Human lymphocytes: 5'-nucleotidase-positive and -negative subpopulations.

Evaluation of 5?-nucleotidase as biochemical marker in leukemias and lymphomas

“…However, very low values were measured for all eleven patients with CLL of B-type without exception. This characteristic decrease in enzyme activity was also observed by Silber et al (1975). A similar decrease of 5'-N like in B-CLL was also recorded for patients with hairy cell leukemia (HCL).…”

“…1979;Rowe etal. 1979; Thompson et al 1979), in chronic lymphocytic leukemia (Silber et al 1975;Kanter et al 1979) and in E-rosette positive forms of acute lymphocytic leukemia (ALL) (Reaman et al 1979). In a recent investigation we could show the high diagnostic value of 5'-N in the distinction of myeloid and lymphoid blast crisis in CML (Gutensohn et al 1980b especially when tested together with the common ALL antigen (cALLA).…”

Synthesis of DNA and Poly(Adenosine Diphosphate Ribose) in Normal and Chronic Lymphocytic Leukemia Lymphocytes

“…For example, DNA synthesis (6), adenosine deaminase (34), thymidine kinase (35), glucose-6-phosphate dehydrogenase, 6-phosphonogluconate dehydrogenase (36), 5'-nucleotidase (37,38), and ribosome function (39) are all deficient in CLL lymphocytes.…”

Ecto-5'-nucleotidase activities in lymphocytes and B lymphoblastoid cell lines from patients with congenital agammaglobulinemia.

“…Such low ecto-5'-NT activities, however, were not found consistently in the above-mentioned disease states (Lopes et al 1973;Silber et al 1975;Kanter et al 1979). In the present study ecto-5'-NT activities in both EBV-induced Ig-producing LCL and precursor B cell lines without Ig expression derived from CAG patients were not different from the enzyme activities in B LCL derived from healthy control subjects.…”