Human lncRNAs harbor conserved modules embedded in different sequence contexts
Francesco Ballesio,
Gerardo Pepe,
Gabriele Ausiello
et al.
Abstract:We analyzed the structure of human long non-coding RNA (lncRNAs) genes to investigate whether the non-coding transcriptome is organized in modular domains, as is the case for protein-coding genes. To this aim, we compared all known human lncRNA exons and identified 340 pairs of exons with high sequence and/or secondary structure similarity but embedded in a dissimilar sequence context. We grouped these pairs in 106 clusters based on their reciprocal similarities. These shared modules are highly conserved betwe… Show more
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