Human lymphocytes express substance P and its receptor

Lai, Jianping; Douglas, Steven D.; Ho, Wen‐Zhe

doi:10.1016/s0165-5728(98)00025-3

Cited by 240 publications

(207 citation statements)

References 34 publications

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“…SP autocrine regulation in monocytederived macrophages (MDM) is further supported by the presence of specific cell membrane SP receptors (13) and production of SP protein by macrophages (8,9,(14)(15)(16)(17). SP mRNA and protein are present in monocyte͞macrophages and lymphocytes isolated from human peripheral blood (16,18). We have also identified the presence of neurokinin-1 receptor (NK-1R) mRNA in these cells (16,18).…”

mentioning

confidence: 91%

“…SP mRNA and protein are present in monocyte͞macrophages and lymphocytes isolated from human peripheral blood (16,18). We have also identified the presence of neurokinin-1 receptor (NK-1R) mRNA in these cells (16,18). Because SP is secreted by human monocyte͞macrophages and participates in immunoregulation in an autocrine fashion (8,9,14,16,19), it may have a role in the pathogenesis of immune-mediated diseases, including neuroimmunologic diseases and HIV͞AIDS.…”

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confidence: 99%

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Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes

Lai

Zhan

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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confidence: 91%

mentioning

confidence: 99%

Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes

Lai

Zhan

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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“…The human NK-1R gene (14)(15)(16)(17), localized to chromosome 2, has been cloned. NK-1R has been identified on immune cells (1,12,(18)(19)(20)(21)(22), including T and B lymphocytes (19,23,24), monocytes͞macrophages (18,25), neutrophils (26), and mast cells (27). In a mouse model, gene-targeted disruption of NK-1R protected the lung from immune complex injury, demonstrating that SP amplifies the inflammatory reaction through binding to NK-1R (28).…”

mentioning

confidence: 99%

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation

Lai

Kilpatrick

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

102

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“…Known SP effects range from increasing inflammatory cytokine mRNA expression and secretion (26) to stimulating angiogenesis (27) and proliferation of fibroblasts (28). Neurons are the primary source of SP, but lymphocytes (29), monocytes (30), macrophages (30), and eosinophils (31) have been identified as additional sources. SP is present in peritoneal fluid (32), and SP-containing sensory neurons have been found in peritoneal adhesions (33).…”

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confidence: 99%

A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity

Reed

Fruin

Gower

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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Fibrous adhesions remain a major sequela of abdominal surgery. The proinflammatory peptide substance P (SP), known to participate in inflammatory events, may play a key role in adhesion formation. This hypothesis was tested by using an antagonist, CJ-12,255 (Pfizer), that blocks the binding of SP to the neurokinin 1 receptor (NK-1R). Adhesion formation was surgically induced in the peritoneum of rats receiving daily doses of the NK-1R antagonist (NK-1RA; 5.0 or 10.0 mg͞kg per day) or saline. On postoperative day 7, both the low and high doses of NK-1RA significantly (P < 0.05) reduced adhesion formation by 45% and 53%, respectively, compared with controls. Subsequently, the effect of NK-1RA administration on peritoneal fibrinolytic activity was investigated to determine a potential mechanism for SP action in the peritoneum. Samples were collected from nonoperated controls and from animals 24 h postsurgery that were administered either NK-1RA or saline. Fibrinolytic activity in peritoneal fluid was assayed by zymography, and expression of tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1, both regulators of fibrinolytic activity, was assessed in peritoneal tissue and fluid by RT-PCR and bioassay, respectively. NK-1RA administration led to a marked (P < 0.05) increase in tPA mRNA levels in peritoneal tissue compared with nonoperated and saline-administered animals. Likewise, NK-1RA administration significantly (P < 0.05) increased tPA in the peritoneal fluid. These data suggest that activation of the NK-1R promotes peritoneal adhesion formation by limiting fibrinolytic activity in the postoperative peritoneum, thus enabling fibrinous adhesions to persist.

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Human lymphocytes express substance P and its receptor

Cited by 240 publications

References 34 publications

Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes

Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes

Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation

A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity

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