volume 9, issue 12, P2504-2520 2017
DOI: 10.18632/aging.101334
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Abstract: We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10−8), including 8 previously identified for traits including survival, Alzheimer's and cardiovascular disease. Of these, 4 were also associated with longest 10% survival (mother's age ≥90 years, father's ≥87 years), with 2 additional associations including MC2R intronic variants (coding for the adrenocorticotropic h…

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