Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis during Chronic Obstructive Pulmonary Disease

Abstract

Running head: Lung cDC2 drive lymphoid neogenesis during COPD.

The basic immunology of asthma

“…The number of DCs is increased in the airways of patients with asthma. In the lung, most conventional CD1c-expressing DCs found in type 2-high patients express the high-affinity receptor FcεRI, suggesting a role for IgE and these DCs in Th2 airway inflammation, and suggesting they are highly related to cDC2s (Dutertre et al, 2019;Naessens et al, 2020). The difficulty of obtaining lung tissue samples from patients with ongoing asthma has made functional studies on DCs difficult.…”

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection

“…The TFs interferon regulatory factor 8 (IRF-8) and Batf3 drive the development of chemokine receptor XCR1-expressing cDC1s, which have the capacity to present and cross-present antigens to CD8 + T cells and are a copious source of interleukin-12 (IL-12) (Bagadia et al, 2019;Bajañ a et al, 2016;Durai et al, 2019;Edelson et al, 2010;Everts et al, 2016;Grajales-Reyes et al, 2015;Sichien et al, 2016). On the other hand, IRF4 drives the development and terminal differentiation of the CD11b + CD172a + -expressing cDC2 lineage, which is more specialized in polarizing CD4 + T helper (Th) cell responses and providing help to B cells (Bajañ a et al, 2012;Gao et al, 2013;Krishnaswamy et al, 2017;Kumamoto et al, 2013;Vander Lugt et al, 2014;Naessens et al, 2020;Satpathy et al, 2013;Schlitzer et al, 2013;Tussiwand et al, 2015;Williams et al, 2013).…”

Role of cholinergic anti-inflammatory pathway in protecting sepsis-induced acute lung injury through regulation of the dendritic cells

“…CD11c + CD11b + cDCs are the most abundant DCs in the lymphoid organs and are also found in the spleen, skin, and lung tissues. Previous studies have demonstrated that CD11c + CD11b + cDCs2 derived Th (T help cell) 17, Th2-immune responses in asthma, lung emphysema, and COPD [26][27][28]. CD11c + CD11b + cDCs2 also produce pro-in ammatory cytokines such as IL-6 and IL-23 [28,29].…”