive conclusions. The aim of the present study was to establish a causal relationship between the pre-supplementary motor area (pre-SMA), known for its key role in action planning and initiation, and IB by means of transcranial direct current stimulation (tDCS). Participants underwent anodal, cathodal and sham control stimulations during three separate sessions (Experiment I). Subsequently, they underwent the same stimulation protocol (Experiment II) using as control a region potentially involved in the processing of the sensory effects of voluntary action (i.e., the right primary auditory cortex for the auditory effects of action). A significant reduction in IB was found only after stimulation of the pre-SMA, which supports the causal contribution of this prefrontal area in the perceived linkage between action and its effects. As SoA could be disrupted in many psychiatric and neurological diseases, these results have direct clinical relevance as tDCS could be successfully used in this domain in virtue of the promising advantages it offers for rehabilitation.

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Human Memory Retrieval and Inhibitory Control in the Brain: Beyond Correlational Evidence

Cited by 75 publications

References 32 publications

Neural Signatures of Controlled and Automatic Retrieval Processes in Memory-based Decision-making

Neural Signatures of Controlled and Automatic Retrieval Processes in Memory-based Decision-making

Task load modulates tDCS effects on language performance

Neural underpinnings of the ‘agent brain’: new evidence from transcranial direct current stimulation

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