Human Leukocyte Antigens in Undifferentiated Spondyloarthritis

DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9

“…For example, it has been shown convincingly in the NOD model of diabetes that low affinity epitopes exist and are capable of transferring disease (Levisetti et al 2008). Various reports have observed that DR1201 influences the development of various forms of inflammatory arthritis (Cerna et al 1994; Liao et al 2007; Albert and Scholz 1998) and sarcoidosis (Grunewald 2010). Our results indicate that low affinity epitopes (including H1HA 187-203 and H1NP 109-125 ) exist even in the context of influenza responses.…”

“…DRB1*12:01 (DR1201) is a common allele in Asian populations (Gonzalez-Galarza et al 2011). It is also of immunologic interest, based on its study in the context of susceptibility to (Cerna et al 1994; Liao et al 2007; Albert and Scholz 1998) or protection from (Kapitány et al 2005) various forms of inflammatory arthritis, susceptibility to sarcoidosis (Grunewald 2010), and its ability to present tumor antigen CAMEL (Slager et al 2003) and hepatitis C antigen NS3 (Diepolder et al 1997). Historically, DR12 alleles have been classified together with DR11, as both belong to the older HLA-DR5 serotype group and share a high degree of amino acid sequence similarity (97.8% identity).…”

Analysis of risk factors causing health deficiency and its indicators in children with congenital heart diseases two years after radical surgery

“…Можно предположить, что иммунный фенотип определяет фенотипические проявления здоровья. Как для антигена HLA-DR5, так и для аллеля HLA-DRB1*12 выявлена положительная ассоциация с иммуновоспалительными заболеваниями, такими как недифференцированный спондилоартрит, ювенильный артрит, антифосфолипидный синдром [10,11], а одновременно с аллелем HLA-DRB1*11 установлена положительная ассоциация с аутоиммунным тиреодитом [12]. Вполне вероятно, что субклиническое иммунное воспаление у детей с HLA-DRB1*11 и HLA-DRB1*12 могло проявляться и в угнетении физического функционала.…”

A case of localized cervical bony ankylosis due to ulcerative colitis

“…Test results for the rheumatoid factor and anti-citrullinated protein antibody were negative. The test result for human leukocyte antigen (HLA)-B27 was negative, but the result for HLA-B60, which is associated with spondyloarthritis in the Asian population, was positive ( 2 , 3 ). Computed tomography of the cervical spine was performed, revealing bony ankylosis of both facet joints ( Figure 1 ).…”

“…In enteropathic spondyloarthritis, the prevalence of HLA-B27 is only between 53% and 75%; this is lower than that in ankylosing spondylitis ( 1 ). HLA-B60 is prevalent in patients with HLA-B27-negative ankylosing spondylitis and undifferentiated spondyloarthritis among the Asian population ( 2 , 3 ). HLA-B60 may be correlated with enteropathic spondyloarthritis.…”